Estradiol
- CAS No.
- 57-91-0
- Chemical Name:
- Estradiol
- Synonyms
- α-Estradiol;BETA-ESTRADIOL;17B-ESTRADIOL;ALPHA-ESTRADIOL;B-ESTRADIOL;17α-estradiol;Alfatradiol;17A-ESTRADIOL;EPIESTRADIOL;17ALPHA-ESTRADIOL
- CBNumber:
- CB7289534
- Molecular Formula:
- C18H24O2
- Molecular Weight:
- 272.39
- MDL Number:
- MFCD00064144
- MOL File:
- 57-91-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 176-180 °C(lit.) |
|---|---|
| alpha | D20 +53 to +56° (c = 0.9 in dioxane) |
| Boiling point | 355.44°C (rough estimate) |
| Density | 1.0708 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: 50 mg/mL, clear, colorless |
| form | powder |
| pka | 10.27±0.60(Predicted) |
| color | white with slight yellow |
| biological source | synthetic (organic) |
| Water Solubility | 3.9mg/L(25 ºC) |
| Merck | 14,3704 |
| InChI | 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 |
| InChIKey | VOXZDWNPVJITMN-SFFUCWETSA-N |
| SMILES | [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24 |
| CAS DataBase Reference | 57-91-0(CAS DataBase Reference) |
| FDA UNII | 3VQ38D63M7 |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
| Proposition 65 List | Estradiol 17B |
| EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H341-H351-H360F-H362-H410 |
| Precautionary statements | P201-P202-P260-P263-P273-P308+P313 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | T,Xn |
| Risk Statements | 45-48-40 |
| Safety Statements | 53-45-24/25-22 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | KG3750000 |
| F | 8-10 |
| HS Code | 29372390 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Aquatic Chronic 1 Carc. 2 Lact. Muta. 2 Repr. 1A |
Estradiol price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8750 | α-Estradiol powder, ≥98% (TLC) | 57-91-0 | 1g | $826 | 2026-04-30 | Buy |
| Sigma-Aldrich | 46542 | α-Estradiol VETRANAL | 57-91-0 | 100mg | $378 | 2026-04-30 | Buy |
| Cayman Chemical | 20776 | 17α-Estradiol ≥98% | 57-91-0 | 50mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 20776 | 17α-Estradiol ≥98% | 57-91-0 | 100mg | $84 | 2026-04-30 | Buy |
| Cayman Chemical | 20776 | 17α-Estradiol ≥98% | 57-91-0 | 500mg | $152 | 2026-04-30 | Buy |
Estradiol Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
target
Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor
storage
Room temperature
Purification Methods
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
Estradiol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Watson Biotechnology Co.,Ltd | 027-59207879 1972026995 18140587686 | sales@3600chem.com | China | 4180 | 55 |
| CHONGQING CHENCHENG PHARMACEUTICAL CO.，LTD. | 15310426561 | lf19823605252@163.com | China | 145 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
View Latest Price from Estradiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Estradiol
57-91-0
|
$10.00 | 1ASSAYS | 99% | 1 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-17 | 17-alpha Estradiol
57-91-0
|
1KG | USP, BP, GMP | 5,000KG | Hangzhou Hyper Chemicals Limited | ||
 |
2026-09-17 | 17α-Estradiol
57-91-0
|
1kg | 99%min | 50kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Estradiol
57-91-0
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- 17-alpha Estradiol
57-91-0
- USP, BP, GMP
- Hangzhou Hyper Chemicals Limited
-
- 17α-Estradiol
57-91-0
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
