AF12198
- CAS No.
- 185413-30-3
- Chemical Name:
- AF12198
- Synonyms
- AF12198;AF12198（TFA）;Ac-FEWTPGWYQ（Aze）YALPL-NH2;AF12198, human type I interleukin receptor antagonist;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2;L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
- CBNumber:
- CB5268870
- Molecular Formula:
- C96H123N19O22
- Molecular Weight:
- 1895.12
- MDL Number:
- MFCD02259571
- MOL File:
- 185413-30-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >179°C (dec.) |
|---|---|
| Density | 1.353±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Very Slightly) |
| form | solid |
| pka | 4.44±0.10(Predicted) |
| color | White to Off-White |
| Sequence | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2 |
AF12198 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 254553 | AF 12198 Asreported | 185413-30-3 | 1mg | $631 | 2026-06-03 | Buy |
| Biosynth | FA109195 | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2 | 185413-30-3 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FA109195 | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2 | 185413-30-3 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FA109195 | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2 | 185413-30-3 | 1mg | $900 | 2026-06-04 | Buy |
| Biosynth | FA109195 | Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2 | 185413-30-3 | 10mg | $1259.3 | 2026-06-04 | Buy |
AF12198 Chemical Properties, Uses, Production
Uses
AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.
in vivo
AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2].
| Animal Model: | Male Wistar rats[2] |
| Dosage: | 16mg/kg |
| Administration: | Intravenous infusion; 30min before LPS intravenous injection |
| Result: | Decreased pulmonary microvascular leakage in rats. |
IC 50
IL-6; IL-8; IL1R1: 8 nM (IC50)
storage
Store at -20°C
AF12198 Preparation Products And Raw materials
Raw materials
Preparation Products
AF12198 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
