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ChemicalBook >> CAS DataBase List >>2-Amino-5-chloro-4-fluoro-benzoic acid

2-Amino-5-chloro-4-fluoro-benzoic acid

2-Amino-5-chloro-4-fluoro-benzoic acid Structure
2-Amino-5-chloro-4-fluoro-benzoic acid structure
CAS No.
351367-77-6
Chemical Name:
2-Amino-5-chloro-4-fluoro-benzoic acid
Synonyms
5-Chloro-4-fluoroanthranilic Acid;2-Amino-5-chloro-4-fluoro-benzoic acid;BENZOIC ACID, 2-AMINO-5-CHLORO-4-FLUORO-
CBNumber:
CB52746158
Molecular Formula:
C7H5ClFNO2
Molecular Weight:
189.57
MDL Number:
MFCD09861352
MOL File:
351367-77-6.mol
MSDS File:
SDS
Last updated:2026-05-28 05:32:09
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2-Amino-5-chloro-4-fluoro-benzoic acid Properties

Melting point >250 °C (dec.)
Boiling point 350.3±42.0 °C(Predicted)
Density 1.574±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Sonicated), DMSO (Slightly)
form Solid
pka 4.51±0.10(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
HS Code  2922498590

2-Amino-5-chloro-4-fluoro-benzoic acid price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-A605598-50MG 2-Amino-5-chloro-4-fluoro-benzoic Acid 351367-77-6 50mg $109 2026-06-03 Buy
TRC TRC-A605598-25MG 2-Amino-5-chloro-4-fluoro-benzoic Acid 351367-77-6 25mg $59 2026-06-03 Buy
TRC TRC-A605598-250MG 2-Amino-5-chloro-4-fluoro-benzoic Acid 351367-77-6 250mg $358 2026-06-03 Buy
Biosynth BPA36777 2-Amino-5-chloro-4-fluorobenzoic acid 351367-77-6 0.5g $295 2026-06-04 Buy
Biosynth BPA36777 2-Amino-5-chloro-4-fluorobenzoic acid 351367-77-6 5g $1121 2026-06-04 Buy
Product number Packaging Price Buy
TRC-A605598-50MG 50mg $109 Buy
TRC-A605598-25MG 25mg $59 Buy
TRC-A605598-250MG 250mg $358 Buy
BPA36777 0.5g $295 Buy
BPA36777 5g $1121 Buy

2-Amino-5-chloro-4-fluoro-benzoic acid Chemical Properties, Uses, Production

Synthesis

2-Amino-4-fluorobenzoic acid

446-32-2

2-Amino-5-chloro-4-fluoro-benzoic acid

351367-77-6

Step-1: 2-Amino-4-fluorobenzoic acid (50 g, 322.6 mmol) was dissolved in 700 mL of N,N-dimethylformamide (DMF) followed by addition of N-chlorosuccinimide (41 g, 305.5 mmol) in batches. The reaction mixture was heated at 50 °C with stirring for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to precipitate a solid. The solid was collected by filtration, dissolved in ethyl acetate (EtOAc) and washed with saturated sodium chloride solution (300 mL). The aqueous layer was back-extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the product 2-amino-5-chloro-4-fluorobenzoic acid (42 g, 69% yield) as a brown solid.

References

[1] Patent: WO2016/171755, 2016, A1. Location in patent: Paragraph 0101
[2] Patent: US2016/311818, 2016, A1. Location in patent: Paragraph 0465; 0466
[3] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 122
[4] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 251

2-Amino-5-chloro-4-fluoro-benzoic acid Preparation Products And Raw materials

Raw materials

2-Amino-4-fluorobenzoic acid N,N-Dimethylformamide N-Chlorosuccinimide

Preparation Products

2-Amino-5-chloro-4-fluoro-benzoic acid Suppliers

Global Suppliers ( 35)
Supplier Tel Email Country ProdList Advantage
Xinyanhe Pharmatech Co.,Ltd 0519-85252752 15366845260 taihuaren@vip.163.com China 1031 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3700 58
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
BePharm Ltd 400-685-9117 market@bepharm.com China 15081 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Shanghai Anmike Chemical Co. Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 9988 55
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Supplier Advantage
Xinyanhe Pharmatech Co.,Ltd 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
JW & Y Pharmlab Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
BePharm Ltd 60
Shanghai SuperLan Chemcial Technique Centre 58
Shanghai Anmike Chemical Co. Ltd. 55
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58

2-Amino-5-chloro-4-fluoro-benzoic acid Spectrum

2-Amino-5-chloro-4-fluoro-benzoic acid(351367-77-6)1HNMR

351367-77-6 (2-Amino-5-chloro-4-fluoro-benzoic acid) Related Search:

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2-Amino-5-chloro-4-fluoro-benzonitrile

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2-Amino-5-chloro-4-fluoro-benzoic acid BENZOIC ACID, 2-AMINO-5-CHLORO-4-FLUORO- 5-Chloro-4-fluoroanthranilic Acid 351367-77-6