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| | 2-Amino-5-chloro-4-fluoro-benzoic acid Basic information |
| | 2-Amino-5-chloro-4-fluoro-benzoic acid Chemical Properties |
| Melting point | >250 °C (dec.) | | Boiling point | 350.3±42.0 °C(Predicted) | | density | 1.574±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly) | | form | Solid | | pka | 4.51±0.10(Predicted) | | color | White to Off-White |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2922498590 |
| | 2-Amino-5-chloro-4-fluoro-benzoic acid Usage And Synthesis |
| Synthesis | Step-1: 2-Amino-4-fluorobenzoic acid (50 g, 322.6 mmol) was dissolved in 700 mL of N,N-dimethylformamide (DMF) followed by addition of N-chlorosuccinimide (41 g, 305.5 mmol) in batches. The reaction mixture was heated at 50 °C with stirring for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to precipitate a solid. The solid was collected by filtration, dissolved in ethyl acetate (EtOAc) and washed with saturated sodium chloride solution (300 mL). The aqueous layer was back-extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the product 2-amino-5-chloro-4-fluorobenzoic acid (42 g, 69% yield) as a brown solid. | | References | [1] Patent: WO2016/171755, 2016, A1. Location in patent: Paragraph 0101
[2] Patent: US2016/311818, 2016, A1. Location in patent: Paragraph 0465; 0466
[3] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 122
[4] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 251 |
| | 2-Amino-5-chloro-4-fluoro-benzoic acid Preparation Products And Raw materials |
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