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4-Amino-5-imidazolecarboxamide hydrochloride

4-Amino-5-imidazolecarboxamide hydrochloride structure

CAS No.: 72-40-2

Chemical Name:: 4-Amino-5-imidazolecarboxamide hydrochloride

Synonyms: Dacarbazine Related CoMpound A;AICA;AICA HCL;AIC .cntdot. HCl;AICA HYDROCHLORIDE;TIMTEC-BB SBB003938;5-Amino-1H-imidazoL;LABOTEST-BB LT00440910;e-4-carboxamide hydrochL;Temozolomide intermediate

CBNumber:: CB5300628

Molecular Formula:: C4H7ClN4O

Molecular Weight:: 162.58

MDL Number:: MFCD00012704

MOL File:: 72-40-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-12 21:25:05

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4-Amino-5-imidazolecarboxamide hydrochloride Properties

Melting point	250-252 °C (dec.)(lit.)
storage temp.	2-8°C
solubility	water: soluble50mg/mL, clear, light yellow
form	Crystals or Crystalline Powder
color	White
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	3701645
Stability	Hygroscopic
InChI	InChI=1S/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H
InChIKey	MXCUYSMIELHIQL-UHFFFAOYSA-N
SMILES	C1(N=CNC=1N)C(=O)N.Cl
CAS DataBase Reference	72-40-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	220691X0M3
NIST Chemistry Reference	Imidazole-4(5)-carboxamide, 5-(4)-amino-, hydrochloride(72-40-2)
EPA Substance Registry System	1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride (72-40-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Xi,Xn

Risk Statements

20/21/22-36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

NI3911000

Hazard Note

Irritant

TSCA

TSCA listed

HS Code

29332990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

4-Amino-5-imidazolecarboxamide hydrochloride price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	164968	5-Amino-4-imidazolecarboxamide hydrochloride 98%	72-40-2	5g	$25.9	2026-04-30	Buy
Sigma-Aldrich	PHR2304	Dacarbazine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	72-40-2	100MG	$593	2026-04-30	Buy
Sigma-Aldrich	1162320	Dacarbazine Related Compound A United States Pharmacopeia (USP) Reference Standard	72-40-2	50mg	$1290	2026-04-30	Buy
TCI Chemical	A1175	5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride >98.0%(HPLC)(T)	72-40-2	5g	$47	2026-04-30	Buy
TCI Chemical	A1175	5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride >98.0%(HPLC)(T)	72-40-2	25g	$173	2026-04-30	Buy

Product number	Packaging	Price	Buy
164968	5g	$25.9	Buy
PHR2304	100MG	$593	Buy
1162320	50mg	$1290	Buy
A1175	5g	$47	Buy
A1175	25g	$173	Buy

4-Amino-5-imidazolecarboxamide hydrochloride Chemical Properties, Uses, Production

Chemical Properties

very slightly beige fine powder

Uses

5-Amino-4-imidazolecarboxamide hydrochloride was used in the synthesis of heterocyclic compounds such as guanine, purines and pyrimidines.

General Description

Corrosion inhibition and adsorption characteristics of 5-amino-4-imidazolecarboxamide hydrochloride on aluminum in 1M HCl has been investigated.

Synthesis

47 g of sodium nitrite was dissolved in 1.2 liters of water; The solution was cooled to 0° C. 100 g of 5-aminoimidazole-4 carboxamide was dissolved in a solution of hydrochloric acid (80 ml of 36% HCL in 720 ml water) with stirring. The resultant 5-aminoimidazole-4 carboxamide hydrochloride solution was added slowly, drop-wise, over 20-30 minutes at 0-5° C. After the addition was completed, the reaction mixture was stirred for 10 minutes and filtered. The solid obtained was suspended in 400 ml DM water and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. The obtained solid was suspended in 500 ml of THF and stirred for 15 minutes. The suspension was filtered and suction-dried for 15 minutes. Finally, the solid was dried at 45° C. to afford 4-Amino-5-imidazolecarboxamide hydrochloride.

Purification Methods

Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.]

4-Amino-5-imidazolecarboxamide hydrochloride synthesis

Synthesis of 4-Amino-5-imidazolecarboxamide hydrochloride from 5-Amino-4-imidazolecarboxamide

4-Amino-5-imidazolecarboxamide hydrochloride Preparation Products And Raw materials

Raw materials

carbanilic acid Acetamide

Preparation Products

5-(Amino-1-(N-methyl Carbamoyl) Ethyl 4-amino-5-imidazolecarboxylate

4-Amino-5-imidazolecarboxamide hydrochloride Suppliers

Global Suppliers ( 463)

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.	0551-65523315 17705606359	errol@homesunshinepharma.com	China	64	58
Hunan Kaimir Biotechnology Co., Ltd.	0731-+86-0731-89714511 +86-18602659358	sales@chemapi.com.cn	China	35	58
Beijing Whale Technology Corporation Ltd.	010-83694934 13671295325	sales@whalecorporation.com	China	107	58
Beijing Mesochem Technology Co., Ltd.	010-57862036 18811083386;	msales@mesochem.com	China	209	58
Jinan Hongda Trading Co., Ltd.	18753193522	Sales@hkdchem.com	China	63	58
Jinan Hongkangda Chemical Co., Ltd	0531-88901705 18753193522	810353473@qq.com	China	156	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.	58
Hunan Kaimir Biotechnology Co., Ltd.	58
Beijing Whale Technology Corporation Ltd.	58
Beijing Mesochem Technology Co., Ltd.	58
Jinan Hongda Trading Co., Ltd.	58
Jinan Hongkangda Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84

View Latest Price from 4-Amino-5-imidazolecarboxamide hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	5-Amino-4-imidazolecarboxamide 72-40-2		1KG	99%	1t	Shaanxi Dideu New Materials Co. Ltd
2026-06-30	4-Amino-5-imidazolecarboxamide hydrochloride 72-40-2		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-05-28	4-Amino-5-Imidazolecarboxamide Hydrochloride 72-40-2	$9.00	1KG	99.8%	100tons	Hebei Chuanghai Biotechnology Co,.LTD

5-Amino-4-imidazolecarboxamide
72-40-2
99%
Shaanxi Dideu New Materials Co. Ltd

4-Amino-5-imidazolecarboxamide hydrochloride
72-40-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Amino-5-Imidazolecarboxamide Hydrochloride
72-40-2
$9.00
99.8%
Hebei Chuanghai Biotechnology Co,.LTD

4-Amino-5-imidazolecarboxamide hydrochloride Spectrum

4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)MS 4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)¹HNMR 4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)¹³CNMR 4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)IR1 4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)IR2 4-Amino-5-imidazolecarboxamide hydrochloride(72-40-2)Raman

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1of4

5-amino-4-imidazolecarboxamide hydrochloride (intermediate of dacarbazine) 5-Amino-1H-imidazole-4-carboxamide hydrochloride 98% 5-amino-1H-imidazole-4-carboxamide HCl 4-Amino-5-(aminocarbonyl)imidazole Hydrochloride 4-AMINO-5-IMIDAZOLECARBOXAMIDE HCL, (AICA) 98+% 4-AMINO-5-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 99% 4-Amino-5-imidazolecarboxamide hydrochloride ,99% 4-Amino-5-imidazolecarboxamide hydrochloride,98% Dacarbazine Related Compound A (50 mg) (5-aminoimidazole-4-carboxamide hydrochloride) 4-amino-1H-imidazole-5-carboxamide HCL 5-AMino-3H-iMidazole-4-carboxylic acid aMide hydrochloride 5-AMONO-4-IMIDAZOLE CARBOXAMIDE HYDROCHLORIDE AMino - 4-5 - iMidazole carboxaMide hydrochloride 5(4)-AMINO-4(5)-(AMINOCARBONYL)IMIDAZOLE HYDROCHLORIDE 5(4)-AMINO-4(5)-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 5(4)-AMINOIMIDAZOLE-4(5)-CARBOXAMIDE HYDROCHLORIDE 5-AMINO-4-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 5-AMINOIMIDAZOLE-4-CARBOXAMIDE HYDROCHLORIDE 5-AMINO-3H-IMIDAZOLE-4-CARBOXYLIC ACID AMIDE HCL 4-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE HYDROCHLORIDE 4-AMINO-5-IMIDAZOLECARBOXAMIDE HCL 4-AMINO-5-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 4-AMINO-5-CARBOXAMIDO IMIDAZOLE HCL 4(5)-AMINO-5(4)-IMIDAZOLECARBOXAMIDE HYDROCHLORIDE 4-AMINOIMIDAZOLE-5-CARBOXAMIDE HYDROCHLORIDE 4-Aminoimidazole-5-carboxamidehydrochloride,98% 5-Amino-4-imidazolecarboxamide hydrochloride 98% Imidazole-4-carboxamide, 5-amino-, monohydrochloride AICA HCL AICA HYDROCHLORIDE N-(4-Amino-1H-imidazol-5-yl)formamidehydrochloride TIMTEC-BB SBB003938 4-Amino-5-carbamoylimidazole salt of hydrochloric acid 5-aminoimidazole-4-carboxamide HCl 5-amino-1H-imidazole-4-carboxamide monohydrochloride 4-Amino-5-imidazolecarboxamide hydrochloride;AICA 5-Amino-1H-imidazole-4-carboxamide hydrochloride 5-Aminoindazole-4-Carboxyamide Hydrochloride 5-Amino-4-imidazolecarboxamide hydrochloride, 98 4(5)-Amino-5(4)-Imidazolecarboxamide HCl LABOTEST-BB LT00440910 Temozolomide intermediate 5-amino-1h-imidazole-4-carboxamidmonohydrochloride 5-Aminoimidazol-4-carboxamide, hydrochloride 5-Imidazolecarboxamide, 4-amino-, hydrochloride AIC .cntdot. HCl 1H-Imidazole-4-carboxamide, 5-amino-, monohydrochloride 4-Amino-5-carboxamido imidazole hydrochloride 4-amino-5-imidazolecarboxamidhydrochloride 4-Aminoimidazole-5-carboxamide hydrochoride Dacarbazine EP Impurity B(USP RC A) imidazolecarboxamide hydrochloride 5(4)-Amino-4(5)-(aminocarbonyl)imidazole Hydrochloride > Dacarbazine EP Impurity B 5-Amino-1H-imidazoL e-4-carboxamide hydrochL Dacarbazine EP Impurity B HCl 4-amino-5-imidazolium formamide hydrochloride