Kushenol K
- CAS No.
- 101236-49-1
- Chemical Name:
- Kushenol K
- Synonyms
- Kushenol K;product/154906;(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-
- CBNumber:
- CB53034759
- Molecular Formula:
- C26H32O8
- Molecular Weight:
- 472.53
- MDL Number:
- MFCD31579630
- MOL File:
- 101236-49-1.mol
| Product description | Number | Pack Size | Price |
| KushenolK ≥98% | CFN92534 | 5mg | $498 |
| KushenolK(NewProduct) 98%(HPLC) | JR8-N1216 | 5mg | $518 |
| KushenolK(NewProduct) 98%(HPLC) | JR8-N1216 | 10mg | $968 |
| KushenolK(NewProduct) 98%(HPLC) | JR8-N1216 | 20mg | $1980 |
| More product size | |||
Kushenol K price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Arctom | CFN92534 | KushenolK ≥98% | 101236-49-1 | 5mg | $498 | 2021-12-16 | Buy |
| JR MediChem | JR8-N1216 | KushenolK(NewProduct) 98%(HPLC) | 101236-49-1 | 5mg | $518 | 2021-12-16 | Buy |
| JR MediChem | JR8-N1216 | KushenolK(NewProduct) 98%(HPLC) | 101236-49-1 | 10mg | $968 | 2021-12-16 | Buy |
| JR MediChem | JR8-N1216 | KushenolK(NewProduct) 98%(HPLC) | 101236-49-1 | 20mg | $1980 | 2021-12-16 | Buy |
Kushenol K Chemical Properties,Uses,Production
Uses
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
Biological Activity
Kushenol K, a flavonoid antioxidant from Sophora flavescens. It can inhibit the activity of SGLT1 and SGLT2 and used as an inhibitor of CYP3A4 with a Ki value of 1.35 μM.
in vivo
When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC 50 values of 1.62 μM.
At a concentration of 50 μM, the The inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.
target
PDE
IC 50
CYP3A4: 1.35 μM (Ki); CYP3; SGLT1; SGLT2; HSV-2: 147 μM (EC50)
References
[1] Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. DOI:10.1016/j.toxlet.2018.05.008
[2] E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4. DOI:10.1021/np980103j
[3] Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DOI:10.1016/j.bmc.2007.03.011
Kushenol K Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15178 | 58 |
| Shanghai Aspire Biological Technology Co., Ltd. | 021-61317773 | sales@aspirebio.com | China | 2880 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8144 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
