| Identification | Back Directory | [Name]
Kushenol K | [CAS]
101236-49-1 | [Synonyms]
Kushenol K
product/154906
(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)- | [Molecular Formula]
C26H32O8 | [MDL Number]
MFCD31579630 | [MOL File]
101236-49-1.mol | [Molecular Weight]
472.53 |
| Hazard Information | Back Directory | [Uses]
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3]. | [Biological Activity]
Kushenol K, a flavonoid antioxidant from Sophora flavescens. It can inhibit the activity of SGLT1 and SGLT2 and used as an inhibitor of CYP3A4 with a Ki value of 1.35 μM. | [in vivo]
When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC 50 values of 1.62 μM.
At a concentration of 50 μM, the The inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%. | [target]
PDE | [IC 50]
CYP3A4: 1.35 μM (Ki); CYP3; SGLT1; SGLT2; HSV-2: 147 μM (EC50) | [References]
[1] Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. DOI:10.1016/j.toxlet.2018.05.008
[2] E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4. DOI:10.1021/np980103j
[3] Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DOI:10.1016/j.bmc.2007.03.011 |
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