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6-BROMO-2-METHYLBENZODOXAZOLE

CAS No.
151230-42-1
Chemical Name:
6-BROMO-2-METHYLBENZODOXAZOLE
Synonyms
6-BROMO-2-METHYLBENZOXAZOLE;6-BROMO-2-METHYLBENZODOXAZOLE;6-Bromo-2-methyl-benzooxazole;Benzoxazole, 6-bromo-2-methyl-;6-BroMo-2-Methyl-1,3-benzoxazole
CBNumber:
CB5309757
Molecular Formula:
C8H6BrNO
Molecular Weight:
212.04
MDL Number:
MFCD06659628
MOL File:
151230-42-1.mol
MSDS File:
SDS
Last updated:2026-05-28 03:21:16
Product description Number Pack Size Price
6-Bromo-2-methylbenzoxazole 97% 761729 500mg $110
6-Bromo-2-methylbenzo[d]oxazole 119806 1.00g $216
6-Bromo-2-methylbenzo[d]oxazole 119806 5.00g $864
6-Bromo-2-methylbenzo[d]oxazole ≥97% AA00386N 250mg $10
6-Bromo-2-methylbenzo[d]oxazole ≥97% AA00386N 500mg $18

6-BROMO-2-METHYLBENZODOXAZOLE Properties

Melting point 44-49°C
Boiling point 264.8±13.0 °C(Predicted)
Density 1.606±0.06 g/cm3(Predicted)
Flash point >110℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
form solid
pka -0.09±0.30(Predicted)
Appearance Yellow to orange Solid
InChI 1S/C8H6BrNO/c1-5-10-7-3-2-6(9)4-8(7)11-5/h2-4H,1H3
InChIKey ZCGXHOLCXPKKBO-UHFFFAOYSA-N
SMILES Cc1nc2ccc(Br)cc2o1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

6-BROMO-2-METHYLBENZODOXAZOLE price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 761729 6-Bromo-2-methylbenzoxazole 97% 151230-42-1 500mg $110 2023-06-20 Buy
Matrix Scientific 119806 6-Bromo-2-methylbenzo[d]oxazole 151230-42-1 1.00g $216 2026-05-18 Buy
Matrix Scientific 119806 6-Bromo-2-methylbenzo[d]oxazole 151230-42-1 5.00g $864 2026-05-18 Buy
aablocks AA00386N 6-Bromo-2-methylbenzo[d]oxazole ≥97% 151230-42-1 250mg $10 2026-05-28 Buy
aablocks AA00386N 6-Bromo-2-methylbenzo[d]oxazole ≥97% 151230-42-1 500mg $18 2026-05-28 Buy
Product number Packaging Price Buy
761729 500mg $110 Buy
119806 1.00g $216 Buy
119806 5.00g $864 Buy
AA00386N 250mg $10 Buy
AA00386N 500mg $18 Buy

6-BROMO-2-METHYLBENZODOXAZOLE Chemical Properties,Uses,Production

Synthesis

2-AMINO-5-BROMOPHENOL

38191-34-3

Triethyl orthoacetate

78-39-7

6-BROMO-2-METHYLBENZODOXAZOLE

151230-42-1

Using 2-amino-5-bromophenol (561 mg, 3.00 mmol) and triethyl orthoacetate (656 μL, 3.6 mmol) as the raw material, 1,3-dibromo-5,5-dimethylglycolonide (17.2 mg, 0.060 mmol) was added as a catalyst. The reaction mixture was stirred at room temperature for 10 min. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (50 mL × 2). The organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane (1:4, v/v) as eluent to afford 6-bromo-2-methylbenzoxazole (560 mg, 88.5% yield).

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[2] Patent: JP2016/79108, 2016, A. Location in patent: Paragraph 0063
[3] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 128
[4] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 113

6-BROMO-2-METHYLBENZODOXAZOLE Preparation Products And Raw materials

6-BROMO-2-METHYLBENZODOXAZOLE Suppliers

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6-BROMO-2-METHYLBENZODOXAZOLE Spectrum

6-BROMO-2-METHYLBENZODOXAZOLE 6-BROMO-2-METHYLBENZOXAZOLE 6-BroMo-2-Methyl-1,3-benzoxazole 6-Bromo-2-methyl-benzooxazole Benzoxazole, 6-bromo-2-methyl- 151230-42-1