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Triethyl orthoacetate

Triethyl orthoacetate structure

CAS No.: 78-39-7

Chemical Name:: Triethyl orthoacetate

Synonyms: TEOA;1,1,1-TRIETHOXYETHANE;Ethane, 1,1,1-triethoxy-;ETHYL ORTHOACETATE;Triethylorthoacetat;TRIETHYL-O-ACETATE;triethyl ester orthoacetic acid;ETHYL O-ACETATE;Triethyl proacetate;TRIETHYL ORTHACETATE

CBNumber:: CB7702576

Molecular Formula:: C8H18O3

Molecular Weight:: 162.23

MDL Number:: MFCD00009223

MOL File:: 78-39-7.mol

MSDS File:: SDS

Last updated:2026-05-28 02:46:22

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Triethyl orthoacetate Properties

Boiling point	142 °C (lit.)
Density	0.885 g/mL at 25 °C (lit.)
vapor pressure	3.4 hPa (20 °C)
RTECS	KJ4075000
refractive index	n20/D 1.396(lit.)
Flash point	97 °F
storage temp.	Store below +30°C.
solubility	soluble in Chloroform, Ethyl Acetate
form	Liquid
color	Clear colorless to slightly yellow
explosive limit	0.9-7.0%(V)
Water Solubility	SLIGHTLY SOLUBLE
Sensitive	Moisture Sensitive
BRN	506201
InChI	1S/C8H18O3/c1-5-9-8(4,10-6-2)11-7-3/h5-7H2,1-4H3
InChIKey	NDQXKKFRNOPRDW-UHFFFAOYSA-N
SMILES	CCOC(C)(OCC)OCC
LogP	2.6 at 20℃
CAS DataBase Reference	78-39-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	48352MHC78
NIST Chemistry Reference	Ethane, 1,1,1-triethoxy-(78-39-7)
EPA Substance Registry System	Ethane, 1,1,1-triethoxy- (78-39-7)
UNSPSC Code	12352112
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

10-36/38

Safety Statements

26-37/39-16

RIDADR

UN 3272 3/PG 3

WGK Germany

Autoignition Temperature

455 °C

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29159080

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	3
2		2

Triethyl orthoacetate price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.20934	Triethyl orthoacetate for synthesis	78-39-7	50mL	$31.3	2026-04-30	Buy
Sigma-Aldrich	8.20934	Triethyl orthoacetate for synthesis	78-39-7	100mL	$39.3	2026-04-30	Buy
Sigma-Aldrich	8.20934	Triethyl orthoacetate for synthesis	78-39-7	500mL	$80.1	2026-04-30	Buy
Sigma-Aldrich	75580	Triethyl orthoacetate purum, ≥98.0% (GC)	78-39-7	100ml	$50.1	2026-04-30	Buy
Sigma-Aldrich	75580	Triethyl orthoacetate purum, ≥98.0% (GC)	78-39-7	500ml	$137	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.20934	50mL	$31.3	Buy
8.20934	100mL	$39.3	Buy
8.20934	500mL	$80.1	Buy
75580	100ml	$50.1	Buy
75580	500ml	$137	Buy

Triethyl orthoacetate Chemical Properties, Uses, Production

Description

Triethyl orthoacetate is the ethyl orthoester of acetic acid. It is an oily liquid with a pungent odor. Triethyl orthoacetate is used as a water scavenger and as intermediate for synthesis of pharmaceuticals. It is used in organic synthesis for the introduction of the acetate group to an alcohol and in the Johnson-Claisen rearrangement.

Reference

J. S. Lindsey, I. C. Schreiman, H. C. Hsu, P. C. Kearney, A. M. Marguerettaz, Rothemund and Adler-Longo reactions revisited: synthesis of tetraphenylporphyrins under equilibrium conditions, The Journal of Organic Chemistry, 1987, vol. 52, pp. 827-836
R. C. Capozza, Polymeric orthoesters housing beneficial drug for controlled release therefrom, Patent US4066747A

Chemical Properties

clear colourless liquid

Uses

Intermediate.

Uses

Triethyl orthoacetate is used as pharmaceutical and water scavenger. It is also used in organic synthesis to introduce the acetate group into an alcohol. It is involved in the Johnson-Claisen rearrangement.

Hazard

Moderate fire risk.

Flammability and Explosibility

Flammable

Triethyl orthoacetate synthesis

Synthesis of Triethyl orthoacetate from Diethyl ether and Ethyl acetate

Triethyl orthoacetate Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde Acetamide Thymol Blue Sodium chloride Indicator

Trimethyl orthoacetate Sodium ethylate solution,in ethyl alcohol Ammonium chloride

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Preparation Products

ethyl 3,3-dimethylpent-4-en-1-oate 1,2-Phenylenediacetic acid ethyl 4,6,6-trichloro-3,3-dimethyl-hex-5-enoate Permethrin 4-Amino-6-methylpyrimidine-5-carbonitrile ,97%

BROTIZOLAM Diethyl acetamidomalonate Tazarotene 4,4,4-Trichloroacetoacetic acid ethyl ester 2-ethylquinazolin-4-ol

6-Bromo-2-methyloxazolo[4,5-b]pyridine 2-[3-(Dimethylamino)-1-methoxy-2-propenylidene]malononitrile 1,3,5(10), 9(11)-Estratetraen-3-ol-17-one Ethyl trans-4-decenoate 4-Octenoic acid, 6-methyl-, ethyl ester, (E)- (9CI)

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Triethyl orthoacetate Suppliers

Global Suppliers ( 451)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Xinhua Pharmceutical Co.,LTD	0533- 2196801	yaojianyong@xhzy.com	China	70	60
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Weifang Mingran Chemical Co., Ltd.	QQ117761326 QQ2829453795 15063661899;	mingranchem@163.com	China	493	58
Weifang Runzhong Fine Chemical Co., LTD	18653686003	sq@runzhongchem.com	China	81	58
Jiangsu Runfeng Synthetic Technology Co., Ltd.	0513-66017678 18551497631	507167383@qq.com	China	4975	58
Shandong Xiangjingbang Energy Co., Ltd.	15550001115 15550001115	qihang163361@163.com	China	2094	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Shandong Xinhua Pharmceutical Co.,LTD	60
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Weifang Mingran Chemical Co., Ltd.	58
Weifang Runzhong Fine Chemical Co., LTD	58
Jiangsu Runfeng Synthetic Technology Co., Ltd.	58
Shandong Xiangjingbang Energy Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

Triethyl Orthoacetate: Applications in Organic Synthesis and Esterification
Triethyl orthoacetate aids N-acetylation/esterification of amino acids and selective esterification of phosphonic acids in syn....
Aug 6,2025

View Latest Price from Triethyl orthoacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	Triethyl orthoacetate 78-39-7	$1.20-31.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-09-01	Triethyl Orthoacetate 78-39-7		1kg	99%	10000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2026-03-20	Triethyl orthoacetate 78-39-7	$10.00	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd

Triethyl orthoacetate
78-39-7
$1.20-31.00
99%
Henan Fengda Chemical Co., Ltd

Triethyl Orthoacetate
78-39-7
$0.00
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Triethyl orthoacetate
78-39-7
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Triethyl orthoacetate Spectrum

Triethyl orthoacetate(78-39-7)MS Triethyl orthoacetate(78-39-7)¹HNMR Triethyl orthoacetate(78-39-7)¹³CNMR Triethyl orthoacetate(78-39-7)IR1 Triethyl orthoacetate(78-39-7)IR2 Triethyl orthoacetate(78-39-7)Raman

78-39-7 (Triethyl orthoacetate) Related Search:

Ethyl acetate Triethyl phosphate Triethyl methanetricarboxylate Ethyl trifluoroacetate acetic acid, triethoxy-, ethyl ester

Ethyl cyanoacetate Ethyl chloroacetate Triethyl phosphite Ethyl phenylacetate Triethyl phosphonoacetate

Tetramethoxymethane Dimethyl itaconate Diethyl phosphite Trimethyl orthobutyrate Tripropyl orthoformate

Homosalate TRILAURIN PROTOGRACILLIN(P)

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Ethyl Orthoacetate 1,1,1-Triethoxyethane Orthoacetic Acid Triethyl Ester The originalacetic acidethyl ester three The original three ethyl acetate 1,1′,1′′-(Ethylidynetris[oxy])-tris(ethane) Triethyl orthoacetate purum, >=98.0% (GC) Triethyl orthoacetate(TEOA) 1,1,1-triethoxy-ethan LABOTEST-BB LT00067780 TRIETHYL ORTHACETATE TRIETHYL ORTHOACETATE TRIETHYL-ORTHO ACETOACETATE TRIETHYL-O-ACETATE Triethylorthoacetate,98% triethyl ester orthoacetic acid Triethyl Orthoacetate-1,2-13C2 Ethane, 1,1,1-triethoxy- Triethyl orthoacetate, 97% 100ML Triethyl orthoacetate, 97% 2.5LT Triethyl orthoacetate, 97% 500ML ORTHOACETIC ACID TRIETHYL ESTER TRIETHYL ORTHOACETATETRIETHYL ORTHOACETATE ETHYL O-ACETATE Methylorthoformic acid triethyl ester Orthoacetic acid triethyl Triethyl orthoacetate,99% Triethyl orthoacetate,97% Triethyl orthoacetate ,98.5% TriethylOrthoacetate> Triethyl proacetate Valproic Acid Impurity 97 Triethyl orthoacetate, 95% 1,1,1-TRIETHOXYETHANE ETHYL ORTHOACETATE TEOA Triethylorthoacetat 78-39-7 CH3COC2H53 CH3COCH2CH33 Orthoesters Building Blocks Oxygen Compounds Organic Building Blocks Acetals/Ketals/Ortho Esters Intermediates of Dyes and Pigments Orthoesters Acetals/Ketals/Ortho Esters Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds

Triethyl orthoacetate

Triethyl orthoacetate Properties

SAFETY

Risk and Safety Statements

Triethyl orthoacetate price More Price(44)

Triethyl orthoacetate Chemical Properties, Uses, Production

Description

Reference

Chemical Properties

Uses

Uses

Hazard

Flammability and Explosibility

Triethyl orthoacetate synthesis

Triethyl orthoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Triethyl orthoacetate Suppliers

Related articles

View Latest Price from Triethyl orthoacetate manufacturers

Triethyl orthoacetate Spectrum

78-39-7 (Triethyl orthoacetate) Related Search: