Choline glycerophosphate
- CAS No.
- 28319-77-9
- Chemical Name:
- Choline glycerophosphate
- Synonyms
- Alpha GPC;GPC;CHOLINE ALFOSCERATE;glycerophosphocholine;SN-GLYCERO-3-PHOSPHOCHOLINE;GLYCEROPHOSPHORYLCHOLINE;L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE;Alpha GPC powder;L-α-glycerylphosphorylcholine;L-A-glycerophosphorylcholine
- CBNumber:
- CB5309777
- Molecular Formula:
- C8H20NO6P
- Molecular Weight:
- 257.22
- MDL Number:
- MFCD00063544
- MOL File:
- 28319-77-9.mol
| Melting point | 142.5-143° |
|---|---|
| alpha | D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8) |
| Boiling point | 480℃[at 101 325 Pa] |
| vapor pressure | 0Pa at 25℃ |
| Flash point | 11 °C |
| storage temp. | -20°C |
| solubility | DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly) |
| form | solid |
| color | White to Off-White |
| biological source | soybean |
| Water Solubility | 1000g/L at 25℃ |
| Stability | Very Hygroscopic |
| InChI | InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3 |
| InChIKey | SUHOQUVVVLNYQR-SBYBRXNCNA-N |
| SMILES | P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO |&1:12,r| |
| LogP | -5.15 at 25℃ |
| CAS DataBase Reference | 28319-77-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 60M22SGW66 |
| ATC code | N07AX02 |
| UNSPSC Code | 12352204 |
| NACRES | NA.83 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H412 |
| Precautionary statements | P261-P273-P305+P351+P338 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45-24/25 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 2 |
| RTECS | KH2775000 |
| HS Code | 29239000 |
Choline glycerophosphate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G5291 | 10 mg | $69.1 | 2025-07-31 | Buy | ||
| Sigma-Aldrich | G5291 | 50 mg | $200 | 2025-07-31 | Buy | ||
| Sigma-Aldrich | G5291 | 100 mg | $328 | 2025-07-31 | Buy | ||
| Sigma-Aldrich | G5291 | L-α-Glycerophosphorylcholine from soybean, ≥98%, powder | 28319-77-9 | 50mg | $184 | 2024-03-01 | Buy |
| Sigma-Aldrich | G5291 | L-α-Glycerophosphorylcholine from soybean, ≥98%, powder | 28319-77-9 | 100mg | $318 | 2024-03-01 | Buy |
Choline glycerophosphate Chemical Properties,Uses,Production
Description
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
Chemical Properties
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
Originator
Sandoz; Italfarmaco (Italy)
Uses
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
Uses
L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.
Definition
ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
brand name
Delecit
General Description
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Increases inositol phosphate formation.
Synthesis
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).
References
[1] Patent: KR2015/94159, 2015, A. Location in patent: Paragraph 0083-0085
Choline glycerophosphate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TIANJIN KANGCHAO BIO-PHARMACEUTICAL TECH CO.,LTD | +8613212281255 | kangchao1208@126.com | China | 1 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5949 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 922 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | 1713330907@QQ.com | China | 2639 | 58 |
| Changzhou Mascot Import & Export Co., Ltd | +86-0519-85010339 +86-13584504415 | info@mascot-ie.com | China | 396 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 453 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Handan City Zechi trading Co., LTD | +8619003396151 | 13165586887@163.com | China | 570 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046; | sales01@watsonbiotech.cn | China | 5757 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3091 | 58 |
Related articles
- Clinical research into Choline glycerophosphate
- Choline glycerophosphate (GPC) is a deacylated phosphatidylcholine derivative and is widely used as a dietary supplement.
- Mar 14，2025
View Lastest Price from Choline glycerophosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-18 | Alpha-GPC Chonile Alfoscerate
28319-77-9
|
US $20.00 / kg | 1kg | 99.9% | 10000 | Hebei Miaoyin Technology Co.,Ltd | |
 |
2025-08-17 | Choline glycerophosphate
28319-77-9
|
US $1.00 / g | 1g | 99% | 1000kg | RongNa Biotechnology Co.,Ltd | |
 |
2025-08-15 | Choline glycerophosphate
28319-77-9
|
US $0.00-0.00 / kg | 1kg | 99%min HPLC | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Alpha-GPC Chonile Alfoscerate
28319-77-9
- US $20.00 / kg
- 99.9%
- Hebei Miaoyin Technology Co.,Ltd
-
- Choline glycerophosphate
28319-77-9
- US $1.00 / g
- 99%
- RongNa Biotechnology Co.,Ltd
-
- Choline glycerophosphate
28319-77-9
- US $0.00-0.00 / kg
- 99%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
