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(R)-(-)-3-Chloro-1,2-propanediol

(R)-(-)-3-Chloro-1,2-propanediol structure

CAS No.: 57090-45-6

Chemical Name:: (R)-(-)-3-Chloro-1,2-propanediol

Synonyms: (R)-3-CHLOROPROPANE-1,2-DIOL;(R)-3-CHLORO-1,2-PROPANEDIOL;2-propanediol;(R)-3-ChL;(R)-3-MCPD;(R)-(-)-3-Chloro-1;R-Chloropropanediol;oro-1,2-propanedioL;(R)-(-)-3-Chloro-1,2;Chloropropanediol,98%

CBNumber:: CB8194510

Molecular Formula:: C3H7ClO2

Molecular Weight:: 110.54

MDL Number:: MFCD00135169

MOL File:: 57090-45-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-06 11:15:39

Product description	Number	Pack Size	Price
(R)-(?)-3-Chloro-1,2-propanediol 97%, optical purity ee: 98% (GLC)	540056	5g	$95.9
(R)-(-)-3-Chloro-1,2-propanediol >96.0%(GC)	M0967	10g	$55
(R)-(-)-3-Chloro-1,2-propanediol >96.0%(GC)	M0967	25g	$91
(R)-(-)-3-Chloro-1,2-propanediol Asreported	269360	10g	$355
(R)-(-)-3-Chloro-1,2-propanediol Asreported	269360	25g	$489
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(R)-(-)-3-Chloro-1,2-propanediol Properties

Melting point	-40°C
Boiling point	213 °C(lit.)
alpha	-0.9 º (neat)
Density	1.321 g/mL at 20 °C(lit.)
vapor pressure	0.04 mm Hg ( 25 °C)
refractive index	n20/D 1.48(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Chloroform, Methanol
pka	13.28±0.20(Predicted)
form	clear liquid
Specific Gravity	1.322
color	Colorless to Brown
optical activity	[α]20/D 1°, neat
Water Solubility	soluble
BRN	2202928
InChI	1S/C3H7ClO2/c4-1-3(6)2-5/h3,5-6H,1-2H2/t3-/m0/s1
InChIKey	SSZWWUDQMAHNAQ-VKHMYHEASA-N
SMILES	OC[C@@H](O)CCl
LogP	0.5 at 25℃
CAS DataBase Reference	57090-45-6(CAS DataBase Reference)
FDA UNII	64YMO02KAE
UNSPSC Code	12352101
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06,GHS08

Signal word

Danger

Hazard statements

H290-H301-H315-H318-H330-H351-H360FD-H370-H372

Precautionary statements

P202-P234-P280-P302+P352-P304+P340+P310-P305+P351+P338

target organs

Kidney

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

25-41-68-62-36/37/38-23/25-21

Safety Statements

26-28-39-45-36/37/39

RIDADR

UN 2689 6.1/PG 3

WGK Germany

RTECS

TY4025000

HazardClass

6.1

PackingGroup

III

HS Code

29053200

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Inhalation
Acute Tox. 3 Oral
Carc. 2
Eye Dam. 1
Met. Corr. 1
Repr. 1B
Skin Irrit. 2
STOT RE 1 Oral
STOT SE 1 Oral

REACH Registrations

Active

NFPA 704

	0
4		1

(R)-(-)-3-Chloro-1,2-propanediol price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	540056	(R)-(?)-3-Chloro-1,2-propanediol 97%, optical purity ee: 98% (GLC)	57090-45-6	5g	$95.9	2026-04-30	Buy
TCI Chemical	M0967	(R)-(-)-3-Chloro-1,2-propanediol >96.0%(GC)	57090-45-6	10g	$55	2026-04-30	Buy
TCI Chemical	M0967	(R)-(-)-3-Chloro-1,2-propanediol >96.0%(GC)	57090-45-6	25g	$91	2026-04-30	Buy
Usbiological	269360	(R)-(-)-3-Chloro-1,2-propanediol Asreported	57090-45-6	10g	$355	2026-06-03	Buy
Usbiological	269360	(R)-(-)-3-Chloro-1,2-propanediol Asreported	57090-45-6	25g	$489	2026-06-03	Buy

Product number	Packaging	Price	Buy
540056	5g	$95.9	Buy
M0967	10g	$55	Buy
M0967	25g	$91	Buy
269360	10g	$355	Buy
269360	25g	$489	Buy

(R)-(-)-3-Chloro-1,2-propanediol Chemical Properties,Uses,Production

Chemical Properties

clear light yellow liquid

Uses

(R)-(-)-3-Chloro-1,2-propanediol is used as a reagent in the synthesis of PA-824, which is a promising antituberculosis drug candidate that has been synthesized. It is also used in the manufacture of L-carnitine, which is a quaternary ammonium compound involved in metabolism in most mammals, plants, and some bacteria.

Definition

ChEBI: The (R)-stereoisomer of 3-chloro-1,2-propanediol.

Antimicrobial activity

(R)-(-)-3-Chloro-1,2-propanediol has been shown to be active against bacterial strains such as corynebacterium and coryneform bacteria.

Health Hazard

The toxicological evaluation revealed that (R)-(-)-3-Chloro-1,2-propanediol was genotoxic in humans and had anti-fertility effects in male rats. The discharge of this compound into wastewater might cause serious environmental hazards[1].

Synthesis

Method 1 (CN202111237118.2):

After mixing and reacting (R)epichlorohydrin, (RR)Salen cobalt(III) catalyst completely, diluting with water, filtering, separating out the precipitate of (RR)Salen cobalt(III) catalyst, and then distilling the water under reduced pressure, and then distilling under reduced pressure to obtain (R)-3-chloro-1,2-propanediol. The (R)-3-chloro-1,2-propanediol prepared by this method has a chemical purity of >99.5% and a chiral purity (EE) of >99.8%, and has the advantages of simple synthesis, low cost, and easy to be applied industrially.

Method 2 (CN201510206172.9):

1) In the presence of an acidic catalyst, (S)-3-chloro-1,2-epoxypropane and water were subjected to a ring-opening reaction to obtain a ring-opening mixture;

2) The base was subjected to a neutralization reaction with the ring-opening mixture to obtain the neutralized mixture;

3) The alkali was neutralized with the ring-opening mixture to obtain the ring-opening mixture;

4) The base was subjected to the ring-opening reaction with the ring-opening mixture;

5) The alkali was subjected to the ring-opening mixture. p>

3) Removing water from the neutralization mixture and filtering to obtain the filtrate;

4) Fractionating the filtrate at 30-35 pa and 125-128C to produce (R)-3-chloro-1,2-propanediol.

This method has excellent yields, and the (R)-3-chloro-1,2-propanediol has excellent total purity and low water content, especially the chiral purity can be as high as 99.5%.

References

[1] Yun‐Xu Yang. “Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine.” Journal of Chemical Research-s 93 1 (2011): 371–372.

(R)-(-)-3-Chloro-1,2-propanediol synthesis

Synthesis of (R)-(-)-3-Chloro-1,2-propanediol from (R)-(-)-Epichlorohydrin

(R)-(-)-3-Chloro-1,2-propanediol Preparation Products And Raw materials

Raw materials

1-chloro-3-hydroxyacetone (S)-(+)-3-Chloro-1,2-propanediol (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE

Preparation Products

(R)-(-)-Epichlorohydrin (S)-(+)-Epichlorohydrin (R)-3-Chloro-2-hydroxypropyl 4-Methoxybenzoate

(R)-(-)-3-Chloro-1,2-propanediol Suppliers

Global( 418)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2163	58
JiangXi Bobert Imp&Exp Co.,LTD	18071643627	rze2024@163.com	China	226	58
Jiangsu Nengyue New Material Technology Co.,Ltd	+86-13376001577	robinlu.jian@foxmail.com	China	64	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5216	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Nantong Provichem Biotech Co., Ltd.	+8617505220108	sales@provichem.cn	China	97	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14034	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55

Supplier	Advantage
Changzhou Ditong Chemical Co.,Ltd	58
JiangXi Bobert Imp&Exp Co.,LTD	58
Jiangsu Nengyue New Material Technology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Nantong Provichem Biotech Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55

Synthesis and Condensation reaction of (R)-(-)-3-Chloro-1,2-propanediol
(R)-(-)-3-Chloro-1,2-propanediol has a wide range of applications in the pharmaceutical and chemical manufacturing fields.
Mar 28，2026

View Lastest Price from (R)-(-)-3-Chloro-1,2-propanediol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-14	(R)-3-Chloro-1,2-propanediol 57090-45-6	$9.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-08-14	(R)-(-)-3-Chloro-1,2-propanediol 57090-45-6	$4.00	1kg	99%	200mt	Jinan Finer Chemical Co., Ltd
2026-08-13	(R)-(-)-3-Chloro-1,2-propanediol 57090-45-6	$10.00	1kg	≥98%	20 tons	Nantong Provichem Biotech Co., Ltd.

(R)-3-Chloro-1,2-propanediol
57090-45-6
$9.00
99%
Henan Fengda Chemical Co., Ltd

(R)-(-)-3-Chloro-1,2-propanediol
57090-45-6
$4.00
99%
Jinan Finer Chemical Co., Ltd

(R)-(-)-3-Chloro-1,2-propanediol
57090-45-6
$10.00
≥98%
Nantong Provichem Biotech Co., Ltd.

(R)-(-)-3-Chloro-1,2-propanediol Spectrum

(R)-(-)-3-Chloro-1,2-propanediol(57090-45-6)¹HNMR

57090-45-6((R)-(-)-3-Chloro-1,2-propanediol)Related Search:

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(R)-3-Chloro-1,2-propanediol, 95+% R - 3 - chloro - 1, 2 - propylene glycol (R)-(-)-3-Chloro-1,2-propanediol (2R)-3-chloro-1,2-propanediol (R)-(-)-3-Chloro-1,2-propanediol, 98%, ee: 99% (R)-Chloro-1,2-propanediol GLYCEROL (R)-(-)-ALPHA-MONOCHLOROHYDRIN (R)-GLYCEROL ALPHA-MONOCHLOROHYDRIN (R)-(-)-ALPHA-CHLOROHYDRIN (R)-ALPHA-GLYCEROL CHLOROHYDRIN (R)-(-)-ALPHA-MONOCHLOROHYDRIN (R)-(-)-3-CHLORO-1,2-PROPANEDIOL (R)-(-)-3-GLYCEROL ALPHA-MONOCHLOROHYDRIN (2R)-3-CHLOROPROPANE-1,2-DIOL (R)-α-Glycerol chlorohydrin (R)-(-)-3-Chloro-1,2-propanediol 97%, optical purity ee: 98% (GLC) (R)-α-Glycerol chlorohydrin (R)-(-)-3-Glycerol alpha-monochlorohydrin (R)-(-)-alpha-Monochlorohydrin Chloropropanediol,98% (R)/(S)-3-Chloro-1,2-Propanediol (-)-α-monochlorohydrine (R)-3-MCPD (R)-(-)-3-Chloro-1,2-propanediol, 97%, ee 98% R-Chloropropanediol (R)-(-)-3-CHLORO-1,2-PROPANEDIOL , EE 98% R-3-CHLOROPROPANE DIOL (R)-3-CHLORO-1,2-PROPANEDIOL ,98%MIN (R)-(-)-3-Chloro-1,2-propanediol,98% (R)-(-)-3-Chloro-1 2-propanediol R(-)3-Chloro-1,3-propanediol 1,2-Propanediol, 3-chloro-, (2R)- (R)-(-)-3-Chloro-1,2-propanediol, ee: 99% (R)-(-)-alpha-Chlorohydrin Glycerol (R)-(-)-alpha-Monochlorohydrin (R)-(-)-alpha-Monochlorohydrin (R)-(-)-3-Chloro-1,2 (R)-3-ChL oro-1,2-propanedioL (R)-3-Chloro-1,2-propanediol cas 57090-45-6 (R)-(-)-3-Chloro-1,2-propanediol> Epichlorohydrin Impurity 6 (R)-(-)-3-Chloro-1,2-propanedi (R)-(-)-3-CHLORO-1,2-PROPANEDIOL 57090-45-6 (R)-(-)-3-CHLORO-l,2-PROPANEDIOL R-(-)-3-Chloro-1,2-propanediol R-3-Chloropropanediol (R)-(-)-3-CHLORO-1,2-PROPANEDIAL (R)-(-)-3-Chloro-1,2-propanediol,NA Quizalofop Impurity 4 (R)-(-)-3-Chloro-1,2-propanediol in methanol (R)-3-CHLOROPROPANE-1,2-DIOL (R)-3-CHLORO-1,2-PROPANEDIOL 57090-45-6 57095-45-6 57090-46-9 57094-45-6 4985-47-5 ClC3H7O2 C3H7ClO2 Polyols Organic Building Blocks