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(R)-(+)-Glycidol

(R)-(+)-Glycidol structure

CAS No.: 57044-25-4

Chemical Name:: (R)-(+)-Glycidol

Synonyms: (R)-Oxiran-2-ylMethanol;(R)-GLYCIDOL;(R)-Oxiranemethanol;EOS-60676;R-Glycidoe;(R)-(+)-GL;(+)-Glycidol;(R)-GLYCIDOL,99%;(R)-(+)-GLYCIDOL;(r)-oxiranemethano

CBNumber:: CB5205831

Molecular Formula:: C3H6O2

Molecular Weight:: 74.08

MDL Number:: MFCD00074873

MOL File:: 57044-25-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:16:45

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(R)-(+)-Glycidol Properties

Boiling point	56-57 °C11 mm Hg(lit.)
Density	1.116 g/mL at 20 °C(lit.)
refractive index	n20/D 1.43(lit.)
Flash point	178 °F
storage temp.	-20°C
Water Solubility	Completely miscible in water
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	14.62±0.10(Predicted)
color	Colorless to Light yellow
optical activity	[α]23/D +15°, neat
BRN	79782
Stability	Moisture Sensitive
InChI	1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2/t3-/m1/s1
InChIKey	CTKINSOISVBQLD-GSVOUGTGSA-N
SMILES	OC[C@@H]1CO1
CAS DataBase Reference	57044-25-4(CAS DataBase Reference)
NIST Chemistry Reference	Oxiranemethanol, (R)-(57044-25-4)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06,GHS07,GHS08

Signal word

Danger

Hazard statements

H227-H315-H319-H335-H361-H370-H373-H242-H302-H312-H314-H331-H341-H350-H360F-H302+H312-H330

Precautionary statements

P201-P280-P305+P351+P338-P310-P260-P284-P202-P210-P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P311-P305+P351+P338+P337+P313-P307+P311-P403+P233-P405-P501

target organs

Respiratory system

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

T,E

Risk Statements

45-60-2-21/22-23-34-68-41-37/38

Safety Statements

53-45-36/37/39-26

RIDADR

UN 2922 8/PG 2

WGK Germany

RTECS

RR0508000

10-21

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

29109000

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

Hazard Classifications

Acute Tox. 2 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Carc. 1B
Eye Dam. 1
Muta. 2
Repr. 1B
Self-react. C
Skin Corr. 1B
STOT SE 3

REACH Registrations

Inactive

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

(R)-(+)-Glycidol price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	480819	(R)-(+)-Glycidol 97%, optical purity ee: 98% (GLC)	57044-25-4	1g	$50.1	2023-06-20	Buy
TCI Chemical	G0363	(R)-(+)-Glycidol >98.0%(GC)	57044-25-4	5g	$70	2026-04-30	Buy
TCI Chemical	G0363	(R)-(+)-Glycidol >98.0%(GC)	57044-25-4	25g	$235	2026-04-30	Buy
Usbiological	463594	(R)-(+)-Glycidol ≥97%	57044-25-4	5g	$403	2026-06-03	Buy
Usbiological	463594	(R)-(+)-Glycidol ≥97%	57044-25-4	10g	$566	2026-06-03	Buy

Product number	Packaging	Price	Buy
480819	1g	$50.1	Buy
G0363	5g	$70	Buy
G0363	25g	$235	Buy
463594	5g	$403	Buy
463594	10g	$566	Buy

(R)-(+)-Glycidol Chemical Properties, Uses, Production

Synthesis

Under stirring, NaOH (36.19 g, 0.905 mol) was slowly added to a solution of chlorodiol (100.0 g, 0.905 mol) and ethanol (200 mL) at 0-5°C. The reaction mixture was then stirred at 0-5°C for 2 hours. After the reaction was complete, the reaction mixture was filtered to remove the insoluble solid precipitate. The filtrate was concentrated under vacuum at 40°C to obtain the target product (R)-(+)-Glycidol (note that (R)-(+)-Glycidol has a low boiling point and requires low-temperature treatment during vacuum concentration in post-processing).

Synthesis of 57044-25-4

Figure: Synthetic route of (R)-(+)-Glycidol

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(+)-Glycidol may be used in the following synthesis:

heteroarylpropane-2,3-diols, useful for combinatorial oligomer synthesis
enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and -hydroxyphenylalaninol
2-amino-1,4-anhydro-pentitol and 3-amino-1,5-anhydro-4-deoxy-hexitol with the arabino configuration
(S)-4-tosyloxymethyl-2-oxazolidinone, required for the synthesis of protected amino alcohol derivatives
1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine [(S)-HPMPC]
chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product

Uses

(R)-(+)-Glycidol can be used to construct chiral building blocks of epoxyvinyl iodide intermediates in the synthesis of furanocembrane, a marine natural product.

Definition

ChEBI: (R)-glycidol is a glycidol. It is functionally related to a (R)-1,2-epoxypropane. It is an enantiomer of a (S)-glycidol.

General Description

Enantioselective esterification of (R)-(+)-glycidol with n-butyric acid in organic media using hybrid gel-entrapped lipase on Celite has been reported.

Purification Methods

[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

(R)-(+)-Glycidol Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(+)-Methyl glycidyl ether (S)-(+)-Glycidyl butyrate 1,2-Propanediol, 3-(dodecyloxy)-, (2R)- (S)-2-((2-Fluorophenoxy)methyl)oxirane

(R)-(+)-Glycidol Suppliers

Global Suppliers ( 315)

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Huaren Chemical Co., Ltd	0519-88103998, 13646148298, 88103997, 88122965,88100916 13646148298;051988100916;	amy.zhou@huarenchem.com	China	51	63
Sichuan Hainuowei Technology Co. Ltd.	13708085536 13708085536	hanovichem@163.com	China	3268	56
Shandong Shining Pharm Co.,Ltd	18866891188 18866891188	zhaojiangxia@shiningpharm.com	China	203	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing dtftchem Technology Co., Ltd.	010-60275820 13031183356	elainezt@sina.com	China	1386	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Changzhou Huaren Chemical Co., Ltd	63
Sichuan Hainuowei Technology Co. Ltd.	56
Shandong Shining Pharm Co.,Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Beijing dtftchem Technology Co., Ltd.	62
Energy Chemical	61

View Latest Price from (R)-(+)-Glycidol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	(R)-(+)-Glycidol 57044-25-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-08-06	(R)-(+)-Glycidol 57044-25-4	$1.00	1KG	95%-99%	2000kg	Career Henan Chemical Co

(R)-(+)-Glycidol
57044-25-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-(+)-Glycidol
57044-25-4
$1.00
95%-99%
Career Henan Chemical Co

(R)-(+)-Glycidol Spectrum

(R)-(+)-Glycidol(57044-25-4)¹HNMR (R)-(+)-Glycidol(57044-25-4)FT-IR (R)-(+)-Glycidol(57044-25-4)Raman

57044-25-4 ((R)-(+)-Glycidol) Related Search:

Methanol Allyl glycidyl ether Ethylene glycol diglycidyl ether DIGLYCIDYL ETHER Propylene oxide

Chlorophosphonazo III Ethylene oxide 1,2,3-Propanetriol glycidyl ether Glycidyl methyl ether BISPHENOL A DIGLYCIDYL ETHER RESIN

Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate Cinobufotalin Cinobufagin (S)-Glycidol 3-Nitrobenzenesulfonate (S)-(+)-Benzyl glycidyl ether

(2S)-(+)-Glycidyl tosylate Glycidol Glycidyl phenyl ether

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EOS-60676 (r)-oxiranemethano (R)-(+)-2,3-EPOXY-1-PROPANOL (R)-(+)-GLYCIDOL R(+)-OXIRANE-2-METHANOL (R)-Oxiranemethanol OXIRANEMETHANOL, (2R)- (R)-GLYCIDOL,99% (R)-3-Hydroxy-1,2-epoxypropane (R)-(+)-GLYCIDOL, 97% (98% EE/GLC) R-Glycidoe (R)-(+)-GLYCIDOL ((R)-(+)-2,3-EPOXY-1-PROPANOL) (2R)-Oxirane-2-methanol (R)-2-Hydroxymethyloxirane (R)-(+)-Glycidol,(R)-(+)-Oxirane-2-methanol (R)-(+)-1-Hydroxy-2,3-epoxypropane (R)-(+)-2-(Hydroxymethyl)oxirane (R)-(+)-Glycidol 97%, optical purity ee: 98% (GLC) 2-Oxiranemethanol, (2R)- (R)-(+)-1-Hydroxy-2,3-epoxypropane (R)-(+)-Glycidol≥ 99% (GC) (R)-(+)-Oxirane-2-methanol (R)-(+)-1-Hydroxy-2,3-epoxypropane (R)-(+)-2-(Hydroxymethyl)oxirane (R)-(+)-Glycidol> (R)-(+)-GL 97%, optical purity ee: 98% (GLC) (+)-Glycidol Levodropropazine impurity 11 (R)-(+)-Glycidol (R)-(+)-Glycidol, 97% (2R)-(+)-2-(Hydroxymethyl)oxirane (R)-Oxiran-2-ylMethanol (R)-GLYCIDOL (R)-(+)-Glycidol(>90%) 57044-25-4 C3H6O2 Asymmetric Synthesis Chiral Building Blocks Organic Building Blocks Epoxides Chiral Compound CHIRAL COMPOUNDS chiral API intermediates