Heat Shock Protein Inhibitor II
- CAS No.
- 1859-42-3
- Chemical Name:
- Heat Shock Protein Inhibitor II
- Synonyms
- 3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one;2-Pyrrolidinone, 3-(1,3-benzodioxol-5-ylmethylene)-;3-(Benzo[d][1,3]dioxol-5-ylmethylene)pyrrolidin-2-one
- CBNumber:
- CB53136752
- Molecular Formula:
- C12H11NO3
- Molecular Weight:
- 217.22
- MDL Number:
- MFCD19104819
- MOL File:
- 1859-42-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Heat Shock Protein Inhibitor II price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 1859-42-3 | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 1859-42-3 | 10mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 1859-42-3 | 25mg | $402 | 2026-04-30 | Buy |
| ChemScene | CS-0063682 | KNK423 | 1859-42-3 | 5mg | $200 | 2026-06-04 | Buy |
| ChemScene | CS-0063682 | KNK423 | 1859-42-3 | 10mg | $320 | 2026-06-04 | Buy |
Heat Shock Protein Inhibitor II Chemical Properties, Uses, Production
Description
Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B (AmB; ) increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.
Uses
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
References
[1] Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9. PMID:11205912
[2] Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88. DOI:10.1128/AAC.05164-14
Heat Shock Protein Inhibitor II Preparation Products And Raw materials
Raw materials
Preparation Products
Heat Shock Protein Inhibitor II Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11432 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
View Latest Price from Heat Shock Protein Inhibitor II manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | Heat Shock Protein Inhibitor II
1859-42-3
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
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- Heat Shock Protein Inhibitor II
1859-42-3
- $1.00
- 99%
- Career Henan Chemical Co
