Heat Shock Protein Inhibitor II
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- $103 - $402
- Product name: Heat Shock Protein Inhibitor II
- CAS: 1859-42-3
- MF: C12H11NO3
- MW: 217.22
- EINECS:
- MDL Number:MFCD19104819
- Synonyms:3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one;3-(Benzo[d][1,3]dioxol-5-ylmethylene)pyrrolidin-2-one;2-Pyrrolidinone, 3-(1,3-benzodioxol-5-ylmethylene)-
8 prices
Selected condition：
Brand
- aablocks
- Cayman Chemical
- ChemScene
Package
- 5mg
- 10mg
- 25mg
- Manufactureraablocks
- Product numberAA00JNOD
- Product descriptionKNK423 ≥98%
- Packaging25mg
- Price$402
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNOD
- Product descriptionKNK423 ≥98%
- Packaging10mg
- Price$183
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNOD
- Product descriptionKNK423 ≥98%
- Packaging5mg
- Price$103
- Updated2026-05-29
- Buy
- ManufacturerCayman Chemical
- Product number22358
- Product descriptionHeat Shock Protein Inhibitor II ≥98%
- Packaging25mg
- Price$402
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22358
- Product descriptionHeat Shock Protein Inhibitor II ≥98%
- Packaging5mg
- Price$103
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22358
- Product descriptionHeat Shock Protein Inhibitor II ≥98%
- Packaging10mg
- Price$183
- Updated2026-04-30
- Buy
- ManufacturerChemScene
- Product numberCS-0063682
- Product descriptionKNK423
- Packaging5mg
- Price$200
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0063682
- Product descriptionKNK423
- Packaging10mg
- Price$320
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00JNOD | KNK423 ≥98% | 25mg | $402 | 2026-05-29 | Buy |
| aablocks | AA00JNOD | KNK423 ≥98% | 10mg | $183 | 2026-05-29 | Buy |
| aablocks | AA00JNOD | KNK423 ≥98% | 5mg | $103 | 2026-05-29 | Buy |
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 25mg | $402 | 2026-04-30 | Buy |
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 22358 | Heat Shock Protein Inhibitor II ≥98% | 10mg | $183 | 2026-04-30 | Buy |
| ChemScene | CS-0063682 | KNK423 | 5mg | $200 | 2026-06-04 | Buy |
| ChemScene | CS-0063682 | KNK423 | 10mg | $320 | 2026-06-04 | Buy |
Properties
Melting point :249-250 °C
Boiling point :466.9±45.0 °C(Predicted)
Density :1.355±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml
form :A crystalline solid
pka :14.65±0.20(Predicted)
Boiling point :466.9±45.0 °C(Predicted)
Density :1.355±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.1 mg/ml
form :A crystalline solid
pka :14.65±0.20(Predicted)
Safety Information
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Description
Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B (AmB; ) increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.Related product price
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