5-Chloro-3-iodo-1H-indazole
- CAS No.
- 351456-45-6
- Chemical Name:
- 5-Chloro-3-iodo-1H-indazole
- Synonyms
- 351456-46-5;5-CHLORO-3-IODOINDAZOLE;5-Chloro-3-iodo-1H-indazole;5-chloro-3-iodo-2H-indazole;1H-Indazole, 5-chloro-3-iodo-
- CBNumber:
- CB5322673
- Molecular Formula:
- C7H4ClIN2
- Molecular Weight:
- 278.48
- MDL Number:
- MFCD06739146
- MOL File:
- 351456-45-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
5-Chloro-3-iodo-1H-indazole price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 22008 | 5-CHLORO-3-IODO-1H-INDAZOLE 97% | 351456-45-6 | 1G | $80 | 2026-04-30 | Buy |
| AstaTech | 22008 | 5-CHLORO-3-IODO-1H-INDAZOLE 97% | 351456-45-6 | 5G | $285 | 2026-04-30 | Buy |
| Activate Scientific | AS50939 | 5-Chloro-3-iodo-1H-indazole 96% | 351456-45-6 | 1g | $48 | 2026-06-04 | Buy |
| Activate Scientific | AS50939 | 5-Chloro-3-iodo-1H-indazole 96% | 351456-45-6 | 5g | $145 | 2026-06-04 | Buy |
| Apolloscientific | OR60117 | 5-Chloro-3-iodo-1H-indazole ≥95% | 351456-45-6 | 500mg | $21 | 2026-06-04 | Buy |
5-Chloro-3-iodo-1H-indazole Chemical Properties,Uses,Production
Synthesis
698-26-0
351456-45-6
General procedure for the synthesis of 3-iodo-5-chloroindazole from 5-chloro-1H-indazole: the direct iodination reaction was carried out by referring to the method previously reported by Bocchi [28] with slight modifications. The procedure was as follows: 5-chloro-1H-indazole (3 g, 25.4 mmol), iodine (12.7 g, 50.03 mmol) and potassium hydroxide (5.34 g, 95.25 mmol) were dissolved in DMF (7 mL) and the reaction was stirred for 3 h at room temperature. Upon completion of the reaction, the reaction was quenched with saturated sodium bisulfite solution (150 mL), at which time a precipitate was generated. The precipitate was collected by vacuum filtration and washed with water three times (30 mL each). The resulting solid was dried in a vacuum oven at 30 °C overnight to give 6.17 g of the light yellow solid product 3-iodo-5-chloroindazole. Yield: 100%; Melting point: 136-138 °C (literature value:[36] 134-136 °C); IR (KBr) ν (cm^-1): 3086 (NH); 424 (C-I). 1H-NMR δ (ppm): 13.50 (1H, s, H-1); 7.55 (1H, d, J=8.6 Hz, H-7); 7.45- 7.40 (2H, m, H-6 and H-4); 7.19 (1H, dd, J=7.5Hz, H-5).13C-NMR δ (ppm): 140.41; 127.22; 126.79; 121.23; 120.39; 110.51; 93.49. HRMS calculated value C7H4ClIN2: 277.9107 , measured value: 277.9109.
References
[1] Molecules, 2018, vol. 23, # 8,
[2] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00208
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2793 - 2800
5-Chloro-3-iodo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
View Lastest Price from 5-Chloro-3-iodo-1H-indazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-14 | 5-CHLORO-3-IODO-1H-INDAZOLE
351456-45-6
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 5-CHLORO-3-IODO-1H-INDAZOLE
351456-45-6
- $9.80
- ≥99%
- Career Henan Chemical Co
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