ChemicalBook >> CAS DataBase List >>2,3,3-Trimethyl-5-methoxy-3H-indole

2,3,3-Trimethyl-5-methoxy-3H-indole

CAS No.
31241-19-7
Chemical Name:
2,3,3-Trimethyl-5-methoxy-3H-indole
Synonyms
5-methoxy-2,3,3-trimethylindole;2,3,3-Trimethyl-5-methoxyindole;2,3,3-TRIMETHYL-5-METHOXY-3H-INDOLE;5-METHOXY-2,3,3-TRIMETHYL-3H-INDOLE;2,3,3-Trimethyl 5-Methoxy Indolenine;3H-Indole,5-Methoxy-2,3,3-triMethyl-;2,3,3-TRIMETHYL-5-METHOXY-3H-INDOLE,98+%
CBNumber:
CB5324440
Molecular Formula:
C12H15NO
Molecular Weight:
189.25
MDL Number:
MFCD04972105
MOL File:
31241-19-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 17:45:09

2,3,3-Trimethyl-5-methoxy-3H-indole Properties

Boiling point 286.7±40.0 °C(Predicted)
Density 1.04±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka 6.60±0.40(Predicted)
Appearance Light yellow to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
HS Code  2916399090

2,3,3-Trimethyl-5-methoxy-3H-indole price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 290666 2,3,3-Trimethyl 5-methoxy indolenine Asreported 31241-19-7 250mg $408 2026-06-03 Buy
Usbiological 290666 2,3,3-Trimethyl 5-methoxy indolenine Asreported 31241-19-7 500mg $573 2026-06-03 Buy
Usbiological 290666 2,3,3-Trimethyl 5-methoxy indolenine Asreported 31241-19-7 1g $797 2026-06-03 Buy
Usbiological 290666 2,3,3-Trimethyl 5-methoxy indolenine Asreported 31241-19-7 2g $1111 2026-06-03 Buy
Usbiological 290666 2,3,3-Trimethyl 5-methoxy indolenine Asreported 31241-19-7 5g $1573 2026-06-03 Buy
Product number Packaging Price Buy
290666 250mg $408 Buy
290666 500mg $573 Buy
290666 1g $797 Buy
290666 2g $1111 Buy
290666 5g $1573 Buy

2,3,3-Trimethyl-5-methoxy-3H-indole Chemical Properties,Uses,Production

Uses

2,3,3-Trimethyl-5-methoxy-3H-indole is used as a key intermediate in the synthesis of the spirane copper ion sensor SP1 [1].

Synthesis

2,3,3-Trimethyl-5-methoxy-3H-indole was prepared by refluxing 4-methoxyphenylhydrazine hydrochloride with 3-methylbutan-2-one in a solution of glacial acetic acid for 5.5 hours. The specific reaction steps are as follows: 4-methoxyphenylhydrazine hydrochloride (4.815 g, 27.57 mmol) was added to a solution containing 3-methylbutan-2-one (5.90 mL, 55.2 mmol) in glacial acetic acid (88 mL). The solution was stirred at reflux for 5.5 h. The solution was allowed to cool to room temperature and neutralized with KOH pellets. The crude material was extracted with Et2O (3 × 100 mL), dried over MgSO4, filtered, and concentrated in vacuo. The crude product was purified by flash column chromatography (70:30, hexanes/ EtOAc) to afford 2,3,3-trimethyl-5-methoxy-3H-indole as a red amorphous solid (5.149 g, 99%) [1].

References

[1] Trevino, K. M., Tautges, B. K., Kapre, R. (2021). Highly Sensitive and Selective Spiropyran-Based Sensor for Copper(II) Quantification. ACS Omega, 6 16, 10776–10789. https://doi.org/10.1021/acsomega.1c00392

563-80-4
3471-32-7
31241-19-7
Synthesis of 2,3,3-Trimethyl-5-methoxy-3H-indole from 3-Methyl-2-butanone and (4-methoxyphenyl)hydrazine
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View Lastest Price from 2,3,3-Trimethyl-5-methoxy-3H-indole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3,3-Trimethyl-5-methoxy-3H-indole pictures 2024-07-20 2,3,3-Trimethyl-5-methoxy-3H-indole
31241-19-7
$1.00 1Kg 98% 20T Shaanxi Dideu Medichem Co. Ltd
2,3,3-Trimethyl-5-methoxy-3H-indole pictures 2019-07-06 2,3,3-Trimethyl-5-methoxy-3H-indole
31241-19-7
$1.00 1kg 99% 200kg Career Henan Chemical Co

2,3,3-Trimethyl-5-methoxy-3H-indole Spectrum

5-METHOXY-2,3,3-TRIMETHYL-3H-INDOLE 2,3,3-TRIMETHYL-5-METHOXY-3H-INDOLE 2,3,3-Trimethyl 5-Methoxy Indolenine 2,3,3-TRIMETHYL-5-METHOXY-3H-INDOLE,98+% 2,3,3-Trimethyl-5-methoxyindole 3H-Indole,5-Methoxy-2,3,3-triMethyl- 5-methoxy-2,3,3-trimethylindole 31241-19-7 Heterocycle-Indole series