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ChemicalBook >> CAS DataBase List >>3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Structure
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone structure
CAS No.
22246-18-0
Chemical Name:
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Synonyms
7-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE;7-HYDROXY-3,4-DIHYDROCARBOSTYRIL;7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE;7-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;Aripiprazole EP Impurity A;7-Hydroxy-3;AURORA KA-4813;Aripiprazole Imp.A;3,4-Dihydro-7-hydrox;7-Hydroxy carbostyril
CBNumber:
CB5325629
Molecular Formula:
C9H9NO2
Molecular Weight:
163.17
MDL Number:
MFCD06410891
MOL File:
22246-18-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Properties

Melting point 233-237 °C
Boiling point 403.7±45.0 °C(Predicted)
Density 1.282±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 9.60±0.20(Predicted)
color Pale Yellow
InChI InChI=1S/C9H9NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1,3,5,11H,2,4H2,(H,10,12)
InChIKey LKLSFDWYIBUGNT-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(O)=C2)CCC1=O
CAS DataBase Reference 22246-18-0(CAS DataBase Reference)
FDA UNII VFU6XCR3Q3
UNSPSC Code 41116100
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280-P301+P312+P330-P302+P352
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-43
Safety Statements  36/37
WGK Germany  3
HS Code  29334900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1
NFPA 704
1
2 0

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 675369 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97% 22246-18-0 1g $28.5 2026-04-30 Buy
TCI Chemical D3599 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) 22246-18-0 5g $20 2026-04-30 Buy
TCI Chemical D3599 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone >98.0%(HPLC)(N) 22246-18-0 25g $43 2026-04-30 Buy
Biosynth FD22021 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 22246-18-0 0.25kg $162.25 2026-06-04 Buy
Biosynth FD22021 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 22246-18-0 0.5kg $259.6 2026-06-04 Buy
Product number Packaging Price Buy
675369 1g $28.5 Buy
D3599 5g $20 Buy
D3599 25g $43 Buy
FD22021 0.25kg $162.25 Buy
FD22021 0.5kg $259.6 Buy

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Chemical Properties, Uses, Production

Synthesis

Synthesis of 22246-18-0


(1) 3-Chloro-N-(3-hydroxyphenyl)propionamide
Dissolve 20 mmol of m-aminophenol in dichloromethane, add 20 mmol of triethylamine dropwise, and add 22 mmol of 3-chloropropionyl chloride dropwise while stirring at room temperature. After the addition is complete, stir at room temperature for 10 h. Wash three times with deionized water, and separate the organic phase by column chromatography to obtain 68% 3-chloro-N-(3-hydroxyphenyl)propionamide. (2) 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
10 mmol of 3-chloro-N-(3-hydroxyphenyl)propionamide, 40 mmol of aluminum trichloride, and 6 mmol of N,N-dimethylacetamide were placed in a three-necked flask and reacted at 150 °C for 5 hours. 20 mL of ice water was slowly added dropwise to cool the mixture. The mixture was then heated to 90 °C and stirred for 1 hour. After cooling to room temperature, the mixture was filtered to obtain a red solid. Column chromatography yielded 88% 3,4-dihydro-7-hydroxy-2(1H)-quinolinone.

Description

3,4-Dihydro-7-hydroxy-2 (1H)-quinolinone is a useful organic and pharmaceutical intermediate. It can be used as the precursor of aripiprazole1, which is an antipsychotic medication. It is also an antitumor agent and hydroxyindole analog inhibitor tyrosinase melanoma.

Chemical Properties

Pale Yellow Powder

Uses

3,4-Dihydro-7-hydroxyquinoline-2(1H)-one (Aripiprazole EP Impurity A) is an antitumor agent. Hydroxyindole analog inhibitor tyrosinase melanoma. This compound is also used in the preparation of aripiprazole (A771000).

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

7-Methoxy-3,4-dihydro-1H-quinolin-2-one 3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone 6-Bromo-7-ethoxy-1,2,3,4-tetrahydroquinolin-2-one 7-(Benzyloxy)-3,4-dihydrocarbostyril 7-(4-BroMobutoxy)-3,4-dihydroquinolin-2-one-d8

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Suppliers

Global Suppliers ( 739)
Supplier Tel Email Country ProdList Advantage
Hangzhou Great Forest Biomedical Ltd. 0571-28313180 17767135330 info@great-forest.com China 55 58
Beijing Whale Technology Corporation Ltd. 010-83694934 13671295325 sales@whalecorporation.com China 107 58
xiamen hongyi 18060930853 18060930853@163.com China 16 58
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 1846 58
Shaanxi Zhong Zhi Biao Pin Pharmaceutical technology Co., LTD 029-89239927 18009291534 18009291534@163.com China 376 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
Hangzhou Great Forest Biomedical Ltd. 58
Beijing Whale Technology Corporation Ltd. 58
xiamen hongyi 58
Suzhou Highfine Biotech Co., Ltd 58
Shaanxi Zhong Zhi Biao Pin Pharmaceutical technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

View Latest Price from 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone pictures 2026-09-15 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
22246-18-0
 $23.00 1kg 99% 20MT Jinan Finer Chemical Co., Ltd
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone pictures 2026-09-11 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
22246-18-0
 1KG 98%min 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
3,4-Dihydro-7-hydroxy-2(1H)-quinolinone pictures 2026-09-02 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
22246-18-0
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Spectrum

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone(22246-18-0)MS3,4-Dihydro-7-hydroxy-2(1H)-quinolinone(22246-18-0)1HNMR3,4-Dihydro-7-hydroxy-2(1H)-quinolinone(22246-18-0)IR13,4-Dihydro-7-hydroxy-2(1H)-quinolinone(22246-18-0)IR2

22246-18-0 (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) Related Search:

4'-Hydroxyacetophenone Quinhydrone 2'-Hydroxyacetophenone 2-Quinolinol Tetrahydro-4H-pyran-4-one
Neosperidin dihydrochalcone 1-Tetralone 8-Hydroxyquinoline Dehydroepiandrosterone 7-Hydroxyquinolinone
Chlorophosphonazo III 7-(4-Bromobutoxy)-quinoline-2(1H)-one Brexpiprazole Impurity 20 Brexpiprazole Impurity 5 HCl 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one
(E)-N-(3-Methoxy-phenyl)-3-phenyl-acrylamide 5-Hydroxy-2(1H)-quinolinone 7,7'-(butane-1,4-diylbis(oxy))bis(quinolin-2(1H)-one)

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7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Aripiprazole Dihydroquinolinone Impurity (USP) 7-Hydroxy-3,4-dihydro-2(1H)-chinolinon Intermediate of Aripiprazole Aripiprazole Impurity 13 7- hydroxy-3,4- twohydrogen -2(1H)- quinolinone 7-Hydroxy-3,4-dihydro-2(H)-quinolinone 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone SynonyMs 7-Hydroxy Carbostyril 7-Hydroxy-1,2,3,4-tetrahydro-2-chinolinon 7-HYDROXY-1,2,3,4-TETRAHYDRO-2-QUINOLINONE 7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLIN-2-ONE 7-HYDROXY-1,2,3,4-TETRAHYDROQUINOLINE-2-ONE 7-HYDROXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 7-HYDROXY-3,4-DIHYDRO-2-OXO-(1H)-QUINOLINE 7-HYDROXY-3,4-DIHYDRO CARBOSTYRYL 7-HYDROXY-3,4-DIHYDRO-QUINOLIN-2-ONE 8-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE 3,4-DIHYDRO-7-HYDROXYCARBOSTYRIL 7-Hydroxy-2(1H)-3,4-dihydroquinolinone 7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINOLINONE3,4-DIHYDRO-7-HYDROXY-2-(1H)-QUINOLINONE 3,4-Dihydro-7-Hydroxy-2(1H)-Quinlinone 7-Hydroxy-2-Oxo-3,4-Dihydroquinoline 7-Hydroxy-3,4-dihydro-2(1H)-qu 3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINONE /7-HQ 7-HYDROXY-3,4-DIHYDRO-2(1H)-QUINLINONE 7-HYDROXY-3,4-DIHYDRO-2(1H)QUINOLINONE//INTERMEDIATE OF ARIPIPRAZOLE AURORA KA-4813 (1H)-7-HYDROXY-3,4-DIHYDRO-2-QUINOLINONE Aripiprazole Imp.A 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 97% Aripiprazole Dihydroquinolinone Impurity 7-HYDROXY-2-OXO-3,4-DIHYDROQUINOLINE, 98% ARIPIPRZAOLE INTERMEDIATE 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 7-Hydroxy carbostyril 7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline 2(1H)-Quinolinone,7-hydroxy, 3,4-dihydro- 3,4-Dihydro-7-hydroxy-1H-quinolin-2-one 7-Hydroxy-3,4-dihydro-2-quinolinone 7-Hydroxy-1,2,3,4-tetrahydro-2-quinolinone, 7-Hydroxy-3,4-dihydrocarbostyril 7-Hydroxy-3,4-dihydroquinoline-2(1H)-one 3,4-Dihydro-7-hydrox 4-dihydro-quinolin-2-one 7-Hydroxy-3 7-HYDROXY-3, 4-DIHYDRO-2(1H)-QUINLIONE Aripiprazole intermediate Aripiprazole EP Impurity A(3,4-Dihydro-7-hydroxyquinoline-2(1H)-one) Aripiprazole Impurity 21（Aripiprazole EP Impurity A） 4-Dihydro-7-hydroxy-2(1H)-quinolinone 3,4-Dihydro-7-hydroxy-2(1H)-quinolinon 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone> 7-Hydroxy-3,4-dihydro-2(1H)-quinoL 7-HYDROXY-3,4-DIHYDROCARBOSTYRIL 22246-18-0 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone ISO 9001：2015 REACH Aripiprazole EP Impurity A/ Aripiprazole Dihydroquinolinone Impurity 7-hydroxy-3,4-dihydro-2(lH)-quinolinone Aripiprazole impurities1787 7-HydroxycarbostyrilQ: What is 7-Hydroxycarbostyril Q: What is the CAS Number of 7-Hydroxycarbostyril Q: What is the storage condition of 7-Hydroxycarbostyril Q: What are the applications of 7-Hydroxycarbostyril 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone, 97%,