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7-Hydroxyquinolinone

7-Hydroxyquinolinone Structure
7-Hydroxyquinolinone structure
CAS No.
70500-72-0
Chemical Name:
7-Hydroxyquinolinone
Synonyms
7-Hydroxyquinolin-2(1H)-one;quinoline-2,7-diol;7-HYDROXY-2-QUINOLINONE;2,7-DIHYDROXYQUINOLINE;7-HYDROXYQUINOLINE-2(1H)-ONE;7-Hydroxy-;7-Hydroxycarbostyril;7-hydroxyquinolinone;7-hydroxy-2(1H)-Quino;7- hydroxy-2-quinolone
CBNumber:
CB6404930
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MDL Number:
MFCD04117979
MOL File:
70500-72-0.mol
MSDS File:
SDS
Last updated:2026-05-28 05:08:59
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7-Hydroxyquinolinone Properties

Melting point 187-192°C
Boiling point 426.8±45.0 °C(Predicted)
Density 1.337±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka 9.32±0.20(Predicted)
color Off-White to Pale Yellow
Water Solubility Water: Insoluble
Major Application pharmaceutical
InChI InChI=1S/C9H7NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1-5,11H,(H,10,12)
InChIKey DBSPUDKBNOZFMX-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(O)=C2)C=CC1=O
CAS DataBase Reference 70500-72-0(CAS DataBase Reference)
FDA UNII 3B25C3NP9L
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
WGK Germany  WGK 3
HS Code  29334900
Storage Class 11 - Combustible Solids
REACH Registrations Active

7-Hydroxyquinolinone price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-H953255-5G 7-Hydroxyquinoline-(1H)-2-one 70500-72-0 5g $307 2026-06-03 Buy
TRC TRC-H953255-1G 7-Hydroxyquinoline-(1H)-2-one 70500-72-0 1g $109 2026-06-03 Buy
TRC TRC-H953255-100MG 7-Hydroxyquinoline-(1H)-2-one 70500-72-0 100mg $84 2026-06-03 Buy
Biosynth FH24500 7-Hydroxyquinoline-(1H)-2-one 70500-72-0 10g $150 2026-06-04 Buy
Biosynth FH24500 7-Hydroxyquinoline-(1H)-2-one 70500-72-0 5g $150 2026-06-04 Buy
Product number Packaging Price Buy
TRC-H953255-5G 5g $307 Buy
TRC-H953255-1G 1g $109 Buy
TRC-H953255-100MG 100mg $84 Buy
FH24500 10g $150 Buy
FH24500 5g $150 Buy

7-Hydroxyquinolinone Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

7-Hydroxyquinolone is a substituted carbostyril derivative used as a pharmaceutical intermediate. It is an impurity of aripiprazole quinolinone.

Definition

ChEBI: 7-hydroxyquinolin-2(1H)-one is a monohydroxyquinoline and a quinolone.

Synthesis

N-(CINNAMOYL)-3-METHOXYANILINE

127033-74-3

7-Hydroxyquinolinone

70500-72-0

General procedure for the synthesis of 7-hydroxyquinolin-2(1H)-one from N-(3-methoxyphenyl)cinnamamide: Aluminum trichloride (3.16 g, 23.69 mmol) was added batchwise to a suspension of chlorobenzene (30 mL) of compound 3 (1 g, 3.95 mmol) in an ice bath. The reaction mixture was gradually warmed up to 120 °C and kept at reflux for 3 hours. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure and the residue was purified by silica gel column chromatography to afford compound 4 in 54% yield.

References

[1] Synthesis, 1997, # 1, p. 87 - 90
[2] Tetrahedron Letters, 1999, vol. 40, # 24, p. 4505 - 4506
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5561 - 5578
[4] Patent: CN108101926, 2018, A. Location in patent: Paragraph 0033; 0034; 0035
[5] Patent: WO2008/24481, 2008, A2. Location in patent: Page/Page column 32

7-Hydroxyquinolinone synthesis

22246-18-0
70500-72-0
Synthesis of 7-Hydroxyquinolinone from 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

7-Hydroxyquinolinone Preparation Products And Raw materials

Raw materials

N-(Cinnamoyl)-3-methoxyaniline (E)-N-(3-Methoxy-phenyl)-3-phenyl-acrylamide 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Aluminum chloride Chlorobenzene

Preparation Products

Dehydro aripiprazole

7-Hydroxyquinolinone Suppliers

Global( 477)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing CoreTech Biomedical Co,.Ltd 025-52880806 13770327895 API@core-tech.com.cn China 52 58
Chengdu Aofan Pharmtech Co.,Ltd 15281070185; 13038283958 2865097598@qq.com China 111 55
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 13594048950 19923294409 xingcanyaoye@sina.com China 1591 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 145 61
Gansu Haotian PharmaTech Co.,Ltd. 17789447501 zhuanxiajiang@haotianpharm.com China 211 58
Anqing CHICO Pharmaceutical Co., Ltd. 18061456370 sales@chicopharm.com China 500 65
Tianjin Famoxi Biopharmaceutical Technology Co., Ltd 18522868115; 18522868115 yuqingliu@bio-pharmacn.com China 121 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 022-60189726 18812034280 188120342808@163.com China 143 61
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Nanjing CoreTech Biomedical Co,.Ltd 58
Chengdu Aofan Pharmtech Co.,Ltd 55
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. 58
Bayee Biotech (Anqing) Co., Ltd. 61
Gansu Haotian PharmaTech Co.,Ltd. 58
Anqing CHICO Pharmaceutical Co., Ltd. 65
Tianjin Famoxi Biopharmaceutical Technology Co., Ltd 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 61
J & K SCIENTIFIC LTD. 76

View Lastest Price from 7-Hydroxyquinolinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Hydroxyquinolinone pictures 2026-09-02 7-Hydroxyquinolinone
70500-72-0
 $35.00 1kg 99% Henan Fengda Chemical Co., Ltd
7-Hydroxyquinolinone pictures 2026-09-01 7-Hydroxyquinolinone
70500-72-0
 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd
7-Hydroxyquinolinone pictures 2026-08-20 7-Hydroxyquinolinone
70500-72-0
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

7-Hydroxyquinolinone Spectrum

7-Hydroxyquinolinone(70500-72-0)1HNMR

70500-72-0(7-Hydroxyquinolinone)Related Search:

4'-Hydroxyacetophenone 2-Quinolinol Quinclorac Quinhydrone Ethoxyquin
Isoquinoline 8-Hydroxyquinoline Brexpiprazole Chlorophosphonazo III 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Brexpiprazole Impurity 20 Thianaphthene Brexpiprazole Impurity
Brexpiprazole Impurity 2 7-(4-Bromobutoxy)-quinoline-2(1H)-one Brexpiprazole sulfoxide impurity

1of4

2,7-DIHYDROXYQUINOLINE 7-HYDROXYQUINOLINE-(1H)-2-ONE 3,4-Dihydro-7-hydroxyquinoline-2(1H)-one 3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINE 7-Hydroxycarbostyril 7-HYDROXY-1H-QUINOLIN-2-ONE 7-hydroxy-2-(1h)-quinolinone 7-hydroxyquinolinone 2(1H)-Quinolinone, 7-hydroxy- 7-Hydroxy- 7-hydroxy-1,2-dihydroquinolin-2-one N1-(2,3-dichlorophenyl)-N2 4-Dihydro-7-hydroxycarbostyril 7- hydroxy-2-quinolone 7-hydroxy-2(1H)-Quino 7-Hydroxyquinolinone ISO 9001：2015 REACH Aripiprazole impurities1777 Aripiprazole Quinolinone ImpurityQ: What is Aripiprazole Quinolinone Impurity Q: What is the CAS Number of Aripiprazole Quinolinone Impurity Q: What is the storage condition of Aripiprazole Quinolinone Impurity Q: What are the applications of Aripiprazole Quinolinone Impurity Aripiprazole Quinolinone Impurity 7-Hydroxyquinoline-(1H)-2-one , 7-Hydroxy-2(1H)-quinolinone Brexpiprazole Dimer Impurity 6 7-Hydroxycarbostyril, 10 mM in DMSO 7-Hydroxy-2(1H)-quinolinone Aripiprazole Hydroxyquinolinone Analog 7-HYDROXYQUINOLINE-2(1H)-ONE 7-Hydroxyquinolin-2(1H)-one 7-HYDROXY-2-QUINOLINONE quinoline-2,7-diol 70500-72-0 142858-02-5 Aromatics Compounds Quinoline Aromatics Intermediates & Fine Chemicals Pharmaceuticals Heterocycles