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7-Hydroxyquinolinone

7-Hydroxyquinolinone structure

CAS No.: 70500-72-0

Chemical Name:: 7-Hydroxyquinolinone

Synonyms: 7-Hydroxyquinolin-2(1H)-one;quinoline-2,7-diol;2,7-DIHYDROXYQUINOLINE;7-Hydroxy-;7-hydroxyquinolinone;7-Hydroxycarbostyril;7-hydroxy-2(1H)-Quino;7- hydroxy-2-quinolone;7-HYDROXY-2-QUINOLINONE;N1-(2,3-dichlorophenyl)-N2

CBNumber:: CB6404930

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MDL Number:: MFCD04117979

MOL File:: 70500-72-0.mol

Last updated:2025-09-17 14:35:14

Product description	Number	Pack Size	Price
7-Hydroxyquinoline-(1H)-2-one	H953255	10g	$365
2,7-DIHYDROXYQUINOLINE 95.00%	CHM0966005	5MG	$495.78
7-Hydroxyquinolinone 95%	144291	5g	$903
7-Hydroxyquinolinone 95%	144291	25g	$2709
2,7-Dihydroxyquinoline 95+%	072934	1g	$12
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7-Hydroxyquinolinone Properties

Melting point	187-192°C
Boiling point	426.8±45.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	9.32±0.20(Predicted)
color	Off-White to Pale Yellow
Water Solubility	Water: Insoluble
InChI	InChI=1S/C9H7NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1-5,11H,(H,10,12)
InChIKey	DBSPUDKBNOZFMX-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC(O)=C2)C=CC1=O
CAS DataBase Reference	70500-72-0(CAS DataBase Reference)
FDA UNII	3B25C3NP9L
UNSPSC Code	41116107

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
HS Code	29334900

7-Hydroxyquinolinone price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	H953255	7-Hydroxyquinoline-(1H)-2-one	70500-72-0	10g	$365	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0966005	2,7-DIHYDROXYQUINOLINE 95.00%	70500-72-0	5MG	$495.78	2021-12-16	Buy
Matrix Scientific	144291	7-Hydroxyquinolinone 95%	70500-72-0	5g	$903	2021-12-16	Buy
Matrix Scientific	144291	7-Hydroxyquinolinone 95%	70500-72-0	25g	$2709	2021-12-16	Buy
Matrix Scientific	072934	2,7-Dihydroxyquinoline 95+%	70500-72-0	1g	$12	2021-12-16	Buy

Product number	Packaging	Price	Buy
H953255	10g	$365	Buy
CHM0966005	5MG	$495.78	Buy
144291	5g	$903	Buy
144291	25g	$2709	Buy
072934	1g	$12	Buy

7-Hydroxyquinolinone Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

7-Hydroxyquinolone is a substituted carbostyril derivative used as a pharmaceutical intermediate. It is an impurity of aripiprazole quinolinone.

Definition

ChEBI: 7-hydroxyquinolin-2(1H)-one is a monohydroxyquinoline and a quinolone.

Synthesis

127033-74-3

70500-72-0

General procedure for the synthesis of 7-hydroxyquinolin-2(1H)-one from N-(3-methoxyphenyl)cinnamamide: Aluminum trichloride (3.16 g, 23.69 mmol) was added batchwise to a suspension of chlorobenzene (30 mL) of compound 3 (1 g, 3.95 mmol) in an ice bath. The reaction mixture was gradually warmed up to 120 °C and kept at reflux for 3 hours. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure and the residue was purified by silica gel column chromatography to afford compound 4 in 54% yield.

References

[1] Synthesis, 1997, # 1, p. 87 - 90
[2] Tetrahedron Letters, 1999, vol. 40, # 24, p. 4505 - 4506
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 14, p. 5561 - 5578
[4] Patent: CN108101926, 2018, A. Location in patent: Paragraph 0033; 0034; 0035
[5] Patent: WO2008/24481, 2008, A2. Location in patent: Page/Page column 32

7-Hydroxyquinolinone synthesis

Synthesis of 7-Hydroxyquinolinone from 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone

7-Hydroxyquinolinone Preparation Products And Raw materials

Raw materials

N-(CINNAMOYL)-3-METHOXYANILINE (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Aluminum chloride Chlorobenzene

Preparation Products

DEHYDRO ARIPIPRAZOLE

7-Hydroxyquinolinone Suppliers

Global( 478)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD	+8613572219112	info@pushanshiye.com	China	165	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12248	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20183	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13355	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55

Supplier	Advantage
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from 7-Hydroxyquinolinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	7-Hydroxyquinolinone 70500-72-0	US $35.00-0.90 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-09-17	7-Hydroxycarbostyril 70500-72-0	US $0.00 / removed		97.54%	10g	TargetMol Chemicals Inc.
2025-08-08	7-Hydroxyquinolinone 70500-72-0	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.

7-Hydroxyquinolinone
70500-72-0
US $35.00-0.90 / kg
99%
Henan Fengda Chemical Co., Ltd

7-Hydroxycarbostyril
70500-72-0
US $0.00 / removed
97.54%
TargetMol Chemicals Inc.

7-Hydroxyquinolinone
70500-72-0
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

7-Hydroxyquinolinone Spectrum

7-Hydroxyquinolinone(70500-72-0)¹HNMR

70500-72-0(7-Hydroxyquinolinone)Related Search:

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Ethoxyquin Isoquinoline 8-Hydroxyquinoline Brexpiprazole 8-(2,3-Dichlorophenyl)-8-aza-5-azoniaspiro[4.5]decane BroMide

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Brexpiprazole Impurity 20 Thianaphthene

Brexpiprazole Impurity Brexpiprazole Impurity 2 Brexpiprazole sulfoxide impurity

1of4

2,7-DIHYDROXYQUINOLINE 7-HYDROXYQUINOLINE-(1H)-2-ONE 3,4-Dihydro-7-hydroxyquinoline-2(1H)-one 7-Hydroxyquinolin-2(1H)-one 3,4-DIHYDRO-7-HYDROXY-2(1H)-QUINOLINE 7-Hydroxycarbostyril 7-HYDROXY-2-QUINOLINONE 7-HYDROXY-1H-QUINOLIN-2-ONE 7-hydroxy-2-(1h)-quinolinone 7-HYDROXYQUINOLINE-2(1H)-ONE 7-hydroxyquinolinone 2(1H)-Quinolinone, 7-hydroxy- quinoline-2,7-diol 7-Hydroxy- 7-hydroxy-1,2-dihydroquinolin-2-one N1-(2,3-dichlorophenyl)-N2 4-Dihydro-7-hydroxycarbostyril 7- hydroxy-2-quinolone 7-hydroxy-2(1H)-Quino 7-Hydroxyquinolinone ISO 9001：2015 REACH Aripiprazole impurities1777 Aripiprazole Quinolinone ImpurityQ: What is Aripiprazole Quinolinone Impurity Q: What is the CAS Number of Aripiprazole Quinolinone Impurity Q: What is the storage condition of Aripiprazole Quinolinone Impurity Q: What are the applications of Aripiprazole Quinolinone Impurity Aripiprazole Quinolinone Impurity 7-Hydroxyquinoline-(1H)-2-one , 7-Hydroxy-2(1H)-quinolinone Brexpiprazole Dimer Impurity 6 7-Hydroxycarbostyril, 10 mM in DMSO 7-Hydroxy-2(1H)-quinolinone Aripiprazole Hydroxyquinolinone Analog 70500-72-0 142858-02-5 Aromatics Compounds Quinoline Aromatics Intermediates & Fine Chemicals Pharmaceuticals Heterocycles