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Boc-4-aminobenzylalcohol

Boc-4-aminobenzylalcohol Structure
Boc-4-aminobenzylalcohol structure
CAS No.
144072-29-7
Chemical Name:
Boc-4-aminobenzylalcohol
Synonyms
Boc-4-aminobenzylalcohol;4-(Boc-aMino)benzyl alcohol;tert-Butyl (4-(hydroxymethyl);TERT-BUTYL 4-(HYDROXYMETHYL)PHENYLCARBAMATE;4-benzyl alcohol;tert-butyl N-[4-(hydroxyMethyl)phenyl]carbaMate;CarbaMic acid N-[4-(hydroxyMethyl)phenyl]-1,1-diMethyl ester;Carbamic acid, N-[4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester
CBNumber:
CB5334423
Molecular Formula:
C12H17NO3
Molecular Weight:
223.27
MDL Number:
MFCD04974271
MOL File:
144072-29-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:29
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Boc-4-aminobenzylalcohol Properties

Melting point 74-76 °C
Boiling point 310.0±25.0 °C(Predicted)
Density 1.161±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 13.66±0.70(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2924297099

Boc-4-aminobenzylalcohol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR962629 4-(Boc-amino)benzyl alcohol 97% 144072-29-7 5g $21 2026-06-04 Buy
Apolloscientific OR962629 4-(Boc-amino)benzyl alcohol 97% 144072-29-7 25g $55 2026-06-04 Buy
Apolloscientific OR962629 4-(Boc-amino)benzyl alcohol 97% 144072-29-7 100g $164 2026-06-04 Buy
Apolloscientific OR962629 4-(Boc-amino)benzyl alcohol 97% 144072-29-7 500g $750 2026-06-04 Buy
Activate Scientific AS26332 4-(Boc-amino)benzyl alcohol 97% 144072-29-7 5g $30 2026-06-04 Buy
Product number Packaging Price Buy
OR962629 5g $21 Buy
OR962629 25g $55 Buy
OR962629 100g $164 Buy
OR962629 500g $750 Buy
AS26332 5g $30 Buy

Boc-4-aminobenzylalcohol Chemical Properties, Uses, Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

4-Aminobenzyl alcohol

623-04-1

BOC-4-AMINOBENZYLALCOHOL

144072-29-7

General procedure: p-Aminobenzyl alcohol (1 g, 8.12 mmol, 1 eq.) was dissolved in 80 mL of anhydrous tetrahydrofuran (THF) under nitrogen protection. To this solution was sequentially added N,N-diisopropylethylamine (DIEA, 1.4 mL, 8.12 mmol, 1 eq.) and di-tert-butyl dicarbonate (Boc2O, 1.9 mL, 8.12 mmol, 1 eq.). The reaction mixture was heated to reflux and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure in a rotary evaporator to remove the solvent. The residue was dissolved in ethyl acetate (EtOAc) and the organic layer was washed with 0.1 N hydrochloric acid solution to remove unreacted amine and DIEA.The organic layer was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated again under reduced pressure. The crude product was purified by silica gel column chromatography with petroleum ether-ethyl acetate (1:1, v/v) as eluent to afford BOC-4-aminobenzyl alcohol (1.85 g, quantitative yield). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (CDCl3) δ 1.49 (s, 9H), 2.17 (s, 1H), 4.53 (s, 2H), 6.83 (s, 1H), 7.19 (d, J = 8.5 Hz, 2H), 7.28 (d, J = 8.2 Hz, 2H); 13C NMR (CDCl3) δ 28.28, 64.54, 80.37, 118.49, 127.59, 135.31, 137.46, 152.72.

References

[1] Patent: WO2008/34124, 2008, A2. Location in patent: Page/Page column 72-73
[2] Patent: WO2006/31806, 2006, A2. Location in patent: Page/Page column 99
[3] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1355 - 1363
[4] Tetrahedron Letters, 2007, vol. 48, # 51, p. 9044 - 9047
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 22, p. 4150 - 4159

Boc-4-aminobenzylalcohol synthesis

24424-99-5
623-04-1
144072-29-7
Synthesis of Boc-4-aminobenzylalcohol from Di-tert-butyl dicarbonate and 4-Aminobenzyl alcohol

Boc-4-aminobenzylalcohol Preparation Products And Raw materials

Raw materials

Ethyl 4-(tert-butoxycarbonylamino)benzoate 4-Aminobenzyl alcohol (4-Formyl-phenyl)-carbamic acid tert-butyl ester Boc-4-abz-OH Di-tert-butyl dicarbonate
N,N-Diisopropylethylamine Tetrahydrofuran 4-Aminobenzoic acid Carbonic acid, bis(1,1-dimethylethyl) ester Benzocaine

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Preparation Products

Boc-4-aminobenzylalcohol Suppliers

Global Suppliers ( 91)
Supplier Tel Email Country ProdList Advantage
Heze Chuangfa Biotechnology Co., Ltd. 15864743015 15864743015 1187939516@qq.com China 144 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1997 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9336 55
Supplier Advantage
Heze Chuangfa Biotechnology Co., Ltd. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai yirong biology science and technology co., ltd 60
Chengdu Forest Science and Technology Development Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55

View Latest Price from Boc-4-aminobenzylalcohol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BOC-4-AMINOBENZYLALCOHOL pictures 2026-08-25 BOC-4-AMINOBENZYLALCOHOL
144072-29-7
 $75.00-750.00 1KG 0.99 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
BOC-4-AMINOBENZYLALCOHOL pictures 2026-07-13 BOC-4-AMINOBENZYLALCOHOL
144072-29-7
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
BOC-4-AMINOBENZYLALCOHOL pictures 2019-12-31 BOC-4-AMINOBENZYLALCOHOL
144072-29-7
 $1.00 1KG 99% 100KG Career Henan Chemical Co

Boc-4-aminobenzylalcohol Spectrum

BOC-4-AMINOBENZYLALCOHOL(144072-29-7)1HNMR

144072-29-7 (Boc-4-aminobenzylalcohol) Related Search:

Boc-4-abz-OH 6-(Boc-amino)-1-hydroxy-2,1-benzoxaborolane 3-Amino-4-tert-butoxycarbonylamino-benzoic acid methyl ester tert-Butyl 4-(methoxycarbonyl)-3-methoxyphenylcarbamate Boc-4-abz-OSu
3-Amino-4-tert-butoxycarbonylamino-benzoic acid Boc-4-aminobenzylalcohol Di-Boc-3,4-diaminobenzoic acid N-Boc-4-(methylamino)benzoic acid Boc-4-amino-3-methoxybenzoic acid
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TERT-BUTYL 4-(HYDROXYMETHYL)PHENYLCARBAMATE CarbaMic acid N-[4-(hydroxyMethyl)phenyl]-1,1-diMethyl ester 4-(Boc-aMino)benzyl alcohol tert-butyl N-[4-(hydroxyMethyl)phenyl]carbaMate tert-Butyl (4-(hydroxymethyl) 4-benzyl alcohol Carbamic acid, N-[4-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester Boc-4-aminobenzylalcohol 144072-29-7 CMLLYL