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Boc-4-abz-OH

Boc-4-abz-OH Structure
Boc-4-abz-OH structure
CAS No.
66493-39-8
Chemical Name:
Boc-4-abz-OH
Synonyms
4-(BOC-AMINO)BENZOIC ACID;BOC-PABA;AKOS 90574;Boc-PABA-OH;BOC-P-ABZ-OH;Boc-4-abz-OH;RARECHEM EM WB 0012;N-Boc-4-aminobenzoic;BOC-4-ABZ-OH USP/EP/BP;BOC-4-AMINOBENZOIC ACID
CBNumber:
CB3291568
Molecular Formula:
C12H15NO4
Molecular Weight:
237.25
MDL Number:
MFCD00037428
MOL File:
66493-39-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:58
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Boc-4-abz-OH Properties

Melting point ~200 °C (dec.)
Boiling point 336.2±25.0 °C(Predicted)
Density 1.242±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility soluble in Methanol
pka 4.33±0.10(Predicted)
form Powder
color Beige
BRN 2115614
Major Application peptide synthesis
InChI 1S/C12H15NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h4-7H,1-3H3,(H,13,16)(H,14,15)
InChIKey ZJDBQMWMDZEONW-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)Nc1ccc(cc1)C(O)=O
UNSPSC Code 12352209

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29242990
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

Boc-4-abz-OH price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 15299 Boc-4-Abz-OH ≥98.0% (T) 66493-39-8 5g $106 2023-01-07 Buy
Sigma-Aldrich 15299 Boc-4-Abz-OH ≥98.0% (T) 66493-39-8 50g $732 2023-01-07 Buy
TCI Chemical B3898 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) 66493-39-8 5g $31 2026-04-30 Buy
TCI Chemical B3898 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) 66493-39-8 25g $100 2026-04-30 Buy
Usbiological 264722 Boc-4-aminobenzoic acid Asreported 66493-39-8 10g $343 2026-06-03 Buy
Product number Packaging Price Buy
15299 5g $106 Buy
15299 50g $732 Buy
B3898 5g $31 Buy
B3898 25g $100 Buy
264722 10g $343 Buy

Boc-4-abz-OH Chemical Properties, Uses, Production

Chemical Properties

Light brown powder

Uses

4-(N-tert-Butoxycarbonyl)aminobenzoic Acid is the tert-Butyloxycarbonyl group protected derivative of 4-Aminobenzoic Acid (A591500), an widely distributed B complex factor in nature.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

4-Aminobenzoic acid

150-13-0

BOC-4-ABZ-OH

66493-39-8

General procedure for the synthesis of 4-(N-tert-butoxycarbonylamino)benzoic acid from di-tert-butyl dicarbonate and p-aminobenzoic acid: sodium hydroxide (1.46 g, 36.5 mmol) was added to a mixture of dioxane (70 mL) and water (35 mL) of 4-aminobenzoic acid (5.00 g, 36.5 mmol), followed by di-tert-butyl dicarbonate (11.9 g, 54.8 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and aqueous 3N hydrochloric acid was added slowly and dropwise to the residue to adjust the pH to 3. The precipitate precipitated was collected by filtration, washed with water and dried to afford the target product 4-(N-tert-butoxycarbonylamino)benzoic acid (8.28 g, 96% yield) as a white solid.

References

[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 3, p. 441 - 452
[2] Journal of Catalysis, 2016, vol. 340, p. 344 - 353
[3] Tetrahedron Letters, 2003, vol. 44, # 37, p. 7103 - 7106
[4] Synthesis, 2005, # 7, p. 1061 - 1068
[5] Chemistry - A European Journal, 2003, vol. 9, # 2, p. 557 - 560

Boc-4-abz-OH synthesis

110969-44-3
66493-39-8
Synthesis of Boc-4-abz-OH from Ethyl 4-(tert-butoxycarbonylamino)benzoate

Boc-4-abz-OH Preparation Products And Raw materials

Raw materials

Ethyl 4-(tert-butoxycarbonylamino)benzoate SilaCO - (Methyl(diphenyl)silyl)formic acid 4-(1-Hydroxy-ethyl)-benzoic acid methyl 4-(tert-butoxycarbonylamino)benzoate 4-Azidobenzoic acid
tert-Butyl N-(4-iodophenyl)carbamate tert-Butyl N-(4-bromophenyl)-carbamate 4-(phenylmethoxycarbonylamino)benzoic acid tert-Butyl formate carbon monoxide
Carbon dioxide Di-tert-butyl dicarbonate

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Preparation Products

Boc-4-aminobenzylalcohol

Boc-4-abz-OH Suppliers

Global Suppliers ( 200)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from Boc-4-abz-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BOC-4-ABZ-OH pictures 2019-12-20 BOC-4-ABZ-OH
66493-39-8
 $1.00 1KG 99% Career Henan Chemical Co

Boc-4-abz-OH Spectrum

BOC-4-ABZ-OH(66493-39-8)1HNMR

66493-39-8 (Boc-4-abz-OH) Related Search:

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4-Amino-3-(Fmoc-aminomethyl)-benzoic acid 2,3-Dimethyl-3,4-dihydro-2H-quinoxaline-1,6-dicarboxylic acid 1-tert-butyl ester BUTTPARK 120\07-94

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N-ALPHA-T-BUTOXYCARBONYL-4-AMINO-BENZOIC ACID N-ALPHA-T-BUTOXYCARBONYL-P-AMINOBENZOIC ACID N-BOC-4-AMINOBENZOIC ACID Boc-4-aminobenzoic acid98+% (Tert-Butoxy)Carbonyl 4-Abz-OH RARECHEM EM WB 0012 N-Boc-4-aminobenzoic Boc-4-Abz-OH(Boc-4-aMinobenzoic Acid) Boc-PABA-OH n-tert-butoxycarbonyl-4-aminobenzoic acid 4-(T-BUTYLOXYCARBONYLAMINO)-BENZOIC ACID 4-(TERT-BUTYLOXYCARBONYLAMINO)-BENZOIC ACID 4-TERT-BUTOXYCARBONYLAMINO-BENZOIC ACID BOC-4-AMINOBENZOIC ACID BOC-P-AMINOBENZOIC ACID BOC-PABA BOC-P-ABZ-OH AKOS 90574 N-Boc-4-aminobenzoicacid,97% 4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid 4-(N-tert-Butoxycarbonyl)aMinobenzoic Acid Boc-4-Abz-OH >=98.0% (T) N-tert-butoxycarbonyl-para-aminobenzoic acid 4-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-cyclohexanecarboxylate 4-(tert-Butoxycarbonylamino)benzoic Acid > Benzoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]- 4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoicaci BOC-4-ABZ-OH USP/EP/BP 4-(BOC-AMINO)BENZOIC ACID Boc-4-abz-OH 66493-39-8 CH33CO2CNHC6H4CO2H CARBOXYLIC ACID Peptide Synthesis Unnatural Amino Acid Derivatives Specialty Synthesis Aromatic Amino Acids Benzene series Amino Acids