BOC-4-ABZ-OH
- CAS No.
- 66493-39-8
- Chemical Name:
- BOC-4-ABZ-OH
- Synonyms
- 4-(BOC-AMINO)BENZOIC ACID;BOC-PABA;AKOS 90574;Boc-PABA-OH;BOC-4-ABZ-OH;BOC-P-ABZ-OH;RARECHEM EM WB 0012;N-Boc-4-aminobenzoic;BOC-4-ABZ-OH USP/EP/BP;BOC-4-AMINOBENZOIC ACID
- CBNumber:
- CB3291568
- Molecular Formula:
- C12H15NO4
- Molecular Weight:
- 237.25
- MDL Number:
- MFCD00037428
- MOL File:
- 66493-39-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-4-Abz-OH ≥98.0% (T) | 15299 | 5g | $106 |
| Boc-4-Abz-OH ≥98.0% (T) | 15299 | 50g | $732 |
| 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) | B3898 | 5g | $31 |
| 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) | B3898 | 25g | $100 |
| Boc-4-aminobenzoic acid Asreported | 264722 | 10g | $343 |
| More product size | |||
| Melting point | ~200 °C (dec.) |
|---|---|
| Boiling point | 336.2±25.0 °C(Predicted) |
| Density | 1.242±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | soluble in Methanol |
| pka | 4.33±0.10(Predicted) |
| form | Powder |
| color | Beige |
| BRN | 2115614 |
| Major Application | peptide synthesis |
| InChI | 1S/C12H15NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h4-7H,1-3H3,(H,13,16)(H,14,15) |
| InChIKey | ZJDBQMWMDZEONW-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)Nc1ccc(cc1)C(O)=O |
| UNSPSC Code | 12352209 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
BOC-4-ABZ-OH price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15299 | Boc-4-Abz-OH ≥98.0% (T) | 66493-39-8 | 5g | $106 | 2023-01-07 | Buy |
| Sigma-Aldrich | 15299 | Boc-4-Abz-OH ≥98.0% (T) | 66493-39-8 | 50g | $732 | 2023-01-07 | Buy |
| TCI Chemical | B3898 | 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) | 66493-39-8 | 5g | $31 | 2026-04-30 | Buy |
| TCI Chemical | B3898 | 4-(tert-Butoxycarbonylamino)benzoic Acid >98.0%(HPLC)(T) | 66493-39-8 | 25g | $100 | 2026-04-30 | Buy |
| Usbiological | 264722 | Boc-4-aminobenzoic acid Asreported | 66493-39-8 | 10g | $343 | 2026-06-03 | Buy |
BOC-4-ABZ-OH Chemical Properties,Uses,Production
Chemical Properties
Light brown powder
Uses
4-(N-tert-Butoxycarbonyl)aminobenzoic Acid is the tert-Butyloxycarbonyl group protected derivative of 4-Aminobenzoic Acid (A591500), an widely distributed B complex factor in nature.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
150-13-0
66493-39-8
General procedure for the synthesis of 4-(N-tert-butoxycarbonylamino)benzoic acid from di-tert-butyl dicarbonate and p-aminobenzoic acid: sodium hydroxide (1.46 g, 36.5 mmol) was added to a mixture of dioxane (70 mL) and water (35 mL) of 4-aminobenzoic acid (5.00 g, 36.5 mmol), followed by di-tert-butyl dicarbonate (11.9 g, 54.8 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and aqueous 3N hydrochloric acid was added slowly and dropwise to the residue to adjust the pH to 3. The precipitate precipitated was collected by filtration, washed with water and dried to afford the target product 4-(N-tert-butoxycarbonylamino)benzoic acid (8.28 g, 96% yield) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 3, p. 441 - 452
[2] Journal of Catalysis, 2016, vol. 340, p. 344 - 353
[3] Tetrahedron Letters, 2003, vol. 44, # 37, p. 7103 - 7106
[4] Synthesis, 2005, # 7, p. 1061 - 1068
[5] Chemistry - A European Journal, 2003, vol. 9, # 2, p. 557 - 560
BOC-4-ABZ-OH Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20582 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9539 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9796 | 58 |
View Lastest Price from BOC-4-ABZ-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-20 | BOC-4-ABZ-OH
66493-39-8
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- BOC-4-ABZ-OH
66493-39-8
- $1.00
- 99%
- Career Henan Chemical Co
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