3-Methylamino-1,2-propanediol
- CAS No.
- 40137-22-2
- Chemical Name:
- 3-Methylamino-1,2-propanediol
- Synonyms
- 3-Methylamino-1,2-Propandiol;3-METHYLAMINO-1,2-PROPANEDIOL;3-METHYLAMINO-PROPANE-1,2-DIOL;3-(methylamino)propane-1,2-dio;3-(AMINOMETHYL)-1,2-PROPANEDIOL;N-METHYL-3-AMINO-1,2-PROPANEDIOL;3-Methylamino-1,2-propanediol>1,2-Propanediol, 3-(methylamino)-;N-Methyl-2,3-dihydroxypropylamine;2,3-Dihydroxy-N-methylpropylamine
- CBNumber:
- CB9174021
- Molecular Formula:
- C4H11NO2
- Molecular Weight:
- 105.14
- MDL Number:
- MFCD00082732
- MOL File:
- 40137-22-2.mol
| Product description | Number | Pack Size | Price |
| 3-Methylamino-1,2-propanediol >98.0%(GC)(T) | M1243 | 25g | $51 |
| 3-Methylamino-1,2-propanediol | M332493 | 5g | $60 |
| 3-(Methylamino)propane-1,2-diol 98% | 091200 | 5g | $61 |
| 3-(Methylamino)propane-1,2-diol 98% | 091200 | 10g | $84 |
| 3-Methylamino-1,2-propanediol | V0533 | 25g | $49 |
| More product size | |||
| Melting point | 69°C (estimate) |
|---|---|
| Boiling point | 247 °C |
| Density | 1.095 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 152 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 14.09±0.20(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.0921 |
| PH | 11.5 (100g/l, H2O, 20℃) |
| Water Solubility | miscible |
| BRN | 1733341 |
| InChI | InChI=1S/C4H11NO2/c1-5-2-4(7)3-6/h4-7H,2-3H2,1H3 |
| InChIKey | WOMTYMDHLQTCHY-UHFFFAOYSA-N |
| SMILES | C(O)C(O)CNC |
| CAS DataBase Reference | 40137-22-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H314-H318 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P260h-P301+P330+P331-P303+P361+P353-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | 2735 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-34 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29221980 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Methylamino-1,2-propanediol price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M1243 | 3-Methylamino-1,2-propanediol >98.0%(GC)(T) | 40137-22-2 | 25g | $51 | 2025-07-31 | Buy |
| TRC | M332493 | 3-Methylamino-1,2-propanediol | 40137-22-2 | 5g | $60 | 2021-12-16 | Buy |
| Matrix Scientific | 091200 | 3-(Methylamino)propane-1,2-diol 98% | 40137-22-2 | 5g | $61 | 2021-12-16 | Buy |
| Matrix Scientific | 091200 | 3-(Methylamino)propane-1,2-diol 98% | 40137-22-2 | 10g | $84 | 2021-12-16 | Buy |
| AK Scientific | V0533 | 3-Methylamino-1,2-propanediol | 40137-22-2 | 25g | $49 | 2021-12-16 | Buy |
3-Methylamino-1,2-propanediol Chemical Properties,Uses,Production
Description
3-Methylamino-1,2-propanediol (MAPD) is a clear liquid with the chemical formula C4H11NO2. It can be synthesized from allylamine and alkanolamine via a thermal process. It reacts with chloride to form methyl chloroacetate, which can then be converted into 3-methylamino-1,2-propanediol by reaction with methanol. The production process for this substance has been shown to generate low levels of hazardous substances such as polycyclic aromatic hydrocarbons (PAHs) and dioxins.
Chemical Properties
clear colorless to pale yellow viscous liquid
Uses
3-Methylamino-1,2-propanediol is a reactive compound that is used in the synthesis of organic acids. It is also used as an intermediate in the manufacture of polyethylene glycols and particle coatings.
Definition
ChEBI: 3-methylamino-1,2-propanediol is a secondary amine.
Preparation
3-Methylamino-1,2-propanediol (MAPD) is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with
monomethyl amine in alkaline environment by adding sodium hydroxide.
Afterwards, the product undergoes a series of purification steps. 
N-Methyl-1-amino-2,3-propandiol (45A) Methylamine (172ml of a 40% solution in water, 2 mol) was cooled to 0 °C and 2,3-epoxy-1-propanol (25g, 0.34mol) was added at a rate to maintain the temperature at or below 10 °C. The mixture was stirred for 3 hours at 0 °C. Excess methylamine and water was evaporated in vacuo and the product was purified by distillation at 103-105 °C, at 0.5 mm Hg, to give the compound 3-Methylamino-1,2-propanediol.
Hazard
3-Methylamino-1,2-propanediol is danger.
H314 (32.76%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (67.24%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (65.52%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Synthesis
556-52-5
74-89-5
40137-22-2
II, Synthesis of 3-methylamino-1,2-propanediol (1) Pressure test: the reactor is subjected to pressure test to ensure that all test indexes are qualified before use. (2) feeding: start the hydraulic vacuum pump, vacuum the autoclave to 0.03MPa, then add the raw material into the high-pressure reactor according to the ratio of glycerol and liquid monomethylamine molar ratio of 1:10. (3) Reaction conditions: the temperature of the amination reactor was raised to 50℃±5℃, the pressure was maintained at 4.1-4.2MPa, and the reaction lasted 40 minutes. (4) Monomethylamine recovery: After the reaction is completed, monomethylamine is recovered by vacuum at 0.080 MPa, and the monomethylamine recovery device is utilized to recover the monomethylamine to the storage tank for reuse. (5) Distillation and purification: (1) Primary distillation: cool the autoclave to below 30℃, transfer the reaction mixture to the distillation kettle. Start the water jet vacuum pump, pass steam heating to the jacket of the distillation kettle, control the vacuum in the kettle to 0.06~0.07MPa. When the condensate starts to flow out, switch to the high-vacuum root-water ring unit, adjust the vacuum of the receiving tank to 0.0990~0.0998MPa, and monitor the temperature of the gas phase to 98.0℃ in order to remove the pre-fraction. (2) Main fraction collection: when the distillation temperature exceeds 98.1°C, switch to the finished product condensate tank, keep the vacuum degree to 0.0990~0.0998MPa, collect the fraction with condensing vapor temperature of 98.1-101.0°C, which is the target product of 3-methylamino-1,2-propanediol. The product was a colorless transparent viscous liquid with 98.99% yield, 99.96% purity, 0.04% impurity content and 0.35% moisture content.
References
[1] Patent: CN104844463, 2016, B. Location in patent: Paragraph 0186-0200
[2] Patent: EP1201644, 2002, A2. Location in patent: Page 17-20
[3] Chemische Berichte, 1899, vol. 32, p. 752
3-Methylamino-1,2-propanediol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20183 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 883 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10240 | 58 |
View Lastest Price from 3-Methylamino-1,2-propanediol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-13 | 3-Methylamino-1,2-propanediol
40137-22-2
|
US $0.00 / KG | 1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2025-09-25 | 3-Methylamino-1,2-propanediol
40137-22-2
|
US $32.00-1.50 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-09-23 | 3-Methylamino-1,2-propanediol
40137-22-2
|
US $0.00-0.00 / KG | 1KG | 99% | 20000 | Shenzhen Nexcon Pharmatechs Ltd. |
-
- 3-Methylamino-1,2-propanediol
40137-22-2
- US $0.00 / KG
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- 3-Methylamino-1,2-propanediol
40137-22-2
- US $32.00-1.50 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Methylamino-1,2-propanediol
40137-22-2
- US $0.00-0.00 / KG
- 99%
- Shenzhen Nexcon Pharmatechs Ltd.
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