ChemicalBook >> CAS DataBase List >>2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one structure

CAS No.: 106461-41-0

Chemical Name:: 2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one

Synonyms: Dhmt;2,4-DIHYDRO-4-[4-[4-(HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-2-(SEC-BUTYL)-3H-1,2,4-TRIAZOL-3-ONE;T 1330;2,4 Dihydro-4;5-LOX inhibitor;4-TRIAZOLE-3-ONE;Hydroxyl compound;Itraconazole Impurity 22;Itraconazole Hydroxy Isobutyltriazolone;piperazinyl]phenyl]-2-(1-methylpropyl)-

CBNumber:: CB5356302

Molecular Formula:: C22H27N5O2

Molecular Weight:: 393.48

MDL Number:: MFCD02093087

MOL File:: 106461-41-0.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:30

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2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one Properties

Melting point	177-179°C
Boiling point	587.9±60.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
pka	12.18±0.30(Predicted)
color	Off-White Pale Brown
InChI	InChI=1S/C22H27N5O2/c1-3-17(2)27-22(29)26(16-23-27)20-6-4-18(5-7-20)24-12-14-25(15-13-24)19-8-10-21(28)11-9-19/h4-11,16-17,28H,3,12-15H2,1-2H3
InChIKey	FFAQILVGBAELHN-UHFFFAOYSA-N
SMILES	N1=CN(C2=CC=C(N3CCN(C4=CC=C(O)C=C4)CC3)C=C2)C(=O)N1C(C)CC
CAS DataBase Reference	106461-41-0(CAS DataBase Reference)
FDA UNII	OBT4EGVAZU

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	D3570-90	2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one		50mg	$531	2026-06-03	Buy
TRC	TRC-D449140-50MG	2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one	106461-41-0	50mg	$259	2026-06-03	Buy
TRC	TRC-D449140-25MG	2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one	106461-41-0	25mg	$149	2026-06-03	Buy
TRC	TRC-D449140-100MG	2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one	106461-41-0	100mg	$445	2026-06-03	Buy
ChemScene	CS-0169055	T-1330 ≥98%	106461-41-0	10g	$60	2026-06-04	Buy

Product number	Packaging	Price	Buy
D3570-90	50mg	$531	Buy
TRC-D449140-50MG	50mg	$259	Buy
TRC-D449140-25MG	25mg	$149	Buy
TRC-D449140-100MG	100mg	$445	Buy
CS-0169055	10g	$60	Buy

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one Chemical Properties, Uses, Production

Chemical Properties

Light Grey Powder

Uses

An intermediate in the synthesis of Itraconazole.

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one synthesis

Synthesis of 2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one from 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one Preparation Products And Raw materials

Raw materials

Formaldehyde, [2-(1-methylpropyl)hydrazinyl]- Hydrazinecarboxaldehyde, 2-(1-methylpropylidene)- 4-([4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl)-carbamic acid phenyl ester 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

1-(4-Methoxyphenyl)-4-(4-nitrophenyl)piperazine 1-(4-Aminophenyl)-4-(4-methoxyphenyl)piperazine 1-(4-Methoxyphenyl)piperazine Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate 4-Chloronitrobenzene

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Preparation Products

Itraconazole

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one Suppliers

Global Suppliers ( 205)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhengzhou HongSheng Pharmaceutical Co., Ltd.	0371-0371-13526885213 15637198702	hsyykjchem@163.com	China	1855	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
shanghai science Bio-Pharmceutical.co,ltd.	021-021-57872719 13761402923	245662540@qq.com	China	299	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6744	52
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9336	55
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58

Supplier	Advantage
Zhengzhou HongSheng Pharmaceutical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
shanghai science Bio-Pharmceutical.co,ltd.	60
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Syntechem Co.,Ltd	57
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
TargetMol Chemicals Inc.	58

View Latest Price from 2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-04	5-LOX inhibitor 106461-41-0	$38.00-129.00		98.52%	10g	TargetMol Chemicals Inc.
2025-11-21	2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one 106461-41-0	$780.00	1g	99	5000 Kg	R&D Scientific Inc.
2020-02-12	2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 106461-41-0	$7.00	1KG	99%	100KG	Career Henan Chemical Co

5-LOX inhibitor
106461-41-0
$38.00-129.00
98.52%
TargetMol Chemicals Inc.

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one
106461-41-0
$780.00
99
R&D Scientific Inc.

2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE
106461-41-0
$7.00
99%
Career Henan Chemical Co

2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one Spectrum

2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE(106461-41-0)¹HNMR

106461-41-0 (2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one) Related Search:

2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3h-1,2,4-triazole-3-on trans-Itraconazole Itraconazole 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one (1,2,4-Triazol-4-yl) Itraconazole

Propyl Itraconazole Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine Butyl Itraconazole

Itraconazole Impurity 34 N-Desalkyl Itraconazole cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol Isopropyl Itraconazole DPUDRFOQNBKHMF-YZNIXAGQSA-N

Cis bromo benzoate Hydroxy itraconazole 1-(4-Aminophenyl)-4-(4-methoxyphenyl)piperazine

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Itraconazole Hydroxy Isobutyltriazolone IMpurity 1-(sec-butyl)-4-(2-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol- 2-sec-butyl-4-{4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl}-2h-1,2,4-triazol-3(4h)-one 2-butan-2-yl-4-[2-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-1,2,4-triazol-3-one 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl)Phenyl]-2-(1-Methyl Propyl)-3H-1,2,4-Triazole-3-One. Itraconazole Hydroxy Isobutyltriazolone 2,4-DIHYDRO-4-[(4-HYDROXYPHENYL)-1-PIPER AZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2 4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-3 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-3h-1,2,4-Triazol-3-One 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one(DHMT) 2,4-Dihydro-4[4-[4-(4-Hydroxyphenyl)-1-Piperazinyl]-Phenyl]-2-(1-Methylpropyl)-3H-1,Triazole-3-One 2,4-Dihydro-4-[4-[4-(4-Hydroxylphenyl)Piperazin-l-ylPhenyl-2-(l-Methylpropyl)-3H-1,2,4-Triazol-3-One 2,4-Dichloro-4-[[4-(4-hydroxyphenyl)-1-piperazinyl]-phen-yl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 2,4-Dihydro-4-{4-Hydroxyphenyl)-2-(1- Methyl Propyl)-3H-1,2,4-Triazole-3-One 2,4-dihydro-4-[4-[4-4-(hydroxyphenyl)-1- piperazinyl]phenyl]-2-(1-methylpropyl)- Dihydro hydroxyphenyl piperazinyl phenyl methylpropyl triazole one T 1330 2-SEC-BUTYL-4-[4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL]-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOL-3-ONE 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYPHENYL)-1-PIPERAZINYL]PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 1-SEC BUTYL-[4[4(4-HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-1,2,4-TRIAZOLO-5-ONE 4-[4-[4-[4-Hydroxyphenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one Itraconazole Impurity 22 2, 4 - dihydro - 4 - [[4 - (4 - hydroxy phenyl) - 1 - piperazine base] phenyl] - 2 - (1 - methyl propyl) - 3 h - 1, 4-trichlorobenzene three azole nitrogen - 3 - ketone 3H-1,2,4-Triazol-3-one, 2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)- 2,4-DIHYDRO-4-[4-[4-(4-HYDROXYLPHENYL)PIPERAZIN-1-YL]PHEN- ,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-hydroxylphenyl)piperazin-1-yl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 4-TRIAZOLE-3-ONE 4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1 2,4 Dihydro-4 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1-piperazinyl]-phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one (IT – VII)--S 4-[4-[4-(4-Hydroxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl]-1- piperazinyl]phenyl]-2-(1 methylpropyl)-3H-1,2,4- triazol-3-1 Hydroxyl compound 1-(sec-Butyl)-4-[2-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-1H-1,2,4-triazol-5(4H)-one 5-LOX inhibitor 4-[4-[4-(4-Hydroxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazo 2,4-Dihydro-4-[4-[4-(4-Hydroxyphenyl]-1-Piperazinyl]-Phenyl]-2-(1-Methylpropyl)-3H-1,2,4-Triazol-3-One [IT-7] 2,4-dihydro-4-[[4-(4-hydroxyphenyl)-1-azineyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazazole-3-one 2,4-DIHYDRO-4-[4-[4-(HYDROXYPHENYL)-1-PIPERAZINYL]-PHENYL]-2-(SEC-BUTYL)-3H-1,2,4-TRIAZOL-3-ONE Dhmt 2-Butan-2-yl-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-one 2,4-Dihydro-4-[(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazole-3-one 106461-41-0 C22H27N5O2 Intermediates & Fine Chemicals Pharmaceuticals