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HYDROXY ITRACONAZOLE

HYDROXY ITRACONAZOLE structure

CAS No.: 112559-91-8

Chemical Name:: HYDROXY ITRACONAZOLE

Synonyms: R 63373;HYDROXY ITRACONAZOLE;Itraconazole Impurity 1;2H6]-Hydroxyitraconazole;Ketoconazole Impurity 36;Itraconazole 2-Hydroxy Metabolite;Hydroxy Itraconazole (10mM in DMSO);Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole);Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole

CBNumber:: CB8173597

Molecular Formula:: C35H38Cl2N8O5

Molecular Weight:: 721.63

MDL Number:: MFCD28964104

MOL File:: 112559-91-8.mol

MSDS File:: SDS

Last updated:2026-01-21 16:49:52

Product description	Number	Pack Size	Price
Hydroxy Itraconazole ≥95% (mixture of diastereomers)	22576	500μg	$153
Hydroxy Itraconazole ≥95% (mixture of diastereomers)	22576	1mg	$275
Hydroxy Itraconazole	H9090-76	1mg	$460
HydroxyItraconazole	H943600	25mg	$2110
HydroxyItraconazole 99.60%	CS-4095	5mg	$1020
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HYDROXY ITRACONAZOLE Properties

Melting point	76-78°C
Boiling point	884.7±75.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	14.72±0.20(Predicted)
form	Solid
color	White to Pale Beige
Major Application	clinical testing
InChIKey	ISJVOEOJQLKSJU-UHFFFAOYSA-N
SMILES	Clc1c(ccc(c1)Cl)C3(OC(CO3)COc4ccc(cc4)N5CCN(CC5)c6ccc(cc6)N7C=NN(C7=O)C(C(O)C)C)C[n]2ncnc2
FDA UNII	0X2BAV045O
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

target organs

Eyes

WGK Germany

WGK 1

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1

NFPA 704

	0
2		0

HYDROXY ITRACONAZOLE price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22576	Hydroxy Itraconazole ≥95% (mixture of diastereomers)	112559-91-8	500μg	$153	2024-03-01	Buy
Cayman Chemical	22576	Hydroxy Itraconazole ≥95% (mixture of diastereomers)	112559-91-8	1mg	$275	2024-03-01	Buy
Usbiological	H9090-76	Hydroxy Itraconazole	112559-91-8	1mg	$460	2021-12-16	Buy
TRC	H943600	HydroxyItraconazole	112559-91-8	25mg	$2110	2021-12-16	Buy
ChemScene	CS-4095	HydroxyItraconazole 99.60%	112559-91-8	5mg	$1020	2021-12-16	Buy

Product number	Packaging	Price	Buy
22576	500μg	$153	Buy
22576	1mg	$275	Buy
H9090-76	1mg	$460	Buy
H943600	25mg	$2110	Buy
CS-4095	5mg	$1020	Buy

HYDROXY ITRACONAZOLE Chemical Properties,Uses,Production

Description

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

Chemical Properties

Off-White Crystalline Solid

Uses

A metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.

in vivo

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view^[1].

References

[1] Y MIKAMI. Comparison of in vitro antifungal activity of itraconazole and hydroxy-itraconazole by colorimetric MTT assay.[J]. Mycoses, 1994, 37 1-2: 27-33. DOI: 10.1111/j.1439-0507.1994.tb00281.x
[2] YASUAKI MINO . Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole[J]. Clinica Chimica Acta, 2013, 415: Pages 128-132. DOI: 10.1016/j.cca.2012.10.028

HYDROXY ITRACONAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

HYDROXY ITRACONAZOLE Suppliers

Global( 113)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39042	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	+undefined18603013401	jack.lin@sincopharmachem.com	China	9999	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
Biochempartner	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Career Henan Chemica Co	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76

View Lastest Price from HYDROXY ITRACONAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-01-21	Hydroxy Itraconazole 112559-91-8	US $278.00-993.00 / mg		99.59%	10g	TargetMol Chemicals Inc.

Hydroxy Itraconazole
112559-91-8
US $278.00-993.00 / mg
99.59%
TargetMol Chemicals Inc.

HYDROXY ITRACONAZOLE Spectrum

HYDROXY ITRACONAZOLE(112559-91-8)¹HNMR

112559-91-8(HYDROXY ITRACONAZOLE)Related Search:

Itraconazole 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE trans-Itraconazole

N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-

1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole Propyl Itraconazole (1,2,4-Triazol-4-yl) Itraconazole

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Itraconazole Impurity 15 cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate

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HYDROXY ITRACONAZOLE 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)- 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one R 63373 Itraconazole Impurity 8(Hydroxy Itraconazole) 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)- Itraconazole 2-Hydroxy Metabolite Itraconazole metabolite Hydroxy Itraconazole Itraconazole Impurity 1 Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one Hydroxy Itraconazole (10mM in DMSO) Hydroxy Itraconazole D8Q: What is Hydroxy Itraconazole D8 Q: What is the CAS Number of Hydroxy Itraconazole D8 Q: What is the storage condition of Hydroxy Itraconazole D8 Q: What are the applications of Hydroxy Itraconazole D8 Hydroxy ItraconazoleQ: What is Hydroxy Itraconazole Q: What is the CAS Number of Hydroxy Itraconazole Q: What is the storage condition of Hydroxy Itraconazole Q: What are the applications of Hydroxy Itraconazole 2H6]-Hydroxyitraconazole Ketoconazole Impurity 36 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(3-hydroxybutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one 112559-91-8 C35H40Cl2N8O4 C35H38Cl2N8O5 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Various Metabolites and Impurities Isotooe labelled metabolites metabolites Isotopically Labeled Pharmaceutical Reference Standard