ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate
- CAS No.
- 300803-69-4
- Chemical Name:
- ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate
- Synonyms
- STOML3 inhibitor OB-1;ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate;3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester
- CBNumber:
- CB53577722
- Molecular Formula:
- C21H17N3O6
- Molecular Weight:
- 407.38
- MDL Number:
- MFCD01462999
- MOL File:
- 300803-69-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | A solid |
| color | White to off-white |
| InChIKey | UJHGRDVYTTVJFD-UHFFFAOYSA-N |
| SMILES | [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37584 | STOML3 Inhibitor OB-1 ≥98% | 300803-69-4 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 37584 | STOML3 Inhibitor OB-1 ≥98% | 300803-69-4 | 10mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 37584 | STOML3 Inhibitor OB-1 ≥98% | 300803-69-4 | 25mg | $312 | 2026-04-30 | Buy |
| Biosynth | AMA80369 | Stoml3 inhibitor ob-1 | 300803-69-4 | 50mg | $1052.5 | 2026-06-04 | Buy |
| Biosynth | AMA80369 | Stoml3 inhibitor ob-1 | 300803-69-4 | 100mg | $1466 | 2026-06-04 | Buy |
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate Chemical Properties,Uses,Production
Uses
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin[1].
Biological Activity
OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.
in vivo
OB-1 (250-500 pmol per paw; s.c.; once) reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in mice[1].
OB-1 (250 pmol per paw; s.c.; once) alleviates painful diabetic neuropathy in mice[1].
| Animal Model: | C57Bl/6N mice[1] |
| Dosage: | 250-500 pmol per paw |
| Administration: | Subcutaneous injection, once |
| Result: | Over 40% of Aβ fibers (19/44) lacked a mechanosensitive receptive field, which was significantly different from that in vehicle-injected controls, where less than 7% (5/69 fibers) were found to be insensitive to mechanical stimuli. Reduced touch perception. Reversed tactile allodynia. |
| Animal Model: | Eight-week-old C57Bl/6 mice, Streptozotocin (HY-13753) model[1] |
| Dosage: | 250 pmol per paw |
| Administration: | Subcutaneous injection, once |
| Result: | Substantially reversed the mechanical hypersensitivity 4 h after treatment. |
storage
Store at RT
References
[1] Wetzel C, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat Neurosci. 2017 Feb;20(2):209-218. DOI:10.1038/nn.4454
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2223443625@qq.com | China | 7996 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 4572 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2936 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
View Lastest Price from ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate manufacturers
300803-69-4(ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate)Related Search:
1of2
