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ChemicalBook >> CAS DataBase List >>4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Structure
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID structure
CAS No.
39793-31-2
Chemical Name:
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
Synonyms
DAO-IN-2;79793-31-2;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor;Thieno[2,3-b]pyrrole-5-carboxylic acid;4-Thieno[3,2-b]pyrrole-5-carboxylic acid;4H-Thieno[3,2-b]pyrrol-5-carboxylic acid;4H-thieno[2,3-d]pyrrole-5-carboxylic acid;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid
CBNumber:
CB9349944
Molecular Formula:
C7H5NO2S
Molecular Weight:
167.19
MDL Number:
MFCD07368542
MOL File:
39793-31-2.mol
MSDS File:
SDS
Last updated:2026-05-28 05:29:22
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4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Properties

Melting point 180 °C
Boiling point 437.4±25.0 °C(Predicted)
Density 1.609
storage temp. Sealed in dry,2-8°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
form Beige solid
pka 4.36±0.30(Predicted)
color Light brown to gray
InChI InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
InChIKey PMHDSACGRKBACK-UHFFFAOYSA-N
SMILES N1C(C(O)=O)=CC2SC=CC1=2
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  22-26-36/37/39
WGK Germany  3
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 760250 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid 97% 39793-31-2 500mg $31.6 2023-06-20 Buy
Sigma-Aldrich 138000 D-Amino Acid Oxidase Inhibitor 39793-31-2 50mg $110 2023-01-07 Buy
Cayman Chemical 23894 D-Amino Acid Oxidase Inhibitor ≥98% 39793-31-2 50mg $28 2026-04-30 Buy
Cayman Chemical 23894 D-Amino Acid Oxidase Inhibitor ≥98% 39793-31-2 100mg $42 2026-04-30 Buy
Cayman Chemical 23894 D-Amino Acid Oxidase Inhibitor ≥98% 39793-31-2 250mg $97 2026-04-30 Buy
Product number Packaging Price Buy
760250 500mg $31.6 Buy
138000 50mg $110 Buy
23894 50mg $28 Buy
23894 100mg $42 Buy
23894 250mg $97 Buy

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

DAO-IN-2 is a novel D-amino acid oxidase (DAO) inhibitor. DAO-IN-2 demonstrates moderate potency for DAO in vitro and ex vivo[1].

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053

General Description

A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.

References

[1] Tim Sparey, et, al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008,18, 11. DOI:10.1016/j.bmcl.2008.04.020

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Suppliers

Global( 93)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Luohua Medical Technology Co.,Ltd. 13477084141; 13477084141 sales@luohuapharm.com China 468 60
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Record Tech (Shanghai) Co., LTD 13761627472 183009664@qq.com China 661 62
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Wuxi Zhangkun Biochemical Technology Co., Ltd. +86 0510-85629785 China 2321 58
Supplier Advantage
Wuhan Luohua Medical Technology Co.,Ltd. 60
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Ennopharm Co., Ltd. 65
Record Tech (Shanghai) Co., LTD 62
Hangzhou Sage Chemical Co., Ltd. 58
Thermo Fisher Scientific 75
9ding chemical ( Shanghai) Limited 55
Wuxi Zhangkun Biochemical Technology Co., Ltd. 58

View Lastest Price from 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID pictures 2019-07-06 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
39793-31-2
 $1.00 1kg 98% 200kg Career Henan Chemical Co

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Spectrum

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID(39793-31-2)1HNMR

39793-31-2(4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID)Related Search:

Thiazole-4-carboxamide Thiazole-5-carboxylic acid 4-Thiazolecarboxylic acid Ethyl thiazole-5-carboxylate Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate
4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID 6H-Thieno[2,3-b]pyrrole-5-carboxylic acid ethyl ester 3-Bromo-4(H)-thieno[3,2-b]pyrrole-5-carboxylicacid Methyl 4H-thieno[3,2-b!pyrrole-5-carboxylate, 97+% METHYL 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE
4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID,4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid 97% ETHYL 3-CHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID METHYL 4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 6H-Thieno[2,3-b]pyrrole-5-carboxylic acid
Ethyl 2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate Ethyl 2-chloro-3-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate Ethyl 3-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

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4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE) Thieno[2,3-b]pyrrole-5-carboxylic acid 4H-thieno[2,3-d]pyrrole-5-carboxylic acid D-Amino Acid Oxidase Inhibitor AKOS BB-9991 CHEMBRDG-BB 4012315 D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem 79793-31-2 4-Thieno[3,2-b]pyrrole-5-carboxylic acid 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid (6CI, 7CI, 9CI, ACI) DAO-IN-2 4H-Thieno[3,2-b]pyrrol-5-carboxylic acid 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid 39793-31-2 79793-31-2 C7H5NO2S