Methyl 3-(acetylamino)-2-thiophenecarboxylate
- CAS No.
- 22288-79-5
- Chemical Name:
- Methyl 3-(acetylamino)-2-thiophenecarboxylate
- Synonyms
- methyl 3-acetamidothiophene-2-carboxylate;Methyl 3-(acetylamino)-2-thiophenecarboxylate;3-AcetylaMino-thiophene-2-carboxylic acid Methyl ester;2-Thiophenecarboxylic acid, 3-(acetylamino)-, methyl ester
- CBNumber:
- CB5358412
- Molecular Formula:
- C8H9NO3S
- Molecular Weight:
- 199.23
- MDL Number:
- MFCD00100044
- MOL File:
- 22288-79-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| HazardClass | IRRITANT |
Methyl 3-(acetylamino)-2-thiophenecarboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 045025 | Methyl 3-(acetylamino)-2-thiophenecarboxylate | 22288-79-5 | 500.00mg | $181 | 2026-05-18 | Buy |
| Matrix Scientific | 045025 | Methyl 3-(acetylamino)-2-thiophenecarboxylate | 22288-79-5 | 1.00g | $228 | 2026-05-18 | Buy |
| Matrix Scientific | 045025 | Methyl 3-(acetylamino)-2-thiophenecarboxylate | 22288-79-5 | 5.00g | $524 | 2026-05-18 | Buy |
| Synthonix | M49346 | Methyl 3-acetamidothiophene-2-carboxylate 97% | 22288-79-5 | 100mg | $61 | 2026-05-06 | Buy |
| Synthonix | M49346 | Methyl 3-acetamidothiophene-2-carboxylate 97% | 22288-79-5 | 250mg | $67 | 2026-05-06 | Buy |
Methyl 3-(acetylamino)-2-thiophenecarboxylate Chemical Properties, Uses, Production
Synthesis
22288-78-4
75-36-5
22288-79-5
Methyl 3-amino-2-thiophenecarboxylate (3.14 g, 20.0 mmol) was dissolved in pyridine (20 mL) and acetyl chloride (1.5 mL, 21 mmol) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 3 hours, then cooled again in an ice bath and supplemented with acetyl chloride (0.3 mL, 4 mmol). Stirring was continued at room temperature for 1.5 h. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. The resulting solid product was suspended and washed with water to give the final methyl 3-acetylaminothiophene-2-carboxylate (3.80 g, 19.1 mmol, 96% yield).
References
[1] Patent: JP2018/95564, 2018, A. Location in patent: Paragraph 0097-0099
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 215 - 227
[3] Patent: US2008/4325, 2008, A1. Location in patent: Page/Page column 18
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 1, p. 9 - 12
Methyl 3-(acetylamino)-2-thiophenecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Accela ChemBio Co.,Ltd. | 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3995 | 55 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
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