3-Cyclopropyl-3-oxo-propionic acid ethyl ester
- CAS No.
- 24922-02-9
- Chemical Name:
- 3-Cyclopropyl-3-oxo-propionic acid ethyl ester
- Synonyms
- ETHYL 3-CYCLOPROPYL-3-OXO-PROPANOATE;Ethyl β-oxo-cyclopropanepropionate;Carbethoxymethyl cyclopropyl ketone;10Ethyl 3-cyclopropyl-3-oxopropanoate;Ethyl beta-oxo-Cyclopropane Propionate;β-Oxocyclopropanepropanoic athyl ester;3-Cyclopropyl-3-oxo-propionicethyl ester;Ethyl 3-cyclopropyl-3-oxopropionate, 97%;3-Cyclopropyl-3-oxopropionate ethyl ester;β-Oxocyclopropanepropanoic acid ethyl ester
- CBNumber:
- CB5360116
- Molecular Formula:
- C8H12O3
- Molecular Weight:
- 156.18
- MDL Number:
- MFCD00184570
- MOL File:
- 24922-02-9.mol
- MSDS File:
- SDS
| Boiling point | 73℃/1mm |
|---|---|
| Density | 1.058 g/mL at 25 °C |
| refractive index | n20/D1.449 |
| Flash point | >96℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 10.61±0.20(Predicted) |
| color | Colourless |
| InChI | InChI=1S/C8H12O3/c1-2-11-8(10)5-7(9)6-3-4-6/h6H,2-5H2,1H3 |
| InChIKey | LFSVADABIDBSBV-UHFFFAOYSA-N |
| SMILES | C1(CC1)C(=O)CC(=O)OCC |
| CAS DataBase Reference | 24922-02-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2918300090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
3-Cyclopropyl-3-oxo-propionic acid ethyl ester price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 722464 | Ethyl-3-cyclopropyl-3-oxopropionate 96% | 24922-02-9 | 1g | $28.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 722464 | Ethyl-3-cyclopropyl-3-oxopropionate 96% | 24922-02-9 | 5g | $28.5 | 2026-04-30 | Buy |
| TCI Chemical | E1023 | Ethyl 3-Cyclopropyl-3-oxopropanoate min. 97.0 % | 24922-02-9 | 5G | $23 | 2026-04-30 | Buy |
| TCI Chemical | E1023 | Ethyl 3-Cyclopropyl-3-oxopropanoate min. 97.0 % | 24922-02-9 | 25G | $61 | 2026-04-30 | Buy |
| TRC | TRC-E926328-50G | Ethyl 3-cyclopropyl-3-oxopropanoate | 24922-02-9 | 50g | $90 | 2026-06-03 | Buy |
3-Cyclopropyl-3-oxo-propionic acid ethyl ester Chemical Properties, Uses, Production
Uses
Ethyl 3-cyclopropyl-3-oxopropanoate
Synthesis
6148-64-7
4023-34-1
24922-02-9
Under cooling conditions in an ice bath, monoethyl malonate potassium salt (17.0 g, 0.10 mol) was suspended in ethyl acetate (100 ml) and triethylamine (34.7 ml, 0.25 mol) and magnesium chloride (14.3 g, 0.15 mol) were added sequentially. The resulting mixture was stirred and reacted at 40°C for 20 hours. Cyclopropanecarbonyl chloride (4.30 g, 50.0 mmol) was also taken and dissolved in tetrahydrofuran (50 ml), oxalyl chloride (4.36 ml, 50.0 mmol) and a catalytic amount of N,N-dimethylformamide were added under the cooling of an ice bath, stirred for 1 h. After stirring, it was moved to room temperature and the reaction was continued for 1 h. The reaction was continued at room temperature. Subsequently, the previously prepared malonic acid solution was slowly added to this chloride solution under ice bath cooling and the reaction was stirred at room temperature for 20 hours. After completion of the reaction, the mixture was poured into 10% aqueous citric acid solution (300 ml) and extracted with ethyl acetate (300 ml x 3). The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate (500 ml) and brine (300 ml) and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give ethyl 3-cyclopropyl-3-carbonyl-propionate 7.26 g (93% yield) as a colorless oil, which was used directly in the next reaction.1H-NMR (400 MHz, CDCl3) δ: 0.94-0.99 (2H, m), 1.10-1.15 (2H, m), 1.28 (3H, t, J=7.08 Hz). 2.01-2.06 (1H, m), 3.57 (2H, s), 4.21 (2H, q, J=7.08Hz).
References
[1] Patent: EP1479681, 2004, A1. Location in patent: Page 59
[2] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 31
3-Cyclopropyl-3-oxo-propionic acid ethyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Jiete Pharmaceutical Technology Co., Ltd | 0551-18256521115 18256521115 | 2788434637@qq.com | China | 32 | 58 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Shandong Zhongke Taidou Chemical Co., Ltd. | 0531-88682301 18595278760 | sdzkzf@sdzktd.com | China | 109 | 62 |
| Shanghai Yuben Technology Co., Ltd. | 13917011423 | 86908523@qq.com | China | 68 | 58 |
| Shandong Meiao Huawei Technology Co., LTD | 0531-88682301 18595278766 | yuhongmeng@mayowell.com | China | 88 | 58 |
| Shandong Laifu Technology Development Co., Ltd. | 13306419651 | 1375993372@qq.com | China | 57 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from 3-Cyclopropyl-3-oxo-propionic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9
|
1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
 |
2021-07-13 | 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-02-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-02-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9
- 98%
- Nanjing Fred Technology Co., Ltd
-
- 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-02-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-02-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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