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ChemicalBook >> CAS DataBase List >>1,5-Isoquinolinediol

1,5-Isoquinolinediol

1,5-Isoquinolinediol Structure
1,5-Isoquinolinediol structure
CAS No.
5154-02-9
Chemical Name:
1,5-Isoquinolinediol
Synonyms
DHQ;DIQ;NSC 65585;1,5-Isoquinolinediol;isoquinoline-1,5-diol;PARP Inhibitor IV, IQD;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-Isoquinolinediol ,97%
CBNumber:
CB5360303
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MDL Number:
MFCD00006900
MOL File:
5154-02-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:31
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1,5-Isoquinolinediol Properties

Melting point 270-275 °C
Boiling point 287.44°C (rough estimate)
Density 1.2480 (rough estimate)
refractive index 1.5050 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO: >36 mg/mL
form solid
pka 8.52±0.20(Predicted)
color off-white
InChI InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChIKey LFUJIPVWTMGYDG-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C(O)=CC=C2)C=CN1
CAS DataBase Reference 5154-02-9(CAS DataBase Reference)
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HS Code  29337900
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

1,5-Isoquinolinediol price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 419800 PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. 5154-02-9 5MG $96.4 2023-01-07 Buy
Sigma-Aldrich I138 1,5-Isoquinolinediol ≥98% (HPLC), powder 5154-02-9 5MG $59.9 2022-05-15 Buy
Cayman Chemical 14438 1,5-Isoquinolinediol ≥98% 5154-02-9 5mg $40 2026-04-30 Buy
Cayman Chemical 14438 1,5-Isoquinolinediol ≥98% 5154-02-9 25mg $86 2026-04-30 Buy
Cayman Chemical 14438 1,5-Isoquinolinediol ≥98% 5154-02-9 100mg $228 2026-04-30 Buy
Product number Packaging Price Buy
419800 5MG $96.4 Buy
I138 5MG $59.9 Buy
14438 5mg $40 Buy
14438 25mg $86 Buy
14438 100mg $228 Buy

1,5-Isoquinolinediol Chemical Properties, Uses, Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50 = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Uses

Reagent used in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

[1] M BANASIK. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.[J]. The Journal of Biological Chemistry, 1992, 267 3: 1569-1575.
[2] T RUSCETTI. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.[J]. The Journal of Biological Chemistry, 1998, 273 23: 14461-14467. DOI: 10.1074/jbc.273.23.14461
[3] PRABAL K. CHATTERJEE. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo[J]. FASEB Journal, 2000, 14 5: 641-651. DOI: 10.1096/fasebj.14.5.641
[4] J BOWES. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.[J]. Cardiovascular Research, 1999, 41 1: 126-134. DOI: 10.1016/s0008-6363(98)00221-1
[5] JOO-YUN BYUN. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.[J]. Molecular Pharmacology, 2009, 76 4: 734-744. DOI: 10.1124/mol.109.056259
[6] YOUNG-HEE KANG. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.[J]. Cancer research, 2004, 64 24: 8960-8967. DOI: 10.1158/0008-5472.can-04-1830

1,5-Isoquinolinediol Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate

1,5-Isoquinolinediol Suppliers

Global Suppliers ( 129)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
China Langchem Inc. 0086-21-58956006 China 7798 57
Shanghai potentpharm CO.,Ltd (86) 21 51969655 China 486 22
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Shandong Xiya Chemical Co., Ltd 57
China Langchem Inc. 57
Shanghai potentpharm CO.,Ltd 22
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55

View Latest Price from 1,5-Isoquinolinediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,5-Isoquinolinediol pictures 2026-09-17 1,5-Isoquinolinediol
5154-02-9
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1,5-Isoquinolinediol pictures 2026-08-08 1,5-Isoquinolinediol
5154-02-9
 $45.00-73.00 99.35% 10g TargetMol Chemicals Inc.

1,5-Isoquinolinediol Spectrum

1,5-ISOQUINOLINEDIOL(5154-02-9)1HNMR

5154-02-9 (1,5-Isoquinolinediol) Related Search:

5-Hydroxyisoquinoline Isoquinoline Isocarbostyril 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol Tretoquinol
(S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride DL-Laudanosoline hydrobromide trihydrate 1,5-Isoquinolinediol 1,2,3,4-Tetrahydro-6,7-isoquinolinediol hydrobromide (+/-)-Tetrahydropapaveroline hydrobromide
6,7-Dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide 6,7-Isoquinolinediol, 1-propyl- (9CI) d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI) 6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI)
Tretoquinol hydrochloride (R)-1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol 6,7-Isoquinolinediol, 2-ethyl-1,2,3,4-tetrahydro-1,1-dimethyl- (9CI)

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1,5-DIHYDROXYISOQUINOLINE 5-HYDROXYISOCARBOSTYRIL 5-HYDROXY-1(2H)-ISOQUINOLINE 5-HYDROXY-1(2H)-ISOQUINOLINONE 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE) 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ 5-Hydroxyisoquinoline-1(2H)-one 1,5-Isoquinolinediol,98% 1,5-dihydroxy-1(2H)-isoquinoline 1,5-Isoquinolinediol ,97% isoquinoline-1,5-diol 5-hydroxyisoquinolin-1(2H)-one 5-Hydroxy-isoquinolinone NSC 65585 DIQ 1(2H)-Isoquinolinone, 5-hydroxy- 5-hydroxy-1,2-dihydroisoquinolin-1-one Isoquinolinediol, 1,5- - NSC 65585 PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase 1,5-Isoquinolinediol, PARP-1 inhibitor 1,5-Isoquinolinediol, 10 mM in DMSO PARP Inhibitor IV, IQD 1,5-Isoquinolinediol - [K94620] DHQ 1,5-Isoquinolinediol 5154-02-9 PARP Regulators PARP BioChemical Apoptosis and Cell Cycle Cell Signaling and Neuroscience Cell Biology Aromatics Inhibitors