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1,5-ISOQUINOLINEDIOL

1,5-ISOQUINOLINEDIOL structure

CAS No.: 5154-02-9

Chemical Name:: 1,5-ISOQUINOLINEDIOL

Synonyms: DHQ;DIQ;NSC 65585;1,5-ISOQUINOLINEDIOL;isoquinoline-1,5-diol;PARP Inhibitor IV, IQD;5-HYDROXYISOCARBOSTYRIL;1,5-Isoquinolinediol,98%;5-Hydroxy-isoquinolinone;1,5-DIHYDROXYISOQUINOLINE

CBNumber:: CB5360303

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MDL Number:: MFCD00006900

MOL File:: 5154-02-9.mol

MSDS File:: SDS

Last updated:2025-09-28 10:37:47

Product description	Number	Pack Size	Price
PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.	419800	5MG	$96.4
1,5-Isoquinolinediol ≥98% (HPLC), powder	I138	5MG	$59.9
1,5-Isoquinolinediol ≥98%	14438	5mg	$36
1,5-Isoquinolinediol ≥98%	14438	25mg	$78
1,5-Isoquinolinediol ≥98%	14438	100mg	$207
More product size

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1,5-ISOQUINOLINEDIOL Properties

Melting point	270-275 °C
Boiling point	287.44°C (rough estimate)
Density	1.2480 (rough estimate)
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO: >36 mg/mL
form	solid
pka	8.52±0.20(Predicted)
color	off-white
InChI	InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChIKey	LFUJIPVWTMGYDG-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C(O)=CC=C2)C=CN1
CAS DataBase Reference	5154-02-9(CAS DataBase Reference)
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HS Code

29337900

NFPA 704

	0
2		0

1,5-ISOQUINOLINEDIOL price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	419800	PARP Inhibitor IV, IQD - CAS 1188540 - Calbiochem The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.	5154-02-9	5MG	$96.4	2023-01-07	Buy
Sigma-Aldrich	I138	1,5-Isoquinolinediol ≥98% (HPLC), powder	5154-02-9	5MG	$59.9	2022-05-15	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	5mg	$36	2024-03-01	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	25mg	$78	2024-03-01	Buy
Cayman Chemical	14438	1,5-Isoquinolinediol ≥98%	5154-02-9	100mg	$207	2024-03-01	Buy

Product number	Packaging	Price	Buy
419800	5MG	$96.4	Buy
I138	5MG	$59.9	Buy
14438	5mg	$36	Buy
14438	25mg	$78	Buy
14438	100mg	$207	Buy

1,5-ISOQUINOLINEDIOL Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Uses

Reagent used in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

[1] M BANASIK. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.[J]. The Journal of Biological Chemistry, 1992, 267 3: 1569-1575.
[2] T RUSCETTI. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.[J]. The Journal of Biological Chemistry, 1998, 273 23: 14461-14467. DOI: 10.1074/jbc.273.23.14461
[3] PRABAL K. CHATTERJEE. Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo[J]. FASEB Journal, 2000, 14 5: 641-651. DOI: 10.1096/fasebj.14.5.641
[4] J BOWES. Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.[J]. Cardiovascular Research, 1999, 41 1: 126-134. DOI: 10.1016/s0008-6363(98)00221-1
[5] JOO-YUN BYUN. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.[J]. Molecular Pharmacology, 2009, 76 4: 734-744. DOI: 10.1124/mol.109.056259
[6] YOUNG-HEE KANG. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.[J]. Cancer research, 2004, 64 24: 8960-8967. DOI: 10.1158/0008-5472.can-04-1830

1,5-ISOQUINOLINEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate

1,5-ISOQUINOLINEDIOL Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14360	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850 +86-13986145403;	info@fortunachem.com	China	5999	58
Henan Alfa Chemical Co., Ltd	+8615838112936	alfa10@alfachem.cn	China	12931	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39032	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Wuhan Fortuna Chemical Co., Ltd	58
Henan Alfa Chemical Co., Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from 1,5-ISOQUINOLINEDIOL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-20	1,5-Isoquinolinediol 5154-02-9	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
	2025-09-28	1,5-Isoquinolinediol 5154-02-9	US $45.00-73.00 / mg		99.21%	10g	TargetMol Chemicals Inc.

1,5-Isoquinolinediol
5154-02-9
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

1,5-Isoquinolinediol
5154-02-9
US $45.00-73.00 / mg
99.21%
TargetMol Chemicals Inc.

5154-02-9(1,5-ISOQUINOLINEDIOL)Related Search:

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1,5-ISOQUINOLINEDIOL 1,5-DIHYDROXYISOQUINOLINE 5-HYDROXYISOCARBOSTYRIL 5-HYDROXY-1(2H)-ISOQUINOLINE 5-HYDROXY-1(2H)-ISOQUINOLINONE 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE) 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ 5-Hydroxyisoquinoline-1(2H)-one DHQ 1,5-Isoquinolinediol,98% 1,5-dihydroxy-1(2H)-isoquinoline 1,5-Isoquinolinediol ,97% isoquinoline-1,5-diol 5-hydroxyisoquinolin-1(2H)-one 5-Hydroxy-isoquinolinone NSC 65585 DIQ 1(2H)-Isoquinolinone, 5-hydroxy- 5-hydroxy-1,2-dihydroisoquinolin-1-one Isoquinolinediol, 1,5- - NSC 65585 PARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,NADPH,1,5-Isoquinolinediol,Inhibitor,1,5Isoquinolinediol,oxidase,poly ADP ribose polymerase 1,5-Isoquinolinediol, PARP-1 inhibitor 1,5-Isoquinolinediol, 10 mM in DMSO PARP Inhibitor IV, IQD 1,5-Isoquinolinediol - [K94620] 5154-02-9 PARP Regulators PARP BioChemical Apoptosis and Cell Cycle Cell Signaling and Neuroscience Cell Biology Aromatics Inhibitors