5-Hydroxyisoquinoline
- CAS No.
- 2439-04-5
- Chemical Name:
- 5-Hydroxyisoquinoline
- Synonyms
- ISOQUINOLIN-5-OL;NSC 51787;5-ISOQUINOLINOL;Isoquinoline-5-ol;5-Hydroxyisoquinolne;5-Hydroxyisoquin din;5-HYDROXYISOQUINOLINE;5-Hydroxyisoquin dine;5-Hydroxyisoquinoline90%;5-Hydroxyisoquinoline>
- CBNumber:
- CB9174379
- Molecular Formula:
- C9H7NO
- Molecular Weight:
- 145.16
- MDL Number:
- MFCD00006906
- MOL File:
- 2439-04-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 213-215 |
|---|---|
| Boiling point | 264.27°C (rough estimate) |
| Density | 1.1555 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 8.53±0.40(Predicted) |
| form | Granular Powder |
| color | Beige |
| InChI | InChI=1S/C9H7NO/c11-9-3-1-2-7-6-10-5-4-8(7)9/h1-6,11H |
| InChIKey | CSNXUYRHPXGSJD-UHFFFAOYSA-N |
| SMILES | C1C2=C(C(O)=CC=C2)C=CN=1 |
| CAS DataBase Reference | 2439-04-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Hydroxyisoquinoline price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H33207 | 5-Hydroxyisoquinoline technical grade, 90% | 2439-04-5 | 5g | $182 | 2026-04-30 | Buy |
| Sigma-Aldrich | H33207 | 5-Hydroxyisoquinoline technical grade, 90% | 2439-04-5 | 25g | $436 | 2023-06-20 | Buy |
| TCI Chemical | H1259 | 5-Hydroxyisoquinoline >96.0%(GC)(T) | 2439-04-5 | 5g | $200 | 2026-04-30 | Buy |
| TCI Chemical | H1259 | 5-Hydroxyisoquinoline >96.0%(GC)(T) | 2439-04-5 | 25g | $705 | 2026-04-30 | Buy |
| Biosynth | FH24373 | 5-Hydroxyisoquinoline | 2439-04-5 | 25g | $288.25 | 2026-06-04 | Buy |
5-Hydroxyisoquinoline Chemical Properties, Uses, Production
Chemical Properties
beige granular powder
Uses
5-Hydroxyisoquinoline is a reagent used in the preparation of PARP inhibitor.
Synthesis
27655-40-9
2439-04-5
The general procedure for the synthesis of 5-hydroxyisoquinoline from 5-isoquinolinesulfonic acid is as follows: 23 g of 5-isoquinolinesulfonic acid is added to 400 ml of water, followed by 60 g of sodium hydroxide. The reaction mixture was heated to reflux and stirred continuously under this condition for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with dilute hydrochloric acid to 5. Then, ethyl acetate was added for extraction and the organic phase was separated and collected. The organic phase was concentrated and the resulting residue was purified by silica gel column chromatography to yield 16 g of 5-hydroxyisoquinoline.
References
[1] Acta Poloniae Pharmaceutica, 1994, vol. 51, # 6, p. 479 - 482
[2] Patent: CN107778231, 2018, A. Location in patent: Paragraph 0023; 0024
5-Hydroxyisoquinoline Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Anchor Biological Technology Co., Ltd | 0519-85519868 18915088878 | sales@ankerbio.com | China | 260 | 58 |
| Changzhou Xinda Biotechnology Co., Ltd | 0519-85519868 18915088878 | xiaoweng106108@163.com | China | 99 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 5-Hydroxyisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 5-Hydroxyisoquinoline
2439-04-5
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2025-12-24 | 5-Hydroxyisoquinoline
2439-04-5
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2022-02-19 | 5-Hydroxyisoquinoline | 1KG | 97.7% | 100 tons | Honest Joy Holdings Limited |
-
- 5-Hydroxyisoquinoline
2439-04-5
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-Hydroxyisoquinoline
2439-04-5
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Hydroxyisoquinoline
- $0.00
- 97.7%
- Honest Joy Holdings Limited
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