ANISOMYCIN
- CAS No.
- 22862-76-6
- Chemical Name:
- ANISOMYCIN
- Synonyms
- Nsc76712;Nsc147340;Aids031977;ANISOMYCIN;FLAGECIDIN;Aids-031977;Wuningmeisu C;4-beta))-alph;Anisomycin>(-)-anisomycin
- CBNumber:
- CB5363672
- Molecular Formula:
- C14H19NO4
- Molecular Weight:
- 265.3
- MDL Number:
- MFCD00077650
- MOL File:
- 22862-76-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 140-141 C |
|---|---|
| alpha | D23 -30° (methanol) |
| Boiling point | 408.52°C (rough estimate) |
| Density | 1.1356 (rough estimate) |
| refractive index | 1.5230 (estimate) |
| Flash point | 87℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | methanol: 20 mg/mL, clear, colorless to faintly yellow |
| form | solid |
| pka | 7.9(at 25℃) |
| color | white |
| Water Solubility | Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml |
| λmax | 283nm(EtOH)(lit.) |
| Merck | 14,670 |
| BRN | 20705 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 |
| InChIKey | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
| SMILES | COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1 |
| EWG's Food Scores | 1 |
| FDA UNII | 6C74YM2NGI |
| UNSPSC Code | 51102829 |
| NACRES | NA.85 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-36-26 | |||||||||
| RIDADR | UN 3462 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BZ9800000 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Toxicity | LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55 | |||||||||
| NFPA 704 |
|
ANISOMYCIN price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9789 | Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid | 22862-76-6 | 5mg | $62 | 2026-04-30 | Buy |
| Sigma-Aldrich | A5862 | Anisomycin, Ready Made Solution from Streptomyces griseolus | 22862-76-6 | 0.5ml | $230 | 2026-04-30 | Buy |
| TCI Chemical | A2613 | Anisomycin >97.0%(GC) | 22862-76-6 | 25mg | $187 | 2026-04-30 | Buy |
| TCI Chemical | A2613 | Anisomycin >97.0%(GC) | 22862-76-6 | 100mg | $549 | 2026-04-30 | Buy |
| Cayman Chemical | 11308 | Anisomycin ≥98% | 22862-76-6 | 5mg | $38 | 2026-04-30 | Buy |
ANISOMYCIN Chemical Properties,Uses,Production
Description
Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable.
Chemical Properties
Crystalline
Uses
Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.
Uses
It is applied as an antiparasitic agent and antineoplastic agent. It acts as a protein synthesis inhibitor (blocks translation), potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. It also scts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
Definition
ChEBI: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Biological Activity
Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Safety Profile
Poison by ingestion,intraperitoneal, subcutaneous, and intravenous routes.When heated to decomposition it emits toxic fumes ofNOx.
storage
+4°C
Background
Anisomycin, an antibiotic produced by Streptomyces griseolus and S. roseochromogenes, was originally described to inhibit protein-protein synthesis at the translational level. More recently, it is has been well characterized to strongly activate the stress kinases SAPK/JNK and p38 MAPK, as well as p70/85 S6 kinase in mammalian cells, which results in the rapid induction of immediate-early genes, such as c-fos, fosB, c-jun, JunB, and JunD. Investigators have demonstrated that anisomycin acts as a potent signaling agonist, synergizing with growth factors and phorbol esters to superinduce these IE genes. Research studies have demonstrated that anisomycin induces apoptosis in many cancer cell lines.
References
[1] C A HAZZALIN. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.[J]. Molecular and Cellular Biology, 1998, 18 4: 1844-1854. DOI:10.1128/mcb.18.4.1844
[2] IMTIAZ A MAWJI. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.[J]. Cancer research, 2007, 67 17: 8307-8315. DOI:10.1158/0008-5472.can-07-1687
ANISOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Hubei widely chemical technology Co., Ltd. | 027-83991130 18627774460 | 1718093273@QQ.COM | China | 1618 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Wuhan SynBioLily Biotechnology Co.,Ltd. | 18971458902 | yangsong@synbiolily.com | China | 482 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Taizhou Chemedir Biopharm-tech. Co., Ltd | 0523-86200218 18994667082 | sale1_cmd@chemedir.com | China | 58 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from ANISOMYCIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-13 | Anisomycin
22862-76-6
|
$1.00 | 1g | 0.98 | 1000 | Apeloa production Co.,Limited | |
 |
2021-11-27 | ANISOMYCIN
22862-76-6
|
$8000.00 | 100g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2019-07-06 | ANISOMYCIN
22862-76-6
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Anisomycin
22862-76-6
- $1.00
- 0.98
- Apeloa production Co.,Limited
-
- ANISOMYCIN
22862-76-6
- $8000.00
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- ANISOMYCIN
22862-76-6
- $1.00
- 95%-99%
- Career Henan Chemical Co
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