2-Methyl-1,3-thiazole-4-carboxylic acid
- CAS No.
- 35272-15-2
- Chemical Name:
- 2-Methyl-1,3-thiazole-4-carboxylic acid
- Synonyms
- BUTTPARK 98\06-12;CHEMBRDG-BB 4400182;RARECHEM AL BO 0660;2-Methyl-Thiazole-4-Carboxylic;4-Carboxy-2-methyl-1,3-thiazole;2-Methyl-4-thiazolecarboxylic Acid;2-METHYL-THIAZOLE-4-CARBOXYLIC ACID;4-Thiazolecarboxylic acid, 2-methyl-;2-Methylthiazole-4-carboxylic acid 97%;2-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
- CBNumber:
- CB5372845
- Molecular Formula:
- C5H5NO2S
- Molecular Weight:
- 143.16
- MDL Number:
- MFCD03407332
- MOL File:
- 35272-15-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 148 °C |
|---|---|
| Boiling point | 301.2±15.0 °C(Predicted) |
| Density | 1.418±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 4.28±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | 1S/C5H5NO2S/c1-3-6-4(2-9-3)5(7)8/h2H,1H3,(H,7,8) |
| InChIKey | ZHDRDZMTEOIWSX-UHFFFAOYSA-N |
| SMILES | Cc1nc(cs1)C(O)=O |
| CAS DataBase Reference | 35272-15-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29341000 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
2-Methyl-1,3-thiazole-4-carboxylic acid price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 718440 | 2-Methylthiazole-4-carboxylic acid 97% | 35272-15-2 | 1g | $70.5 | 2023-06-20 | Buy |
| TCI Chemical | M2802 | 2-Methylthiazole-4-carboxylic Acid >98.0%(GC)(T) | 35272-15-2 | 1g | $79 | 2026-04-30 | Buy |
| TCI Chemical | M2802 | 2-Methylthiazole-4-carboxylic Acid >98.0%(GC)(T) | 35272-15-2 | 5g | $250 | 2026-04-30 | Buy |
| Activate Scientific | AS50438 | 2-Methylthiazole-4-carboxylic acid 97% | 35272-15-2 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS50438 | 2-Methylthiazole-4-carboxylic acid 97% | 35272-15-2 | 5g | $40 | 2026-06-04 | Buy |
2-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White to orange to tan solid
Synthesis
6436-59-5
35272-15-2
The general procedure for the synthesis of 2-methyl-4-thiazolecarboxylic acid using ethyl 2-methylthiazole-4-carboxylate as starting material is as follows: 1. dissolve ethyl 2-methylthiazole-4-carboxylate in tetrahydrofuran (THF). 2. add 10% (w/v) aqueous solution of potassium hydroxide (KOH) to the above solution. 3. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete disappearance of the raw material. 4. pH of the reaction solution was adjusted to 4 with 1 M hydrochloric acid (HCl). 5. The reaction solution was extracted with ethyl acetate (EtOAc). 6. 6. The organic phase was dried with anhydrous magnesium sulfate (MgSO). 7. The organic phase was concentrated to give the target product 2-methyl-4-thiazolecarboxylic acid.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 31
[4] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 6, p. 703 - 709
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23
2-Methyl-1,3-thiazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 2-Methyl-1,3-thiazole-4-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
|
$1.60-6.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-06-30 | 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2024-08-17 | 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
- $1.60-6.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Methyl-1,3-thiazole-4-carboxylic acid
35272-15-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
