ChemicalBook >> CAS DataBase List >>2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran structure

CAS No.: 81926-24-1

Chemical Name:: 2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran

Synonyms: SKL124;5-b]difuran;7-Tetrahydro-benzo[1;2,3,6,7-Tetrahydro-benzo[1,2-b;2,3,6,7-Tetrahydrobenzo[1,2-B:4,5-B']Furan;2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran;2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']difuran;2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran;Benzo[1,2-b:4,5-b']difuran,2,3,6,7-tetrahydro-;2,3,6,7-tetrahydrobenzenebenzo[1,2-b:4,5-b']difuran

CBNumber:: CB5393949

Molecular Formula:: C10H10O2

Molecular Weight:: 162.19

MDL Number:: MFCD08436969

MOL File:: 81926-24-1.mol

MSDS File:: SDS

Last updated:2026-05-28 03:20:33

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2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran Properties

Melting point	155 °C
Boiling point	287.9±40.0 °C(Predicted)
Density	1.250±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Acetone, Chloroform, Dichloromethane, Ethyl Acetate
form	Solid
color	White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	130244	2,3,6,7-Tetrahydro-benzo[1,2-b;4,5-b']difuran	81926-24-1	50.00mg	$180	2026-05-18	Buy
Matrix Scientific	130244	2,3,6,7-Tetrahydro-benzo[1,2-b;4,5-b']difuran	81926-24-1	500.00mg	$1190	2026-05-18	Buy
Synthonix	T52440	2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']difuran 97%	81926-24-1	250mg	$70	2026-05-06	Buy
Synthonix	T52440	2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']difuran 97%	81926-24-1	1g	$77	2026-05-06	Buy
Synthonix	T52440	2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']difuran 97%	81926-24-1	5g	$80	2026-05-06	Buy

Product number	Packaging	Price	Buy
130244	50.00mg	$180	Buy
130244	500.00mg	$1190	Buy
T52440	250mg	$70	Buy
T52440	1g	$77	Buy
T52440	5g	$80	Buy

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran can be reagent used in the preparation of potent 5-HT2 receptor agonists.

Synthesis

1,4-Bis(2-chloroethoxy)-2,5-dibromobenzene

178557-12-5

81926-24-1

General procedure for the synthesis of 2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran from 1,4-dibromo-2,5-bis(2-chloroethoxy)benzene: 10.50 g (26.6 mmol) of 1,4-dibromo-2,5-bis(2-chloroethoxy)benzene was dissolved in 250 mL of anhydrous tetrahydrofuran under the protection of nitrogen and the solution was cooled to 0°C. Using a syringe equipped with a large gauge needle, a 2.5 M hexane solution of n-butyllithium (23.52 mL, 2.2 eq.) was quickly (within 7 seconds) added to the rapidly stirred solution. The reaction mixture was continued to be stirred for 10 minutes before the solvent was removed under vacuum. The residue was partitioned between ethyl acetate and water and the organic phase was dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent was petroleum ether 60-90 °C: ethyl acetate = 20:1) to afford the target product 2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran (3.47 g, 80% yield) as white crystals. The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 6.63 (2H, s), 4.52 (4H, t, J=8.6 Hz), 3.13 (4H, t, J=8.5 Hz); NMR carbon spectrum (75 MHz, CDCl3): δ 154.12 (C), 125.93 (C), 105.88 (CH). 71.51 (CH2), 30.31 (CH2).

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 15, p. 2953 - 2961
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1808 - 1814
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 6, p. 1003 - 1010

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran Preparation Products And Raw materials

Raw materials

1,4-Bis(2-chloroethoxy)-2,5-dibromobenzene Hexane n-Butyllithium Tetrahydrofuran

Preparation Products

4-Formyl-2,3,6,7-Tetrahydrobenzo[1,2-B:4,5-B']Difuran

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran Suppliers

Global Suppliers ( 75)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
ZhengZhou HuaWen Chemical Co.Ltd	0370-2785118 17550508557	675141927@qq.com	China	3201	55
Shanghai Arbor Chemical Co., Ltd.	021-60451683 15021268886	sales@arborchemical.com	China	837	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.	0371-0371-13526885213 15637198702	hsyykjchem@163.com	China	1860	58
Zhengzhou Gecko Scientific Inc.	0371-63336364 17344886665	209932355@qq.com	China	535	55
Zhengzhou AnMusi Chemical Products Co., Ltd.	15981811963 18737195735	2370407954@qq.com	China	1979	55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	028-83379370 13880556291	tcy@tcypharm.com	China	8696	58
Aikon International Limited	025-58859352 19370895928	sales01@aikonchem.com	China	15078	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
ZhengZhou HuaWen Chemical Co.Ltd	55
Shanghai Arbor Chemical Co., Ltd.	55
Bide Pharmatech Ltd.	60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.	58
Zhengzhou Gecko Scientific Inc.	55
Zhengzhou AnMusi Chemical Products Co., Ltd.	55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	58
Aikon International Limited	58

View Latest Price from 2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-01	Benzo[1,2-b:4,5-b']difuran,2,3,6,7-tetrahydro- 81926-24-1		10g	98%	10kg	Zhengzhou Gecko Scientific Inc.

Benzo[1,2-b:4,5-b']difuran,2,3,6,7-tetrahydro-
81926-24-1
98%
Zhengzhou Gecko Scientific Inc.

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran Spectrum

2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran(81926-24-1)¹HNMR

81926-24-1 (2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran) Related Search:

Tetrahydrofuran-3-carboxaldehyde Tetrahydrofurfuryl chloride 2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b:4,5-b']difuran-4-yl)-1-methyl-ethylamine 1-(8-bromo-2,3,6,7-tetrahydrobenzo(1,2-b:4,5-b')difuran-4-yl)-2-aminopropane (3aS)-4,8-Dimethyl-3-methylene-4β-ethenyl-3aβ,4,5,8bβ-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one

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1of2

2,3,6,7-tetrahydrofuro[2,3-f][1]benzofuran 2,3,6,7-Tetrahydro-benzo[1,2-b 2,3,6,7-Tetrahydrobenzo[1,2-B:4,5-B']Furan Benzo[1,2-b:4,5-b']difuran,2,3,6,7-tetrahydro- 5-b]difuran 7-Tetrahydro-benzo[1 4,10-dioxatricyclo[7.3.0.0,3,7]dodeca-1,3(7),8-triene SKL124 2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b']difuran 4,10-dioxatricyclo[7.3.0.0?3,a?·]dodeca-1,3(7),8-triene 2,3,6,7-Tetrahydrobenzo[1,2-b:4,5-b′]difuran, CAS 81926-24-1 2,3,6,7-Tetrahydro-benzo[1,2-b:4,5-b']difuran 2,3,6,7-tetrahydrobenzenebenzo[1,2-b:4,5-b']difuran 81926-24-1 Aromatics Intermediates & Fine Chemicals Pharmaceuticals