6-Quinolinecarbaldehyde
- CAS No.
- 4113-04-6
- Chemical Name:
- 6-Quinolinecarbaldehyde
- Synonyms
- QUINOLINE-6-CARBALDEHYDE;6-QUINOLINECARBOXALDEHYDE;inecarbaL;AKOS AUF01714;6-Formylquinoline;AKOS BBS-00005338;6-quinolineMethanal;RARECHEM AK ML 0559;6-QUINOLINECARBALDEHYDE;QUINOLINE-6-CARBOXALDEHYDE
- CBNumber:
- CB5408618
- Molecular Formula:
- C10H7NO
- Molecular Weight:
- 157.17
- MDL Number:
- MFCD00805836
- MOL File:
- 4113-04-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 74-75°C |
|---|---|
| Boiling point | 314.3±15.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | 4.13±0.10(Predicted) |
| color | White to Yellow to Green |
| InChI | 1S/C10H7NO/c12-7-8-3-4-10-9(6-8)2-1-5-11-10/h1-7H |
| InChIKey | VUAOIXANWIFYCU-UHFFFAOYSA-N |
| SMILES | O=Cc1ccc2ncccc2c1 |
| CAS DataBase Reference | 4113-04-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P501-P270-P264-P301+P312+P330 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/38-36 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
6-Quinolinecarbaldehyde price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | Q0097 | 6-Quinolinecarboxaldehyde >98.0%(GC)(T) | 4113-04-6 | 1g | $110 | 2026-04-30 | Buy |
| TCI Chemical | Q0097 | 6-Quinolinecarboxaldehyde >98.0%(GC)(T) | 4113-04-6 | 5g | $387 | 2026-04-30 | Buy |
| Usbiological | 234822 | 6-Quinolinecarbaldehyde ≥95% (HPLC) ≥95%(HPLC) | 4113-04-6 | 1g | $215 | 2026-06-03 | Buy |
| Usbiological | 234822 | 6-Quinolinecarbaldehyde ≥95% (HPLC) ≥95%(HPLC) | 4113-04-6 | 5g | $360 | 2026-06-03 | Buy |
| Usbiological | 234822 | 6-Quinolinecarbaldehyde ≥95% (HPLC) ≥95%(HPLC) | 4113-04-6 | 25g | $1217 | 2026-06-03 | Buy |
6-Quinolinecarbaldehyde Chemical Properties, Uses, Production
Chemical Properties
white to light yellow powde
Synthesis
100516-88-9
4113-04-6
General procedure for the synthesis of quinoline-6-carbaldehyde from 6-hydroxymethylquinoline: method adapted from Meyers et al. (Meyers, A. G.; Zhong, B.; Movassaghi, M.; Kung, D. W.; Lanman, B. A.; Kwon, S. Tetrahedron Lett. 2000, 41, 1359-1362). Dess-Martin periodinane (2.57 g, 6.05 mmol) was added to a 0.28 M solution of 6-hydroxymethylquinoline (0.459 g, 2.88 mmol) in water-saturated dichloromethane (10 mL). The reaction mixture was stirred for 10 min and then dichloromethane (3 x 1 mL) was added in batches over 15 min. Subsequently, the reaction mixture was diluted with ether (10 mL) and 80% saturated aqueous sodium bicarbonate solution (10 mL) of sodium thiosulfate (7.87 g, 31.7 mmol) was added. The mixture was stirred rapidly for 45 minutes. The organic and aqueous layers were separated and the aqueous layer was extracted with ether (2 x 20 mL). The combined organic layers were washed sequentially with saturated aqueous sodium bicarbonate solution (30 mL), water (2 x 30 mL) and saturated sodium chloride solution (2 x 30 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (30-60% ethyl acetate/hexane) to give 0.383 g (85%) of quinoline-6-carbaldehyde (S4a) as a white solid with a melting point of 76.2-76.5 °C. 1H NMR (400 MHz, CDCl3): δ 7.53 (dd, 1H, J = 4.4, 8.4 Hz), 8.18-8.23 (m, 2H ), 8.33 (dd, 1H, J = 2.0, 8.4 Hz), 8.36 (s, 1H), 9.05 (dd, 1H, J = 2.0, 4.4 Hz), 10.20 (s, 1H).13C NMR (100 MHz, CDCl3): δ 122.4, 126.8, 127.8, 130.9, 133.8, 134.4 , 137.6, 151.0, 153.3, 191.6. HRMS-FAB (m/z): calculated value of 157.0528 for [MH]+ C10H7NO; measured value of 157.0521.
References
[1] Patent: WO2004/7491, 2004, A1. Location in patent: Page 56
[2] Journal of the American Chemical Society, 2008, vol. 130, # 20, p. 6404 - 6410
[3] Patent: WO2009/75778, 2009, A2. Location in patent: Page/Page column 49; 50-51
[4] Patent: US2005/54670, 2005, A1. Location in patent: Page/Page column 27
6-Quinolinecarbaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
View Latest Price from 6-Quinolinecarbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 6-Quinolinecarbaldehyde
4113-04-6
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 6-Quinolinecarbaldehyde
4113-04-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
