1,4-Difluoro-2-methyl-5-nitrobenzene
- CAS No.
- 141412-60-4
- Chemical Name:
- 1,4-Difluoro-2-methyl-5-nitrobenzene
- Synonyms
- 2-Difluoro-4-nitrotoluene;2，5-Difluoro-4-nitrotoluene;2,5-Difluoro-4-methyinitrobenzene;2,5-Difluoro-4-methylnitrobenzene;4-DIFLUORO-2-METHYL-5-NITROBENZENE;1,4-Difluoro-2-methyl-5-nitrobenzene;Benzene, 1,4-difluoro-2-methyl-5-nitro-;1,4-DIFLUORO-2-METHYL-5-NITROBENZENE ISO 9001：2015 REACH;1,4-Difluoro-2-Methyl-5-nitrobenzene[2,5-difluoro-4-nitrotoluene];2,5-Difluoro-4-methylnitrobenzene, 1,4-Difluoro-2-methyl-5-nitrobe
- CBNumber:
- CB5420294
- Molecular Formula:
- C7H5F2NO2
- Molecular Weight:
- 173.12
- MDL Number:
- MFCD06200905
- MOL File:
- 141412-60-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 25 °C |
|---|---|
| Boiling point | 251 ºC |
| Density | 1.374 |
| Flash point | 121 ºC |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to lump to clear liquid |
| color | White or Colorless to Yellow to Green |
| CAS DataBase Reference | 141412-60-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2904990090 | |||||||||
| NFPA 704 |
|
1,4-Difluoro-2-methyl-5-nitrobenzene price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4806 | 2,5-Difluoro-4-nitrotoluene >98.0%(GC) | 141412-60-4 | 1g | $66 | 2026-04-30 | Buy |
| TCI Chemical | D4806 | 2,5-Difluoro-4-nitrotoluene >98.0%(GC) | 141412-60-4 | 5g | $200 | 2026-04-30 | Buy |
| Apolloscientific | PC10366 | 2,5-Difluoro-4-nitrotoluene ≥95% | 141412-60-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC10366 | 2,5-Difluoro-4-nitrotoluene ≥95% | 141412-60-4 | 25g | $48 | 2026-06-04 | Buy |
| Apolloscientific | PC10366 | 2,5-Difluoro-4-nitrotoluene ≥95% | 141412-60-4 | 100g | $184 | 2026-06-04 | Buy |
1,4-Difluoro-2-methyl-5-nitrobenzene Chemical Properties, Uses, Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 2321, 1992 DOI: 10.1021/jm00090a024
Synthesis
452-67-5
141412-60-4
General procedure for the synthesis of 2,5-difluoro-4-nitrotoluene from 2,5-difluorotoluene: To a stirred solution of 2,5-difluorotoluene (0.544 g, 4.25 mmol, Aldrich, for direct use) in concentrated sulfuric acid (5.0 mL) was added a single addition of potassium nitrate (KNO3, 0.430 g, 4.25 mmol) at 0 °C. The reaction mixture was gradually warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by pouring into ice (25 g) and extracted with ethyl acetate (40 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 2,5-difluoro-4-nitrotoluene (0.555 g, 91% yield) as a light red oil. The product was characterized by 1H NMR (CDCl3): δ 2.369 (d, 3H, J = 1.8 Hz), 7.127 (dd, 1H, J1 = 8.1 Hz, J2 = 6.0 Hz), 7.734 (dd, 1H, J1 = 8.4 Hz, J2 = 6.3 Hz).
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2321 - 2327
[2] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842
[3] Patent: US5631373, 1997, A
[4] Patent: WO2008/119720, 2008, A1. Location in patent: Page/Page column 54
1,4-Difluoro-2-methyl-5-nitrobenzene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 1,4-Difluoro-2-methyl-5-nitrobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
141412-60-4
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2022-01-27 | 1,4-Difluoro-2-methyl-5-nitrobenzene
141412-60-4
|
1KG | 97.2% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-02-26 | 1,4-Difluoro-2-methyl-5-nitrobenzene
141412-60-4
|
1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 1,4-DIFLUORO-2-METHYL-5-NITROBENZENE
141412-60-4
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1,4-Difluoro-2-methyl-5-nitrobenzene
141412-60-4
- $0.00
- 97.2%
- Honest Joy Holdings Limited
-
- 1,4-Difluoro-2-methyl-5-nitrobenzene
141412-60-4
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
