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2-Aminopyrimidine-5-boronic Acid Pinacol Ester

2-Aminopyrimidine-5-boronic Acid Pinacol Ester structure

CAS No.: 402960-38-7

Chemical Name:: 2-Aminopyrimidine-5-boronic Acid Pinacol Ester

Synonyms: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine;CAS:402960-38-7;1H-PYRROL-3-OL,1-ETHYL-2-METHYL;5-METHOXYTHIOPHENE-2-BORONIC ACID;2-AMinopyriMidine-5-boronicacidpinacoleste;(2-Aminopyrimidin-5-yl)boronic acid pinaco;2-AMINOPYRIMIDINE-5-BORONIC ACID, PICOL ESTER;2-AMINOPYRIMIDINE-5-BORONIC ACID, PINACOL ESTER;(2-Aminopyrimidin-5-yl)boronic acid pinacol ester;5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

CBNumber:: CB5442173

Molecular Formula:: C10H16BN3O2

Molecular Weight:: 221.06

MDL Number:: MFCD06795685

MOL File:: 402960-38-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:42:34

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2-Aminopyrimidine-5-boronic Acid Pinacol Ester Properties

Melting point	209-211°C
Boiling point	394.8±34.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
pka	3.66±0.10(Predicted)
form	solid
color	white to off-white
Water Solubility	Slightly soluble in water. Soluble in chloroform.
InChI	InChI=1S/C10H16BN3O2/c1-9(2)10(3,4)16-11(15-9)7-5-13-8(12)14-6-7/h5-6H,1-4H3,(H2,12,13,14)
InChIKey	BPQVMIDUTRJYSC-UHFFFAOYSA-N
SMILES	C1(N)=NC=C(B2OC(C)(C)C(C)(C)O2)C=N1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P405-P501

Hazard Codes

Xi,Xn,T

Risk Statements

36/37/38-22-25

Safety Statements

26-36/37/39-36/39-45

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

TSCA

HazardClass

IRRITANT

HS Code

2933599590

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

NFPA 704

	1
2		0

2-Aminopyrimidine-5-boronic Acid Pinacol Ester price More Price(87)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	BML00109	2-Aminopyrimidine-5-boronic acid pinacol ester Aldrich	402960-38-7	1g	$114	2026-04-30	Buy
TCI Chemical	A3087	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine >98.0%(GC)(T)	402960-38-7	1g	$43	2026-04-30	Buy
TCI Chemical	A3087	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine >98.0%(GC)(T)	402960-38-7	5g	$151	2026-04-30	Buy
Usbiological	260081	2-Aminopyrimidine-5-boronic acid pinacol ester Asreported	402960-38-7	500mg	$319	2026-06-03	Buy
Usbiological	260081	2-Aminopyrimidine-5-boronic acid pinacol ester Asreported	402960-38-7	1g	$432	2026-06-03	Buy

Product number	Packaging	Price	Buy
BML00109	1g	$114	Buy
A3087	1g	$43	Buy
A3087	5g	$151	Buy
260081	500mg	$319	Buy
260081	1g	$432	Buy

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Chemical Properties, Uses, Production

Chemical Properties

Light Beige Solid

Uses

2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.

Synthesis

7752-82-1

73183-34-3

402960-38-7

General procedure for the synthesis of 2-aminopyrimidine-5-boronic acid pinacol ester from 2-amino-5-bromopyrimidine and bis(pinacolato)diboron and 5.9 g (60.3 mmol) potassium acetate: 3.5 g (20.1 mmol) 5-bromopyrimidin-2-amine, 5.6 g (22.1 mmol) bis(pinacolato)diboron, and 5.9 g (60.3 mmol) potassium acetate were dissolved in 35 mL of 1,4-dioxane and subsequently 1.41 g (2.01 mmol) of bis(triphenylphosphine)dichloropalladium(II) was added. The reaction mixture was stirred at 110 °C for 4 hours. After completion of the reaction, it was cooled to room temperature, diluted with ethyl acetate and sonicated for 5 minutes. It was filtered through a diatomaceous earth filled filter and washed with ethyl acetate. The filtrate was washed sequentially with distilled water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was dissolved in 100 mL of a solvent mixture of dichloromethane and hexane (1:3, v/v) and stirred at room temperature for 1 hour. It was filtered under reduced pressure and the resulting solid was dried under reduced pressure to give 4 g (yield: 90%) of the target product 2-aminopyrimidine-5-boronic acid pinacol ester.

References

[1] Patent: KR2016/38598, 2016, A. Location in patent: Paragraph 0111; 0112
[2] Organic Process Research and Development, 2016, vol. 20, # 1, p. 95 - 99
[3] Organic Process Research and Development, 2017, vol. 21, # 9, p. 1427 - 1434
[4] Patent: CN106632443, 2017, A. Location in patent: Paragraph 0010-0016
[5] Patent: WO2007/84786, 2007, A1. Location in patent: Page/Page column 89-90

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Preparation Products And Raw materials

Raw materials

2-Amino-5-bromopyrimidine Ammonium hydroxide Pinacol Trimethyl borate 2-Chloropyrimidine-5-boronic acid pinacol ester

Bis(pinacolato)diboron 5-Bromo-N-(diphenylmethylene)-2-pyrimidinamine Potassium Acetate Bis(triphenylphosphine)palladium(II) chloride 1,4-Dioxane

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Preparation Products

2-(tert-Butoxycarbonylamino)pyrimidine-5-boronic acid, pinacol ester (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Cyclobutanecarbonitrile, 1-[6-(2-amino-5-pyrimidinyl)-3-pyridinyl]-

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Suppliers

Global Suppliers ( 267)

Supplier	Tel	Email	Country	ProdList	Advantage
skychemical Co.Ltd	021-20960837,QQ1332204249	sales@skychemical.com	China	3338	55
Shanghai Youmede Technology Co., LTD	18964944463	56810034@qq.com	China	40	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66

Supplier	Advantage
skychemical Co.Ltd	55
Shanghai Youmede Technology Co., LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
ChemFuture PharmaTech (Jiangsu) Ltd	65
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66

View Latest Price from 2-Aminopyrimidine-5-boronic Acid Pinacol Ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7	$1.10-36.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-08-20	2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-06-30	2-Aminopyrimidine-5-boronic Acid Pinacol Ester 402960-38-7		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

2-Aminopyrimidine-5-boronic Acid Pinacol Ester
402960-38-7
$1.10-36.00
99%
Henan Fengda Chemical Co., Ltd

2-Aminopyrimidine-5-boronic Acid Pinacol Ester
402960-38-7
$1.10
99.00%
Dideu Industries Group Limited

2-Aminopyrimidine-5-boronic Acid Pinacol Ester
402960-38-7
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-Aminopyrimidine-5-boronic Acid Pinacol Ester Spectrum

2-Aminopyrimidine-5-boronic Acid Pinacol Ester(402960-38-7)¹HNMR

402960-38-7 (2-Aminopyrimidine-5-boronic Acid Pinacol Ester) Related Search:

2-Aminopyrimidine-5-boronic Acid Pinacol Ester 2-(Morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester 2-Aminopyrimidine 2-Amino-pyrimidine-5-boronic acid Pyrimidine-5-boronic acid pinacol ester

1-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-piperidine-4-carboxylic acid 2-(tert-Butoxycarbonylamino)pyrimidine-5-boronic acid, pinacol ester 2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester 2-(Pyrrolidin-1-yl)pyrimidine-5-boronic acid pinacol ester 2-Amino-4-trifluoropyrimidine-5-boronic acid pinacol ester

3-Methoxythiophene-2-boronic acid pinacol ester 4-Benzyloxy-2-piperidine-1-yl-pyrimidine-5-boronic acid pinacol ester 2-Dimethylamino-pyrimidine-5-boronic acid pinacol ester 2-(4-Morpholino)pyrimidine-5-boronic acid pinacol ester 2-(Piperidin-1-yl)pyrimidine-5-boronic acid pinacol ester

2-(4-Boc-piperazin-1-yl)pyrimidine-5-boronic acid pinacol ester 5-Methoxythiophene-2-boronic acid pinacol ester 4-Benzyloxy-2-dimethylamino-pyrimidine-5-boronic acid

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2-AMINO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE 2-AMINOPYRIMIDINE-5-BORONIC ACID, PINACOL ESTER 5-METHOXYTHIOPHENE-2-BORONIC ACID 2-PyriMidinaMine,5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 2-Aminopyrimidine-5-boronic acid pinacol ester 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine, 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine, 2-aminopyrimidine-5-boronic acid pinacol ester, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-ylamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-ylamine, 2‐aminopyrimidine‐5‐boronic acid, pinacol ester, 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 2-AMINOPYRIMIDINE-5-BORONIC ACID, PICOL ESTER (2-Aminopyrimidin-5-yl)boronic acid pinacol ester 2-AMinopyriMidine-5-boronicacidpinacoleste 1H-PYRROL-3-OL,1-ETHYL-2-METHYL 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, 2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2-Aminopyrimidin-5-yl)boronic acid pinaco 2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-Aminopyrimidine-5-boronic Acid Pinacol Ester ISO 9001：2015 REACH 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine, 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine, 2-aminopyrimidine-5-boronic acid pinacol ester, 5-(4,4,5,5-tet CAS:402960-38-7 2-Aminopyrimidine-5-boronic acid pinacol ester - [A1748] 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 402960-38-7 40296-38-7 C10H16BN3O2 C10H18BN3O3 Heterocyclic Compounds Amino Organoborons Pyrimidine