Methyl 5-aminosalicylate
- CAS No.
- 42753-75-3
- Chemical Name:
- Methyl 5-aminosalicylate
- Synonyms
- METHYL 5-AMINO-2-HYDROXYBENZOATE;Mesalazine Methyl Ester;5-Aminomethylsalicylate;Methyl 5-aminosalicylate;5-aminomethylsalicylicacid;Methyl 5-aminosalicylate 97%;5-Aminosalicylic methyl ester;METHYL 5-AMINOMETHYLSALICYLATE;5-amino-salicylicacimethylester;5-AMINO SALICYLIC ACID METHYL ESTER
- CBNumber:
- CB5452161
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD01317557
- MOL File:
- 42753-75-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 95-99 °C (lit.) |
|---|---|
| Boiling point | 319.2±27.0 °C(Predicted) |
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.02±0.18(Predicted) |
| color | Pale Yellow to Brown |
| InChI | 1S/C8H9NO3/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,10H,9H2,1H3 |
| InChIKey | MXUHMQZOATZRIK-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(N)ccc1O |
| CAS DataBase Reference | 42753-75-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H317-H319-H335 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-43 |
| Safety Statements | 26 |
| WGK Germany | 2 |
| RTECS | VO1683100 |
| HazardClass | IRRITANT |
| HS Code | 2922500090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
Methyl 5-aminosalicylate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 636436 | Methyl 5-aminosalicylate 97% | 42753-75-3 | 1g | $51.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 636436 | Methyl 5-aminosalicylate 97% | 42753-75-3 | 5g | $161 | 2026-04-30 | Buy |
| TRC | TRC-A611285-5G | 5-Amino-2-hydroxybenzoic Acid Methyl Ester | 42753-75-3 | 5g | $223 | 2026-06-03 | Buy |
| TRC | TRC-A611285-25G | 5-Amino-2-hydroxybenzoic Acid Methyl Ester | 42753-75-3 | 25g | $1057 | 2026-06-03 | Buy |
| TRC | TRC-A611285-1G | 5-Amino-2-hydroxybenzoic Acid Methyl Ester | 42753-75-3 | 1g | $65 | 2026-06-03 | Buy |
Methyl 5-aminosalicylate Chemical Properties,Uses,Production
Uses
5-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
Synthesis
67-56-1
89-57-6
42753-75-3
In a 5-liter four-necked flask equipped with a reflux condenser, a dropping funnel, a thermometer casing, and a mechanical stirrer, methanol (3500 mL) and 5-aminosalicylic acid (500 g, 3.26 mol) were added and stirring was turned on. The reaction temperature was controlled in the range of 35-40 °C and thionyl chloride (600 mL, 8.16 mol) was added slowly dropwise for about 2 hours. After the dropwise addition, the reaction mixture was heated and refluxed for 15-16 hours, during which the reaction mixture gradually changed to a brown dilute slurry. The progress of the reaction was monitored by thin layer chromatography (TLC) until the residue of 5-aminosalicylic acid was below 1.0% (based on TLC analysis). Subsequently, the following post-treatment was carried out: first, about 2000 mL of methanol was removed by distillation at atmospheric pressure, and then the remaining methanol was azeotropically distilled (3 × 1000 mL) with water at reduced pressure (200-250 mmHg) to obtain a slurry. The slurry was poured into water (3500 mL) and the pH was adjusted first to 5.0 with 25% (w/v) NaOH solution (750 mL) and then to 7.0-7.5 with 20% (w/v) Na2CO3 solution (300 mL).The precipitated solid of methyl 5-amino salicylate was filtered and washed with water (2 x 1000 mL). The filter cake was dried to constant weight at 65 °C under reduced pressure (250 mmHg) to give 490 g of product in 90% yield. Melting point: 93-95°C. Reference: EP 0291159. 1H-NMR (CDCl3) data: δ 3.92 ppm (3H, s, Ar-COOCH3); 6.85 ppm (2H, m, Ar-H); 7.16 ppm (1H, d, J=2.73 Hz, Ar-H). Mass spectral data: m/z 167 (M+), 135, 107, 79.
References
[1] Journal of Organic Chemistry, 2011, vol. 76, # 15, p. 5873 - 5881
[2] Journal of Organic Chemistry, 2008, vol. 73, # 16, p. 6152 - 6157
[3] European Journal of Organic Chemistry, 2009, # 13, p. 2055 - 2058
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 189 - 192
[5] Patent: US2004/132982, 2004, A1. Location in patent: Page 4
Methyl 5-aminosalicylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from Methyl 5-aminosalicylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | METHYL 5-AMINOSALICYLATE
42753-75-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- METHYL 5-AMINOSALICYLATE
42753-75-3
- $1.00
- 99%
- Career Henan Chemical Co
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