6-FLUOROQUINOLINE-2-CARBOXALDEHYDE
- CAS No.
- 260430-93-1
- Chemical Name:
- 6-FLUOROQUINOLINE-2-CARBOXALDEHYDE
- Synonyms
- 6-FLUOROQUINOLINE-2-CARBALDEHYDE;6-Fluoro-2-quinolinecarboxaldehyde;6-FLUOROQUINOLINE-2-CARBOXALDEHYDE;6-Fluoroquinoline-2-carbaldehyde 97%;2-Quinolinecarboxaldehyde, 6-fluoro-;6-Fluoroquinoline-2-carboxaldehyde,97%;6-fluoroquinoline-2-carbaldehyde(SALTDATA: FREE);6-
Fluoroquinoline- 2- carboxaldehyde
- CBNumber:
- CB8721431
- Molecular Formula:
- C10H6FNO
- Molecular Weight:
- 175.16
- MDL Number:
- MFCD06751849
- MOL File:
- 260430-93-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Fluoroquinoline-2-carboxaldehyde 96% | 774480 | 1g | $71.06 |
| 6-fluoroquinoline-2-carbaldehyde | B440760 | 500mg | $350 |
| 6-Fluoroquinoline-2-carbaldehyde 95+% | 093671 | 250mg | $288 |
| 6-Fluoroquinoline-2-carbaldehyde 95+% | 093671 | 1g | $639 |
| 6-FLUOROQUINOLINE-2-CARBALDEHYDE 95.00% | HCH0089425 | 1G | $952.01 |
| More product size | |||
| Melting point | 113-120℃ |
|---|---|
| Boiling point | 318.0±22.0 °C(Predicted) |
| Density | 1.320±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Solid |
| pka | 2.98±0.43(Predicted) |
| Appearance | Light yellow to brown Solid |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C10H6FNO/c11-8-2-4-10-7(5-8)1-3-9(6-13)12-10/h1-6H |
| InChIKey | JDQMJKKGPXPPOJ-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(F)=CC=2)C=CC=1C=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933499090 | |||||||||
| NFPA 704 |
|
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 774480 | 6-Fluoroquinoline-2-carboxaldehyde 96% | 260430-93-1 | 1g | $71.06 | 2025-07-31 | Buy |
| TRC | B440760 | 6-fluoroquinoline-2-carbaldehyde | 260430-93-1 | 500mg | $350 | 2021-12-16 | Buy |
| Matrix Scientific | 093671 | 6-Fluoroquinoline-2-carbaldehyde 95+% | 260430-93-1 | 250mg | $288 | 2021-12-16 | Buy |
| Matrix Scientific | 093671 | 6-Fluoroquinoline-2-carbaldehyde 95+% | 260430-93-1 | 1g | $639 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0089425 | 6-FLUOROQUINOLINE-2-CARBALDEHYDE 95.00% | 260430-93-1 | 1G | $952.01 | 2021-12-16 | Buy |
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Chemical Properties,Uses,Production
Synthesis
1128-61-6
260430-93-1
General procedure for the synthesis of 6-fluoroquinoline-2-carbaldehyde from 6-fluoro-2-methylquinoline: a mixture of compound 6 (0.48 g, 3.0 mmol) with selenium dioxide (0.66 g, 6.0 mmol) in 1,4-dioxane (50 mL) was heated and reacted for 2 hr at 100 °C (the reaction progress was monitored by TLC). Upon completion of the reaction, the mixture was cooled and treated with 5% aqueous NaHCO3 (80 mL) followed by extraction with dichloromethane (50 mL x 3). The organic layers were combined and dried with anhydrous magnesium sulfate, followed by evaporation of the solvent. The crude product was crystallized by ethanol to give compound 7 (0.43 g, 81% yield) as a white solid. Next, compound 7 (0.36 g, 2.0 mmol) was stirred with the corresponding acetophenone (2.0 mmol) at 0 °C for 15 min. Six equivalents of aqueous KOH solution was added and the reaction mixture was stirred at room temperature for 12 hours (the progress of the reaction was monitored by TLC). After completion of the reaction, the reaction mixture was adjusted to pH 3 by adding 1 M HCl to the reaction mixture and extracted with ethyl acetate (50 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum. The crude products were obtained as quinolinyl chalcone derivatives 8a-c by purification and crystallization with ethanol.
References
[1] Heterocycles, 2000, vol. 53, # 1, p. 37 - 48
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8663 - 8678
[3] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 282 - 292
[4] Patent: TW2018/6938, 2018, A. Location in patent: Paragraph 0027; 0028
[5] Patent: CN106083713, 2016, A. Location in patent: Paragraph 0060-0062
6-FLUOROQUINOLINE-2-CARBOXALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16516 | 58 |
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