METHYSTICIN
- CAS No.
- 20697-20-5
- Chemical Name:
- METHYSTICIN
- Synonyms
- KAVATIN;KAVAHIN;metysticin;METHYSTICIN;(±)-Methysticin;(±)-Methystici);METHYSTICIN USP/EP/BP;Methysticin (DL-Methysticin;5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one;6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
- CBNumber:
- CB5456785
- Molecular Formula:
- C15H14O5
- Molecular Weight:
- 274.27
- MDL Number:
- MFCD00221732
- MOL File:
- 20697-20-5.mol
- MSDS File:
- SDS
| Melting point | 129-131 °C |
|---|---|
| Boiling point | 496.5±45.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| FDA UNII | M832AIJ6HX |
METHYSTICIN price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VAA69720 | DL-Methysticin | 20697-20-5 | 5mg | $900 | 2026-06-05 | Buy |
| Biosynth | VAA69720 | DL-Methysticin | 20697-20-5 | 2mg | $900 | 2026-06-05 | Buy |
| Biosynth | VAA69720 | DL-Methysticin | 20697-20-5 | 1mg | $900 | 2026-06-05 | Buy |
| Biosynth | VAA69720 | DL-Methysticin | 20697-20-5 | 10mg | $900 | 2026-06-05 | Buy |
| Biosynth | VAA69720 | DL-Methysticin | 20697-20-5 | 0.5mg | $900 | 2026-06-05 | Buy |
METHYSTICIN Chemical Properties,Uses,Production
Uses
DL-Methysticin is a useful synthetic compound.
in vivo
The kavalactone Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6 month old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in a significant activation of the Nrf2/ARE pathway in hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals[2].
IC 50
CYP1A1
METHYSTICIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Shanghai BeiZhuo Biotech Co., Ltd. | 021-61119791,13386096464 | bzswkf@foxmail.com | China | 3916 | 50 |
| Shanghai Zhanshu Chemical Technology Co., Ltd | +86-21-58589556 | China | 413 | 55 | |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2992 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai ChengShao Biological Technology Co., Ltd. | 021-61847300 13341622919 | shcss01@163.com | China | 4806 | 58 |
