Kavain
- CAS No.
- 3155-48-4
- Chemical Name:
- Kavain
- Synonyms
- rac-Kavain;KAWAIN;Kavain;DL-KAWAIN;DL-KAVAIN;(+)-KAVAIN;(±)-Kavain;Kawain, DL-;KAVAIN, DL-;METHYSTICIN(P)
- CBNumber:
- CB9738874
- Molecular Formula:
- C14H14O3
- Molecular Weight:
- 230.26
- MDL Number:
- MFCD00270446
- MOL File:
- 3155-48-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142-148 °C |
|---|---|
| Boiling point | 432.6±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Off-White to Pale Yellow |
| BRN | 177877 |
| Stability | Light and Moisture Sensitive |
| Major Application | food and beverages |
| InChI | InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+ |
| InChIKey | XEAQIWGXBXCYFX-BQYQJAHWSA-N |
| SMILES | C1(=O)OC(/C=C/C2=CC=CC=C2)CC(OC)=C1 |
| LogP | 1.690 (est) |
| CAS DataBase Reference | 3155-48-4(CAS DataBase Reference) |
| FDA UNII | 5L1NI60TGB |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| F | 10-23 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Kavain price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39921 | (±)-Kavain ≥98% | 3155-48-4 | 1mg | $70 | 2026-04-30 | Buy |
| Cayman Chemical | 41213 | (±)-Kavain (CRM) | 3155-48-4 | 1mg | $142 | 2026-04-30 | Buy |
| Cayman Chemical | 39921 | (±)-Kavain ≥98% | 3155-48-4 | 5mg | $278 | 2026-04-30 | Buy |
| Biosynth | FK65645 | DL-Kawain | 3155-48-4 | 0.1g | $480.41 | 2026-06-04 | Buy |
| Biosynth | FK65645 | DL-Kawain | 3155-48-4 | 0.25g | $768.65 | 2026-06-04 | Buy |
Kavain Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Kava Piper methysticum.
Uses
anticonvulsant, analgesic, anxiolytic, suppreses excitatory postsynaptic potential
Uses
rac-Kavain is the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.
Definition
ChEBI: DL-kavain is https://www.chemicalbook.com/ProductChemicalPropertiesCB9738874_EN.htm It has a role as a glycine receptor antagonist.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 4070, 1976 DOI: 10.1021/jo00888a004
Synthesis
A method for isolation and purification of Kavain, the method comprising the steps of: (1) Pre-treatment of raw herbs: take Cava pepper and dry it at low temperature, and pulverize it into coarse powder; (2) Supercritical extraction: put the crude powder of medicinal herbs into the extraction kettle for extraction, the extraction conditions are: pressure 18-30MPa, temperature 30-45 , time for 2-4 hours, and then the pressure is 4-8MPa, temperature 40-50 under the resolution; (3) Column chromatography: take out the extract, heat water dispersion and add the macroporous adsorbent resin column adsorption, flow rate of 1-3BV/h, first 3 times the volume of the column 30% ethanol elution, and then 5 times the volume of the column of 50% -80% ethanol elution, collection of 50% -80% ethanol eluent; (4) decolorization: the eluent is added with activated carbon, the amount added is 1-5% of the volume of the eluent; (5) crystallization: decolorized liquid concentrated under reduced pressure precipitation crystal, crude crystal and then ethanol - ethyl acetate (1:1) heating to dissolve, refrigerated crystals, crystals drying drunken pepper pigment.
Kavain Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
| Cato Research Chemicals Inc. | 020-81960175-877 18933936954 | tianwen.zhan@cato-chem.com | China | 7335 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Shanghai CoachChem Co., Ltd. | +86-21-67299971；+86-21-67290723 18117322963 | marketing@coachchem.com | China | 96 | 62 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 4094 | 50 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
