ChemicalBook >> CAS DataBase List >>2,2-Difluorobenzodioxole-5-carboxylic acid
2,2-Difluorobenzodioxole-5-carboxylic acid
- CAS No.
- 656-46-2
- Chemical Name:
- 2,2-Difluorobenzodioxole-5-carboxylic acid
- Synonyms
- 2,2-DIFLUORO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID;BUTTPARK 29\01-69;RARECHEM AL BO 0906;2,2-Difluoro-1,3-benzodioxole-5-ca;5-Carboxy-2,2-difluoro-1,3-benzodioxole;2,2-Difluorobenzodioxole-5-carboxylic acid;2,2-difuoro-[1,3]-benzodioxole-5-carboxy acid;2,3-Difluoro-1,3-benzodioxole-5-carboxylic acid;1,3-Benzodioxole-5-carboxylicacid, 2,2-difluoro-;2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid98%
- CBNumber:
- CB5457823
- Molecular Formula:
- C8H4F2O4
- Molecular Weight:
- 202.11
- MDL Number:
- MFCD00792417
- MOL File:
- 656-46-2.mol
- MSDS File:
- SDS
Last updated:2026-05-28 01:14:53
| Melting point | 178 |
|---|---|
| Boiling point | 266.1±40.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.01±0.40(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 656-46-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2932990090 | |||||||||
| NFPA 704 |
|
2,2-Difluorobenzodioxole-5-carboxylic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D445583-100MG | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid | 656-46-2 | 100mg | $63 | 2026-06-03 | Buy |
| Apolloscientific | PC4367 | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid 98% | 656-46-2 | 250mg | $21 | 2026-06-04 | Buy |
| Matrix Scientific | 082774 | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid | 656-46-2 | 1.00g | $120 | 2026-05-18 | Buy |
| Matrix Scientific | 082774 | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid | 656-46-2 | 10.00g | $840 | 2026-05-18 | Buy |
| Synthonix | D12630 | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid 95+% | 656-46-2 | 1g | $14 | 2026-05-06 | Buy |
2,2-Difluorobenzodioxole-5-carboxylic acid Chemical Properties, Uses, Production
Synthesis
![methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate](/CAS/GIF/773873-95-3.gif)
773873-95-3
656-46-2
The general procedure for the synthesis of 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid from methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate is as follows: Step 2. A solution of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate (1.4 g, 6.48 mmol) and sodium hydroxide (830 mg, 20.75 mmol) in methanol (30 ml) was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated under vacuum and subsequently dissolved in water (20 ml). The pH of the aqueous solution was adjusted to 3 with 3N HCl, at which point a precipitate was produced. The precipitate was collected by filtration to afford 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylic acid as a white solid (1.2 g, 92% yield). Product characterization data: 1H-NMR (300 MHz, DMSO) δ 13.23 (s, 1H, COOH), 7.85 (s, 1H, Ar-H), 7.53 (d, J=1.5 Hz, 1H, Ar-H), 7.53 (d, J=9.0 Hz, 1H, Ar-H).
References
[1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 26
2,2-Difluorobenzodioxole-5-carboxylic acid Preparation Products And Raw materials
Global Suppliers ( 176)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
View Latest Price from 2,2-Difluorobenzodioxole-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,2-Difluorobenzodioxole-5-carboxylic acid
656-46-2
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2,2-Difluorobenzodioxole-5-carboxylic acid
656-46-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2022-02-19 | 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid
656-46-2
|
1KG | 99.4% | 100 tons | Honest Joy Holdings Limited |
-
- 2,2-Difluorobenzodioxole-5-carboxylic acid
656-46-2
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,2-Difluorobenzodioxole-5-carboxylic acid
656-46-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid
656-46-2
- $0.00
- 99.4%
- Honest Joy Holdings Limited
656-46-2 (2,2-Difluorobenzodioxole-5-carboxylic acid) Related Search:
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1of4
BUTTPARK 29\01-69
RARECHEM AL BO 0906
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid, 97+%
5-Carboxy-2,2-difluoro-1,3-benzodioxole
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid 98%
2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid98%
2,3-Difluoro-1,3-benzodioxole-5-carboxylic acid
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1,3-Benzodioxole-5-carboxylicacid, 2,2-difluoro-
2,2-difuoro-[1,3]-benzodioxole-5-carboxy acid
2,2-Difluoro-1,3-benzodioxole-5-ca
2,2-Difluoro6benzo[d][1,3]dioxole-5-carboxylic acid
2,2-DIFLUORO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID
656-46-2
C8H3F2O4
Benzodiozoles, Benzodioxines & Benzodioxepines
Carboxylic Acids
Heterocycles series
Benzodiozoles, Benzodioxines & Benzodioxepines
Carboxylic Acids
