Praliciguat
- CAS No.
- 1628730-49-3
- Chemical Name:
- Praliciguat
- Synonyms
- IW-1973;Praliciguat;Praliciguat, 10 mM in DMSO;Praliciguat,IW 1973,Guanylate Cyclase,Inhibitor,IW1973,inhibit;2-Propanol, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-
- CBNumber:
- CB54668407
- Molecular Formula:
- C21H14F8N6O2
- Molecular Weight:
- 534.36
- MDL Number:
- MFCD32062661
- MOL File:
- 1628730-49-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 588.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.60±0.1 g/cm3(Predicted) |
| solubility | DMSO : 250 mg/mL (467.85 mM; Need ultrasonic) |
| pka | 8.99±0.29(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | R1S0H458SA |
Praliciguat price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BP177758 | Praliciguat | 1628730-49-3 | 1mg | $499.73 | 2026-06-04 | Buy |
| Biosynth | BP177758 | Praliciguat | 1628730-49-3 | 2mg | $713.9 | 2026-06-04 | Buy |
| Biosynth | BP177758 | Praliciguat | 1628730-49-3 | 5mg | $1285 | 2026-06-04 | Buy |
| Biosynth | BP177758 | Praliciguat | 1628730-49-3 | 10mg | $1998.9 | 2026-06-04 | Buy |
| Biosynth | BP177758 | Praliciguat | 1628730-49-3 | 25mg | $3141.25 | 2026-06-04 | Buy |
Praliciguat Chemical Properties, Uses, Production
Uses
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM[1].
Definition
ChEBI: Praliciguat is a member of the class of pyrazoles that is 5-fluoro-2-(1H-pyrazol-3-yl)pyrimidine which is substituted by a 2-fluorobenzyl group at position 1, 1,2-oxazol-3-yl group at position 5, and by a [3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]nitrilo group at position 4. It is a soluble guanylate cyclase stimulator under clinical development for the treatment of heart failure with preserved ejection fraction. It has a role as a soluble guanylate cyclase activator, an anti-inflammatory agent, a vasodilator agent and an antihypertensive agent. It is a member of isoxazoles, a member of pyrazoles, an organofluorine compound, an aminopyrimidine, a tertiary alcohol, a secondary amino compound and a member of monofluorobenzenes.
References
[1] Daniel P Zimmer, et al. Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution.
Praliciguat Preparation Products And Raw materials
Raw materials
Preparation Products
Praliciguat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 5019 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 618 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Wuhan Topule | +86-02787215551 19945035818 | 2936752263@qq.com | China | 7983 | 58 |
View Latest Price from Praliciguat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Praliciguat
1628730-49-3
|
$153.00-387.00 | 99.05% | 10g | TargetMol Chemicals Inc. |
-
- Praliciguat
1628730-49-3
- $153.00-387.00
- 99.05%
- TargetMol Chemicals Inc.
