9-Fluorenol
- CAS No.
- 1689-64-1
- Chemical Name:
- 9-Fluorenol
- Synonyms
- hydrafinil;9h-fluoren-9-ol;9-HYDROXYFLUORENE;uorenoL;Hydranafil;1689-64- 1;9-FLUORENOL;fluoren-9-ol;Hydroxyfluoren;9-Fluorenol>
- CBNumber:
- CB5476145
- Molecular Formula:
- C13H10O
- Molecular Weight:
- 182.22
- MDL Number:
- MFCD00001135
- MOL File:
- 1689-64-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 153-154 °C(lit.) |
|---|---|
| Boiling point | 275.62°C (rough estimate) |
| Density | 1.0368 (rough estimate) |
| refractive index | 1.5994 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 13.34±0.20(Predicted) |
| form | Crystalline Powder |
| color | Cream |
| Water Solubility | Insoluble in water. |
| BRN | 1869799 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C13H10O/c14-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)13/h1-8,13-14H |
| InChIKey | AFMVESZOYKHDBJ-UHFFFAOYSA-N |
| SMILES | OC1c2ccccc2-c3ccccc13 |
| CAS DataBase Reference | 1689-64-1(CAS DataBase Reference) |
| FDA UNII | BV0Q72R613 |
| NIST Chemistry Reference | 9H-fluoren-9-ol(1689-64-1) |
| EPA Substance Registry System | 9-Hydroxyfluorene (1689-64-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H411 | |||||||||
| Precautionary statements | P501-P273-P391 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36/37/39-27-26 | |||||||||
| RIDADR | UN 3077 9/PG III | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29062990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| NFPA 704 |
|
9-Fluorenol price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H31204 | 9-Hydroxyfluorene 96% | 1689-64-1 | 5g | $61.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | H31204 | 9-Hydroxyfluorene 96% | 1689-64-1 | 25g | $111 | 2026-04-30 | Buy |
| TCI Chemical | F0229 | 9-Fluorenol >99.0%(GC) | 1689-64-1 | 25g | $156 | 2026-04-30 | Buy |
| TCI Chemical | F0229 | 9-Fluorenol >99.0%(GC) | 1689-64-1 | 250g | $890 | 2026-04-30 | Buy |
| Cayman Chemical | 19799 | Fluorenol ≥98% | 1689-64-1 | 1mg | $49 | 2026-04-30 | Buy |
9-Fluorenol Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
9-Fluorenol is used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.
Application
9-Fluorenol is a wake-promoting agent and is considered a next-generation anti-drowsiness drug. It is also a potential environmental carcinogen.
9-Fluorenol is a dopamine reuptake inhibitor with IC50 of 9 μM, and a major metabolite of a compound developed as a wakefulness-promoting agent.
Preparation
Synthesis of 9-Fluorenol: A 5-g sample of 9-fluorenone is dissolved in 30 mL of warm ethanol in a 100-mL beaker. To this solution is added, dropwise, 10 mL of a reducing reagent, freshly prepared, which consists of 200 mg sodium methoxide,10 mL methanol, and 0.4 g sodium borohydride.This solution is allowed to stand undisturbed for 10-20 min. A color change is observed as the reaction proceeds from the yellow 9-fluorenone to the white 9-fluorenol.The product is precipitated by the addition of 50 mL of water and neutralized with 0.1 M HCl, vacuum filtered, and washed with cold water to remove any residual inorganic salt formed by the excess of the sodium borohydride reagent and hydrochloric acid.The dried crude product is sufficiently pure for characterization by melting point, infrared spectra,and NMR.The crude product melting point is 153°C, with a product yield of 95-100%.
A Synthesis of 9-Fluorenol: Sodium Borohydride Reduction of 9-Fluorenone
Definition
ChEBI: 9-Fluorenol is a member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon). It has a role as an animal metabolite. It is a member of hydroxyfluorenes and a secondary alcohol.
Synthesis Reference(s)
The Journal of Organic Chemistry, 57, p. 6313, 1992 DOI: 10.1021/jo00049a045
Tetrahedron Letters, 13, p. 343, 1972
Synthesis
9-Fluorenol is prepared by reacting 9-fluorenone with THF solution of phosphazene under the action of boron catalyst.Add
9-fluorenone (0.8 mmol), a 0.2 M THF solution of phosphazene (80 μL,
0.016 mmol) and a 0.0762 M THF solution of boron catalyst (420 μL, 0.032
mmol) to a scintillation vial with magnetic stir bar in a glove box.
Place the scintillation vial in a Parr reactor. Seal the reactor.
Pressurize the reactor with hydrogen gas. Heat reaction mixture at 75°C
(inside the reactor). Stir the reaction mixture (1000 rpm) for 20 hours
at 75°C. Cool the mixture to room temperature and vent the Parr reactor
to obtain 9-hydroxyfluoren. Analyze the reaction mixture by 1H NMR spectroscopy using CDCl3 as solvent.
Fig the synthetic method of 9-Fluorenol
9-Fluorenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Puyang Huicheng Electronic Material Co. Ltd. | 0393-0393-8910800 15039333257 | info@huichengchem.com | China | 588 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
Related articles
- 9-Fluorenol: Properties and Functional Applications
- 9-fluorenol thermodynamic parameters have been determined, and it acts as a mild metal-free organocatalyst for aryl halide deh....
- Apr 25,2026
- Synthesis and Thermodynamic property of 9-Fluorenol
- 9-Fluorenol, a wakefulness stimulant, is considered to be the next generation of anti-lethargy drugs.
- Oct 26,2022
View Lastest Price from 9-Fluorenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 9-fluorenol
1689-64-1
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-25 | 9-Fluorenol
1689-64-1
|
1kg | 99 | 200 | Xi an Biohorlden Industry Trade Co Ltd | ||
 |
2026-03-20 | 9-FLUORENOL
1689-64-1
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 9-fluorenol
1689-64-1
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 9-Fluorenol
1689-64-1
- $0.00
- 99
- Xi an Biohorlden Industry Trade Co Ltd
-
- 9-FLUORENOL
1689-64-1
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
1689-64-1(9-Fluorenol)Related Search:
1of4
