(4-Methoxybenzyloxy)acetic acid
- CAS No.
- 88920-24-5
- Chemical Name:
- (4-Methoxybenzyloxy)acetic acid
- Synonyms
- p-methoxybenzyloxy acetic acid;2-((4-Methoxybenzyl)oxy)acetic acid;(4-METHOXYBENZYLOXY)ACETIC ACID;Acetic acid, 2-[(4-methoxyphenyl)methoxy]-
- CBNumber:
- CB5479595
- Molecular Formula:
- C10H12O4
- Molecular Weight:
- 196.2
- MDL Number:
- MFCD01861881
- MOL File:
- 88920-24-5.mol
- MSDS File:
- SDS
| Melting point | 50.8-51.8 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
|---|---|
| Boiling point | 367.4±22.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.40±0.10(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918999090 |
(4-Methoxybenzyloxy)acetic acid price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M331513-50MG | 2-((4-Methoxybenzyl)oxy)acetic Acid | 88920-24-5 | 50mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-M331513-500MG | 2-((4-Methoxybenzyl)oxy)acetic Acid | 88920-24-5 | 500mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-M331513-100MG | 2-((4-Methoxybenzyl)oxy)acetic Acid | 88920-24-5 | 100mg | $78 | 2026-06-03 | Buy |
| Apolloscientific | OR939102 | 2-((4-Methoxybenzyl)oxy)acetic acid 98% | 88920-24-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR939102 | 2-((4-Methoxybenzyl)oxy)acetic acid 98% | 88920-24-5 | 5g | $71 | 2026-06-04 | Buy |
(4-Methoxybenzyloxy)acetic acid Chemical Properties, Uses, Production
Synthesis
79-08-3
105-13-5
88920-24-5
4-Methoxybenzyl alcohol (1 eq.) and bromoacetic acid (1.2 eq.) were dissolved in anhydrous tetrahydrofuran at 0 °C. Sodium hydride (60% w/w, mineral oil dispersion, 3 eq.) was added in three batches. The reaction mixture was stirred at 70 °C for 4 hours. After cooling to room temperature, water was added and the resulting mixture was washed with hexane. The aqueous phase was acidified to pH 2 with 1N hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by silica gel column chromatography with hexane solution of 50% ethyl acetate as eluent gave (4-methoxybenzyloxy)acetic acid (0.51 g, 71% yield) as a colorless solid.1H NMR (500 MHz, CDCl3) δ 7.29 (m, 2H), 6.90 (m, 2H), 4.59 (s, 2H), 4.10 (s, 2H), 3.81 ( s, 3H).
References
[1] Bioorganic and medicinal chemistry letters, 2001, vol. 11, # 21, p. 2837 - 2841
[2] Synlett, 2012, vol. 23, # 19, p. 2845 - 2849
[3] Tetrahedron Letters, 2002, vol. 43, # 41, p. 7427 - 7429
[4] Patent: WO2014/144100, 2014, A2. Location in patent: Paragraph 00274
[5] Patent: WO2006/109729, 2006, A1. Location in patent: Page/Page column 138-139
(4-Methoxybenzyloxy)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Methoxybenzyloxy)acetic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
