DC1-SMe
- CAS No.
- 501666-85-9
- Chemical Name:
- DC1-SMe
- Synonyms
- DC1-SMe;DC1SMe,DC-1SMe;1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-
- CBNumber:
- CB54797044
- Molecular Formula:
- C35H30ClN5O4S2
- Molecular Weight:
- 684.23
- MDL Number:
- MFCD31746905
- MOL File:
- 501666-85-9.mol
| Product description | Number | Pack Size | Price |
| DC1SMe >98.0% | CS-0067641 | 5mg | $550 |
| DC1SMe >98.0% | CS-0067641 | 10mg | $850 |
| DC1SMe >98.0% | CS-0067641 | 25mg | $1750 |
| DC1SMe >98.0% | CS-0067641 | 50mg | $3150 |
| DC1SMe >98.0% | CS-0067641 | 100mg | $5700 |
DC1-SMe price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0067641 | DC1SMe >98.0% | 501666-85-9 | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0067641 | DC1SMe >98.0% | 501666-85-9 | 10mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0067641 | DC1SMe >98.0% | 501666-85-9 | 25mg | $1750 | 2021-12-16 | Buy |
| ChemScene | CS-0067641 | DC1SMe >98.0% | 501666-85-9 | 50mg | $3150 | 2021-12-16 | Buy |
| ChemScene | CS-0067641 | DC1SMe >98.0% | 501666-85-9 | 100mg | $5700 | 2021-12-16 | Buy |
DC1-SMe Chemical Properties,Uses,Production
Uses
DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
IC 50
Duocarmycins
References
[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m
DC1-SMe Preparation Products And Raw materials
DC1-SMe Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 787 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 820 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
