IDH1 Inhibitor 1
- CAS No.
- 2234285-81-3
- Chemical Name:
- IDH1 Inhibitor 1
- Synonyms
- IDH1 Inhibitor 1;IDH-1 Inhibitor 1,IDH1 Inhibitor 1;2-Oxazolidinone, 4-(fluoromethyl)-3-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]-1H-imidazol-4-yl]ethyl]amino]-4-pyrimidinyl]-, (4R)-
- CBNumber:
- CB54844890
- Molecular Formula:
- C20H18F4N6O2
- Molecular Weight:
- 450.39
- MDL Number:
- MFCD31813679
- MOL File:
- 2234285-81-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
IDH1 Inhibitor 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0047685 | IDH1 Inhibitor 1 99.96% | 2234285-81-3 | 5mg | $845 | 2026-06-04 | Buy |
| ChemScene | CS-0047685 | IDH1 Inhibitor 1 99.96% | 2234285-81-3 | 10mg | $1354 | 2026-06-04 | Buy |
| ChemScene | CS-0047685 | IDH1 Inhibitor 1 99.96% | 2234285-81-3 | 25mg | $2795 | 2026-06-04 | Buy |
| ChemScene | CS-0047685 | IDH1 Inhibitor 1 99.96% | 2234285-81-3 | 50mg | $3792 | 2026-06-04 | Buy |
| ChemScene | CS-0047685 | IDH1 Inhibitor 1 99.96% | 2234285-81-3 | 100mg | $5178 | 2026-06-04 | Buy |
IDH1 Inhibitor 1 Chemical Properties, Uses, Production
Uses
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively[1]. Anticancer activity[1].
in vivo
IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production[1].
References
[1] Zhao Q, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors. ACS Med Chem Lett. 2018 Jun 11;9(7):746-751. DOI:10.1021/acsmedchemlett.8b00182
IDH1 Inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
IDH1 Inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
