(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
![(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Structure](CAS/GIF/60-99-1.gif)
- CAS No.
- 60-99-1
- Chemical Name:
- (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
- Synonyms
- Levomepromazine;methotrimeprazine;Levotomin;Levopromazine;Levomepromazin;XP 03;rp7044;C07192;Nirvan;skf5116
- CBNumber:
- CB5488571
- Molecular Formula:
- C19H24N2OS
- Molecular Weight:
- 328.47
- MDL Number:
- MFCD00869255
- MOL File:
- 60-99-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methotrimeprazine maleate salt | 1415006 | 200mg | $498 |
| (R)-Methotrimeprazine | TRC-M260770-1MG | 1mg | $278 |
| (R)-Methotrimeprazine | TRC-M260770-10MG | 10mg | $2063 |
| Methotrimeprazine | FM165717 | 5mg | $900 |
| Methotrimeprazine | FM165717 | 50mg | $900 |
| More product size | |||
| Melting point | 117°C |
|---|---|
| Boiling point | 468.0±45.0 °C(Predicted) |
| Density | 1.0897 (rough estimate) |
| refractive index | 1.5950 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Chloroform (Slightly), Methanol (Very Slightly) |
| pka | 9.32±0.28(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 20mg/L(25 ºC) |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1 |
| InChIKey | VRQVVMDWGGWHTJ-CQSZACIVSA-N |
| SMILES | S1c2c(cc(cc2)OC)N(c3c1cccc3)C[C@@H](CN(C)C)C |
| FDA UNII | 9G0LAW7ATQ |
| ATC code | N05AA02 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P280-P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36 |
| RIDADR | 3249 |
| WGK Germany | WGK 3 |
| RTECS | SO6125000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2934302300 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
| Toxicity | LD50 oral in rat: 1100mg/kg |
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1415006 | Methotrimeprazine maleate salt | 60-99-1 | 200mg | $498 | 2026-04-30 | Buy |
| TRC | TRC-M260770-1MG | (R)-Methotrimeprazine | 60-99-1 | 1mg | $278 | 2026-06-03 | Buy |
| TRC | TRC-M260770-10MG | (R)-Methotrimeprazine | 60-99-1 | 10mg | $2063 | 2026-06-03 | Buy |
| Biosynth | FM165717 | Methotrimeprazine | 60-99-1 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FM165717 | Methotrimeprazine | 60-99-1 | 50mg | $900 | 2026-06-04 | Buy |
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Uses,Production
Originator
Levoprome ,Lederle,US,1966
Uses
(R)-Methotrimeprazine acts as an analgesic agent.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.
Manufacturing Process
95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1 hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.
brand name
Levoprome (Immunex).
Therapeutic Function
Analgesic
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 283 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15080 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712779 +8617792793228 | 1069@dideu.com | China | 8662 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49952 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
View Lastest Price from (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Levomepromazine
60-99-1
|
$30.00 | 99.15% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-01-18 | Levomepromazine
60-99-1
|
$66.00 | 1kg | 99.98% | 1 | Xiamen Wonderful Bio Technology Co., Ltd. |
-
- Levomepromazine
60-99-1
- $30.00
- 99.15%
- TargetMol Chemicals Inc.
-
- Levomepromazine
60-99-1
- $66.00
- 99.98%
- Xiamen Wonderful Bio Technology Co., Ltd.
