Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Structure
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide structure
CAS No.
1776116-74-5
Chemical Name:
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
Synonyms
MC 1742;MC1742,MC-1742;5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide;5-((4-([1,1'-Biphenyl]-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-hydroxypentanamide;Pentanamide, 5-[(4-[1,1'-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-
CBNumber:
CB54902828
Molecular Formula:
C21H21N3O3S
Molecular Weight:
395.47
MDL Number:
MFCD30290158
MOL File:
1776116-74-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
MC1742 ≥98% (HPLC) SML2862 5 mg $123.25
MC1742 ≥98% (HPLC) SML2862 25 mg $395.25
MC1742 ≥98% 29171 1mg $169
MC1742 ≥98% 29171 5mg $587
MC1742 ≥98% 29171 10mg $1003
Request For Quotation

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Properties

Density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 100 mM
form A solid
pka 7.51±0.50(Predicted)
color White to off-white
InChI 1S/C21H21N3O3S/c25-19(24-27)8-4-5-13-28-21-22-18(14-20(26)23-21)17-11-9-16(10-12-17)15-6-2-1-3-7-15/h1-3,6-7,9-12,14,27H,4-5,8,13H2,(H,24,25)(H,22,23,26)
InChIKey AOFVDNFTELWRHV-UHFFFAOYSA-N
SMILES S(CCCCC(=O)NO)c1[nH][c](cc(n1)c2ccc(cc2)c3ccccc3)=O
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2862 MC1742 ≥98% (HPLC) 1776116-74-5 5 mg $123.25 2026-04-30 Buy
Sigma-Aldrich SML2862 MC1742 ≥98% (HPLC) 1776116-74-5 25 mg $395.25 2026-04-30 Buy
Cayman Chemical 29171 MC1742 ≥98% 1776116-74-5 1mg $169 2026-04-30 Buy
Cayman Chemical 29171 MC1742 ≥98% 1776116-74-5 5mg $587 2026-04-30 Buy
Cayman Chemical 29171 MC1742 ≥98% 1776116-74-5 10mg $1003 2026-04-30 Buy
Product number Packaging Price Buy
SML2862 5 mg $123.25 Buy
SML2862 25 mg $395.25 Buy
29171 1mg $169 Buy
29171 5mg $587 Buy
29171 10mg $1003 Buy

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Chemical Properties,Uses,Production

Uses

MC 1742 is a novel histone deacetylase inhibitor, which has been shown to induce growth arrest, apoptosis and differentiation in sarcoma cancer stem cells.

Biological Activity

MC1742 is a uracil-based hydroxyamide (UBHA) th at acts as a subtype-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 100/110/20/610 nM, class IIB HDAC6/10 = 7/40 nM, class IV HDAC11 = 100 nM, class IIA HDAC4/5/7/9 >50 μM). MC1742 exerts greater antiproliferation potency than SAHA in sarcoma cancer stem cell (CSC) cultures (MC1742/SAHA IC50 in μM = 0.25/1/RD, 1.12/1.13//MG-63, 1.4/3.92/SK-ES-1 post 72-hr treatment) and effectively reactivates HIV from latency (EC50 = 350 nM; JL at 10.6 cells) by upregulating histone acetylation at the HIV promoter without activating T cells.

IC 50

HDAC1: 0.1 μM (IC50); HDAC2: 0.11 μM (IC50); HDAC3: 0.02 μM (IC50); HDAC6: 0.007 μM (IC50); HDAC8: 0.61 μM (IC50); HDAC10: 0.04 μM (IC50); HDAC11: 0.1 μM (IC50)

storage

Store at -20°C

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39037 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4865 55
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2983 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9642 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4061 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2223443625@qq.com China 7997 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Hongye Biotechnology Co. Ltd 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Hubei Kele Fine Chemical Co., Ltd 58

View Lastest Price from 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MC1742 pictures 2026-07-16 MC1742
1776116-74-5
 $149.00 99.20% 10g TargetMol Chemicals Inc.
  • MC1742 pictures
  • MC1742
    1776116-74-5
  • $149.00
  • 99.20%
  • TargetMol Chemicals Inc.
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide MC 1742 Pentanamide, 5-[(4-[1,1'-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy- MC1742,MC-1742 5-((4-([1,1'-Biphenyl]-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-hydroxypentanamide 1776116-74-5