ERYTHROMYCIN LACTOBIONATE (200 MG)
- CAS No.
- 3847-29-8
- Chemical Name:
- ERYTHROMYCIN LACTOBIONATE (200 MG)
- Synonyms
- Erythromycin lactobionate;Azithromycin lactobionate;Erythrocin lactobionate;ERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD);Lactose azithroMycin;C37H67NO13.C12H22O12;Erythomycin lactobionate;Moxifloxacin Impurity 146;Erythromycin iactobionate;Erythromycin lactobionate CRS
- CBNumber:
- CB5501658
- Molecular Formula:
- C37H67NO13.C12H22O12
- Molecular Weight:
- 1092.22
- MDL Number:
- MOL File:
- 3847-29-8.mol
- MSDS File:
- SDS
| Melting point | 145-150° |
|---|---|
| Density | 0.9083 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Refrigerator |
| solubility | Soluble in water, freely soluble in anhydrous ethanol and in methanol, very slightly soluble in acetone and in methylene chloride. |
| form | Solid |
| color | White to Off-White |
| Water Solubility | >20g/L(21 ºC) |
| Major Application |
USP Biologics pharmaceutical (small molecule) |
| InChIKey | NNRXCKZMQLFUPL-FACXKIDONA-N |
| FDA UNII | 33H58I7GLQ |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| HS Code | 2941500000 |
| Storage Class | 11 - Combustible Solids |
ERYTHROMYCIN LACTOBIONATE (200 MG) price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17189 | Erythromycin lactobionate | 3847-29-8 | 500mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17189 | Erythromycin lactobionate | 3847-29-8 | 1g | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 17189 | Erythromycin lactobionate | 3847-29-8 | 5g | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 17189 | Erythromycin lactobionate | 3847-29-8 | 10g | $469 | 2026-04-30 | Buy |
| Usbiological | 275559 | Erythromycin Lactobionate | 3847-29-8 | 500mg | $292 | 2026-06-03 | Buy |
ERYTHROMYCIN LACTOBIONATE (200 MG) Chemical Properties, Uses, Production
Description
Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications. Erythromycin lactobionate is a soluble salt of erythromycin that is typically used for intraperitoneal or intravenous injections.
Chemical Properties
White or slightly yellow hygroscopic, powder.
Originator
Erythrocin,Abbott,US,1954
Uses
Erythromycin Lactobionate is an antibiotic used to reduce the prevalence of drug resistant bacteria as well as keeping constant the efficacy of other antibacterial drugs.
Uses
Macrolide antibacterial.
Manufacturing Process
A solution of erythromycin free base is prepared by dissolving 8.0 grams of erythromycin in 25 cc of acetone. 4.0 grams of lactobiono-delta-lactone is dissolved in 25 cc of water. The free lactobionic acid is formed in this solution and it has the molecular formula C12H22O12. The two solutions are mixed and evaporated to a gummy residue. This residue is dissolved in 60 cc of water and the solution is frozen and dried in vacuum by lyophilization. The dried residue of erythromycin lactobionate is a white amorphous powder and weighs 11.7 grams. The reaction product has an activity against B. subtilis of 420units per milligram. Its solubility in water is about 200 mg/cc and the melting point of the white powdery reaction product is 145° to 150°C.
brand name
Erythrocin (Abbott); Erythrocin (Hospira).
Therapeutic Function
Antibacterial
General Description
Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.
References
[1] P PERITI. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I).[J]. Clinical Pharmacokinetics, 1989, 16 4: 193-214. DOI: 10.2165/00003088-198916040-00001
[2] G. LEBEK G T. Effects in vitro of erythromycin, alone and in combination with penicillin, on staphylococci, pneumococci and streptococci[J]. Current Medical Research and Opinion, 1978, 5 1: 3-14. DOI: 10.1185/03007997809110242
[3] E AZOULAY-DUPUIS. Antipneumococcal activity of ciprofloxacin, ofloxacin, and temafloxacin in an experimental mouse pneumonia model at various stages of the disease.[J]. Journal of Infectious Diseases, 1991, 163 2: 319-324. DOI: 10.1093/infdis/163.2.319
[4] Y HIRAKATA. Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.[J]. Antimicrobial Agents and Chemotherapy, 1992, 36 6: 1198-1203. DOI: 10.1128/aac.36.6.1198
ERYTHROMYCIN LACTOBIONATE (200 MG) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hainan Ling Chemical Pharmaceutical Co., Ltd. | -- | webmaster@hailingpharm.com | China | 9 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2696 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Guangzhou Ciming Biological Technology Co., Ltd. | 020-38082199,29065168,38082986,29878298,29866629,4000192398 | China | 826 | 60 |
View Latest Price from ERYTHROMYCIN LACTOBIONATE (200 MG) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Erythromycin lactobionate
3847-29-8
|
1KG | 98%min | 1000kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-01-05 | Erythromycin lactobionate
3847-29-8
|
$113.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2024-08-12 | ERYTHROMYCIN LACTOBIONATE
3847-29-8
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- Erythromycin lactobionate
3847-29-8
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Erythromycin lactobionate
3847-29-8
- $113.00
- TargetMol Chemicals Inc.
-
- ERYTHROMYCIN LACTOBIONATE
3847-29-8
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
