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PF-03715455

PF-03715455 Structure
PF-03715455 structure
CAS No.
1056164-52-3
Chemical Name:
PF-03715455
Synonyms
PF-03715455;PF03715455,PF 03715455;1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea;Urea, N-[1-(3-chloro-4-hydroxyphenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[[2-[[3-[2-[(2-hydroxyethyl)thio]phenyl]-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio]phenyl]methyl]-
CBNumber:
CB55867276
Molecular Formula:
C35H34ClN7O3S2
Molecular Weight:
700.27
MDL Number:
MFCD27987916
MOL File:
1056164-52-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:05:25
Request For Quotation

PF-03715455 Properties

Melting point 220 °C
Density 1.39±0.1 g/cm3(Predicted)
pka 7.45±0.20(Predicted)
FDA UNII 0TJ631J0KP

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

PF-03715455 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth GSB16452 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyri din-6-yl)thio)benzyl)urea 1056164-52-3 5mg $1261.35 2026-06-04 Buy
Biosynth GSB16452 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyri din-6-yl)thio)benzyl)urea 1056164-52-3 10mg $1754.9 2026-06-04 Buy
Biosynth GSB16452 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyri din-6-yl)thio)benzyl)urea 1056164-52-3 25mg $3290.5 2026-06-04 Buy
Biosynth GSB16452 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyri din-6-yl)thio)benzyl)urea 1056164-52-3 50mg $5264.5 2026-06-04 Buy
ChemScene CS-0014537 PF-03715455 98.44% 1056164-52-3 1mg $54 2026-06-04 Buy
Product number Packaging Price Buy
GSB16452 5mg $1261.35 Buy
GSB16452 10mg $1754.9 Buy
GSB16452 25mg $3290.5 Buy
GSB16452 50mg $5264.5 Buy
CS-0014537 1mg $54 Buy

PF-03715455 Chemical Properties, Uses, Production

Uses

PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)[1][2].

in vivo

PF-03715455 treatment shows that the Vss and T1/2 are 0.19 L/kg, 1 hour, respectively[2].

Animal Model:Male CD Sprague Dawley rats (300-450 g)[2]
Dosage:1 mg/kg
Administration:I.v. (Pharmacokinetic Analysis)
Result:The Vss, and T1/2 were 0.19 L/kg, 1 hour, respectively.

IC 50

p38α: 0.88 nM (IC50); p38β: 23 nM (IC50)

References

[1] Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. DOI:10.1517/13543784.2015.1006358
[2] Millan DS, et al. Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem. 2011 Nov 24;54(22):7797-814. DOI:10.1021/jm200677b

PF-03715455 synthesis

1344738-18-6
1056164-52-3
Synthesis of PF-03715455 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

PF-03715455 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-03715455 Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 618 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd dexuanyiyao@126.com dexuanyiyao@126.com China 9470 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 11975 58
Supplier Advantage
BOC Sciences 65
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd 58
cjbscvictory 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Latest Price from PF-03715455 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-03715455 pictures 2026-08-25 PF-03715455
1056164-52-3
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • PF-03715455 pictures
  • PF-03715455
    1056164-52-3
  • $2.00-5.00
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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PF-03715455 Urea, N-[1-(3-chloro-4-hydroxyphenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[[2-[[3-[2-[(2-hydroxyethyl)thio]phenyl]-1,2,4-triazolo[4,3-a]pyridin-6-yl]thio]phenyl]methyl]- PF03715455,PF 03715455 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea 1056164-52-3 C35H34ClN7O3S2