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tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Structure
tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate structure
CAS No.
350684-49-0
Chemical Name:
tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate
Synonyms
tert-Butyl 4-(4-aminobenzoyl);4-(4-Aminobenzoyl)-1-Boc-piperazine;(4-Aminophenyl)(4-Boc-1-piperazinyl)methanone;tert-Butyl 4-(4-aMinobenzoyl)piperazine-1-carboxylate;tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazine;2-[3-Bromo-2-oxo-5-(trifluoromethyl)-1-pyridyl]acetamide;2-[3-Chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide;tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate;1-Piperazinecarboxylic acid, 4-(4-aMinobenzoyl)-, 1,1-diMethylethyl ester
CBNumber:
CB5732076
Molecular Formula:
C16H23N3O3
Molecular Weight:
305.37
MDL Number:
MFCD06659531
MOL File:
350684-49-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:40
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tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Properties

Melting point 159-160
Boiling point 488.1±40.0 °C(Predicted)
Density 1+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 3.50±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Warning
Hazard statements  H228
Precautionary statements  P403-P501c
HazardClass  IRRITANT
HS Code  2933998090

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR9915 tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 95% 350684-49-0 50mg $45 2026-06-04 Buy
Apolloscientific OR9915 tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 95% 350684-49-0 100mg $63 2026-06-04 Buy
Apolloscientific OR9915 tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 95% 350684-49-0 250mg $89 2026-06-04 Buy
Apolloscientific OR9915 tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 95% 350684-49-0 500mg $156 2026-06-04 Buy
Apolloscientific OR9915 tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate 95% 350684-49-0 1g $199 2026-06-04 Buy
Product number Packaging Price Buy
OR9915 50mg $45 Buy
OR9915 100mg $63 Buy
OR9915 250mg $89 Buy
OR9915 500mg $156 Buy
OR9915 1g $199 Buy

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Chemical Properties,Uses,Production

Synthesis

TERT-BUTYL 4-(4-NITROBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

509073-62-5

TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

350684-49-0

General procedure for the synthesis of tert-butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate from tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate: a mixture of tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate (20 g, 60 mmol) with 10% Pd/C (4 g) in methanol (600 mL) was subjected to hydrogen (1 atm) atmosphere and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 18 g of tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate as a white solid in 100% yield.

References

[1] Patent: WO2013/177536, 2013, A2. Location in patent: Paragraph 0260
[2] Patent: CN102464631, 2016, B. Location in patent: Paragraph 0094-0096
[3] Patent: WO2018/98275, 2018, A1. Location in patent: Page/Page column 126
[4] Patent: WO2018/98288, 2018, A1. Location in patent: Page/Page column 154; 155
[5] Patent: WO2008/139161, 2008, A1. Location in patent: Page/Page column 161-162

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate synthesis

509073-62-5
350684-49-0
Synthesis of tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate from tert-Butyl 4-(4-nitrobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Preparation Products And Raw materials

Raw materials

tert-Butyl 4-(4-nitrobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate 4-Aminobenzoic acid 1-BOC-Piperazine Activated carbon Palladium
Methanol Hydrogen

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Preparation Products

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Suppliers

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3989 55
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3543 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
JIANGYIN CANAL PHARMTECH CO.,LIMITED. +86-18921203887 sales@canalpharm.net China 288 58
NINGBO INNO PHARMCHEM CO.,LTD. 86-574-27787657 info@dearchem.com China 4607 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
parabiochem 025-83453382-8005 sale@parabiochem.com China 9577 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Wuhan TCASChem Technology Co., Ltd. 55
Wuhan Kaymke Chemical Co., Ltd., 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
JIANGYIN CANAL PHARMTECH CO.,LIMITED. 58
NINGBO INNO PHARMCHEM CO.,LTD. 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
parabiochem 55
Amadis Chemical Company Limited 58

View Lastest Price from tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate pictures 2026-06-08 tert-Butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate
350684-49-0
 1kg 99% 1 Jinan Ruitong Biotech Co., Ltd.

tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate Spectrum

TERT-BUTYL 4-(4-AMINOBENZOYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE(350684-49-0)1HNMR

350684-49-0(tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate)Related Search:

tert-Butyl 4-(4-nitrobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 1-(4-Aminobenzoyl)-4-methylpiperazine (4-Aminophenyl)(piperazin-1-yl)methanone
AWCWKIIMNWGBRM-UHFFFAOYSA-N

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tert-Butyl 4-(4-aMinobenzoyl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(4-aMinobenzoyl)-, 1,1-diMethylethyl ester 2-[3-Chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]acetamide tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazine tert-Butyl 4-(4-aminobenzoyl) 2-[3-Bromo-2-oxo-5-(trifluoromethyl)-1-pyridyl]acetamide 4-(4-Aminobenzoyl)-1-Boc-piperazine (4-Aminophenyl)(4-Boc-1-piperazinyl)methanone tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate 350684-49-0